Detailed information of TA system TA145095

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-Phd
• Location: 548799..549377
• Replicon: chromosome
• Accession: NZ_CP046847
• Organism: Vibrio mimicus strain F9458

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: GPY12_RS17545
• Protein ID: WP_059261326.1
• Coordinates: 548799..549116 (-)
• Length: 106 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: GPY12_RS17550
• Protein ID: WP_148546882.1
• Coordinates: 549135..549377 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GPY12_RS17490	544088..544585	+	498	WP_148546875.1	GNAT family N-acetyltransferase	-
GPY12_RS20850	545458..545628	+	171	Protein_564	DUF645 family protein	-
GPY12_RS17510	545839..546288	+	450	WP_148546940.1	GNAT family N-acetyltransferase	-
GPY12_RS17515	546342..546461	+	120	WP_148546878.1	acetyltransferase	-
GPY12_RS17520	546430..546759	+	330	WP_148546879.1	hypothetical protein	-
GPY12_RS17525	546914..547291	+	378	WP_148546880.1	hypothetical protein	-
GPY12_RS17530	547270..547398	+	129	Protein_569	DUF3265 domain-containing protein	-
GPY12_RS17535	547589..547765	+	177	WP_187377634.1	DUF645 family protein	-
GPY12_RS17540	548426..548643	+	218	Protein_571	DUF645 family protein	-
GPY12_RS17545	548799..549116	-	318	WP_059261326.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GPY12_RS17550	549135..549377	-	243	WP_148546882.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
GPY12_RS17555	549650..549870	+	221	Protein_574	DUF1289 domain-containing protein	-
GPY12_RS17575	550358..551317	-	960	WP_148546885.1	IS30 family transposase	-
GPY12_RS17585	551565..552176	+	612	Protein_576	M23 family metallopeptidase	-
GPY12_RS17590	552294..552731	+	438	WP_148546886.1	IS200/IS605 family transposase	-
GPY12_RS17595	552795..553702	-	908	Protein_578	LysR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	552294..552731	437
	-	inside	Integron	-	-	414046..552251	138205

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-93)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-69)

Sequences

Toxin

Protein

• Length: 106 a.a.
• Molecular weight: 12194.02 Da
• Isoelectric Point: 9.5547

>T145095 WP_059261326.1 NZ_CP046847:c549116-548799 [Vibrio mimicus]
MQNKQYKLSQLAQEHLLKIRNYTIENFAQAQWLKYKSTLLSGFQTLADNPELGKSCEDIYKNGFYFPVGKHMAYYTKEAD
FILIVAVLGQSQLPQKHLTQSRFVS

Nucleotide

• Length: 318 bp

>T145095 NZ_CP062257:c18557-18225 [Xanthomonas sp. WG16]
ATGGATCGCGGCGATGTCTATTTGGTTTCGCTCGATCCCACGTCCGGCCATGAACAACAGGGCACGCGCCCGGTGCTGAT
TGTGTCGCCAAGCGCGTTCAACCGCCTGACGAAAACACCGGTCGTGCTGCCGATCACCAGTGGGGGTAACTTCGCCCGCA
CGGCAGGCTTTACCGTGTCGCTCATGGGTGCGGGTACCAACACAACTGGCGTAGTTCGCTGCGATCAGCCCCGCGCTCTC
GATCTAGCCTCGCGGCGCGCGCGCAAGCTGGAAACCGTGCCGTCCCCGATCATGGATGAGGTATTAGCGAAGCTGAGCGC
GATCCTTGAGTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9028.34 Da
• Isoelectric Point: 5.0491

>AT145095 WP_148546882.1 NZ_CP046847:c549377-549135 [Vibrio mimicus]
MYTLTANDAKRNFGELLLSAQREPIIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDNGKTVDGATFLNTL

Nucleotide

• Length: 243 bp

>AT145095 NZ_CP062257:c18814-18557 [Xanthomonas sp. WG16]
ATGCATACGACCAATCTGCGTAAGGTCGGTGGCTCGATCATGTTGGCTGTCCCGCCCGCCATTCTGGATATGCTGCGTCT
GCGTGCCGGCGCTACCGTTGGCTTGGCCGTCGATCATGGTCGCCTGGTGATCGAACCCACGCTGCGTCCGTACTACAGCC
TGGATGAGCTGCTGGCCCAATGCGACGCATCCGCCGAACTCTCCACCGAAGATCGGGAATGGCTCGACGCCAAGCCTGTT
GGCAGCGAGCTGCTGTGA