Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-YefM
Location 20361..20911 Replicon chromosome
Accession NZ_CP046849
Organism Vibrio cincinnatiensis strain F8054

Toxin (Protein)


Gene name parE Uniprot ID A0A1T4SPA2
Locus tag GPX94_RS13040 Protein ID WP_039428516.1
Coordinates 20361..20660 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A099LYH9
Locus tag GPX94_RS13045 Protein ID WP_039428513.1
Coordinates 20669..20911 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPX94_RS13015 16837..17058 + 222 Protein_27 transposase -
GPX94_RS13020 17142..17993 + 852 WP_158147655.1 IS3 family transposase -
GPX94_RS13025 18044..18502 + 459 WP_065818886.1 hypothetical protein -
GPX94_RS13030 19153..19725 + 573 WP_000417044.1 hypothetical protein -
GPX94_RS13035 20190..20315 + 126 WP_080289624.1 DUF3265 domain-containing protein -
GPX94_RS13040 20361..20660 - 300 WP_039428516.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GPX94_RS13045 20669..20911 - 243 WP_039428513.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GPX94_RS13050 21022..21117 + 96 Protein_34 DUF3265 domain-containing protein -
GPX94_RS13055 21627..22100 + 474 WP_154116328.1 hypothetical protein -
GPX94_RS13060 22115..22207 + 93 WP_081302018.1 DUF3265 domain-containing protein -
GPX94_RS13065 22342..23466 - 1125 WP_154116312.1 ISAs1 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - cqsA / katB 1..1034285 1034284


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-56)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11622.26 Da        Isoelectric Point: 9.6429

>T145096 WP_039428516.1 NZ_CP046849:c20660-20361 [Vibrio cincinnatiensis]
MHNKQYKLSSLAQTHLRKVKNYTINNFSELQWQRYKETLLSGFQMLADNPDLGRSCHEIYSNGFYFPIGKHTAYFTKEEN
FILIVAVLGQSQLPQNHLK

Download         Length: 300 bp

>T145096 NZ_CP062260:6873266-6873616 [Paenibacillus sp. JNUCC-32]
GTGATCGTTAAACGGGGCGACGTATTTTTTGCGGATTTATCACCTGTTGTCGGTTCTGAGCAAGGCGGCGTGAGACCGGT
CCTTGTCATTCAGAACGATATCGGCAACCGGTTTAGTCCGACTGTGATTGTTGCAGCCATTACGGCACAGATTCAAAAAG
CCAAGCTGCCGACTCACGTCGAAATCGACGCGGCGTCGCATGGATTTGACCGGGATTCCGTCATTTTGCTAGAGCAGATC
CGGACGATTGATAAGCAGCGGCTAACCGACAAAATCACCCATCTTGATGATGAAATGATGAGCAAGGTGGATGATTCCCT
GCAAATAAGTCTGGGCTTGATTGATTTTTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9164.51 Da        Isoelectric Point: 5.6772

>AT145096 WP_039428513.1 NZ_CP046849:c20911-20669 [Vibrio cincinnatiensis]
MYTLTANDAKRNFGELLLNAQRQPIKISKNSKDAVVVMSIHDYEELEMMKTEYLKHCFNVAKDDLAKGNVVDGKDFLNEL

Download         Length: 243 bp

>AT145096 NZ_CP062260:6872990-6873262 [Paenibacillus sp. JNUCC-32]
ATGCAGAACACCAAACGAATCATGATCAGTTTACCGGATCATCTTTTGCAGGAAGTGGACGGGATCGCTCAGCTGGAAAA
TTCCAACCGCAGTGAGCTTATTAGGCAGGCCATGAAGTTGTACCTGAATGAACGGAAGAAACGTTACATTCGTGAATCCA
TGCAGCGGGGTTATATGGAAATGGCCAAAATTAACCTGACCATGGCTTCTGAGGCGTTTCACGCGGAGGAAGATGCAGAC
AACACTCTAGACCGCTTAGTAAGCGGGGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1T4SPA2

Antitoxin

Source ID Structure
AlphaFold DB A0A099LYH9

References