Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | phd-doc/Doc(toxin) |
| Location | 493533..494104 | Replicon | chromosome |
| Accession | NZ_CP046847 | ||
| Organism | Vibrio mimicus strain F9458 | ||
Toxin (Protein)
| Gene name | doc | Uniprot ID | Q9KMA2 |
| Locus tag | GPY12_RS17015 | Protein ID | WP_000351248.1 |
| Coordinates | 493703..494104 (+) | Length | 134 a.a. |
Antitoxin (Protein)
| Gene name | phd | Uniprot ID | Q8GNG3 |
| Locus tag | GPY12_RS17010 | Protein ID | WP_001080654.1 |
| Coordinates | 493533..493703 (+) | Length | 57 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GPY12_RS16970 | 488754..489203 | + | 450 | WP_025555177.1 | GNAT family N-acetyltransferase | - |
| GPY12_RS16975 | 489244..489321 | + | 78 | WP_072606006.1 | hypothetical protein | - |
| GPY12_RS16980 | 489367..490116 | - | 750 | WP_158139781.1 | hypothetical protein | - |
| GPY12_RS16985 | 490151..490252 | + | 102 | WP_113606188.1 | DUF3265 domain-containing protein | - |
| GPY12_RS16990 | 490325..490816 | + | 492 | WP_000735771.1 | DUF2059 domain-containing protein | - |
| GPY12_RS16995 | 491623..492444 | + | 822 | WP_148547066.1 | hypothetical protein | - |
| GPY12_RS17000 | 492428..492556 | + | 129 | WP_148547065.1 | DUF3265 domain-containing protein | - |
| GPY12_RS17005 | 492612..493352 | + | 741 | WP_187377648.1 | PhzF family phenazine biosynthesis protein | - |
| GPY12_RS17010 | 493533..493703 | + | 171 | WP_001080654.1 | hypothetical protein | Antitoxin |
| GPY12_RS17015 | 493703..494104 | + | 402 | WP_000351248.1 | type II toxin-antitoxin system death-on-curing family toxin | Toxin |
| GPY12_RS17025 | 494249..494623 | + | 375 | WP_025523884.1 | hypothetical protein | - |
| GPY12_RS17030 | 494649..494741 | + | 93 | WP_078555132.1 | DUF3265 domain-containing protein | - |
| GPY12_RS17035 | 494751..495228 | + | 478 | Protein_475 | dual specificity protein phosphatase family protein | - |
| GPY12_RS20830 | 495285..495365 | + | 81 | Protein_476 | acetyltransferase | - |
| GPY12_RS17040 | 495402..495638 | - | 237 | WP_148547056.1 | RNA-binding protein | - |
| GPY12_RS17045 | 495894..496334 | + | 441 | WP_038964936.1 | hypothetical protein | - |
| GPY12_RS17050 | 496471..496842 | + | 372 | WP_158139783.1 | hypothetical protein | - |
| GPY12_RS17055 | 496980..497384 | + | 405 | WP_148547057.1 | DUF2007 domain-containing protein | - |
| GPY12_RS17060 | 497691..497873 | + | 183 | WP_000923321.1 | DUF645 family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integron | - | - | 414046..552251 | 138205 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 134 a.a. Molecular weight: 14608.71 Da Isoelectric Point: 4.0128
>T145094 WP_000351248.1 NZ_CP046847:493703-494104 [Vibrio mimicus]
MDIICFPFERVIEINAFILKTEPGMKGAVDIPKLQGALGRIDNAIVYEGLDDVFEIAAKYTACIAVSHALPDANKRTGLA
VALEYLSLNDFELTQENDLLADAVRDLVIGIINETDFADILYAQYAKEQNSAL
MDIICFPFERVIEINAFILKTEPGMKGAVDIPKLQGALGRIDNAIVYEGLDDVFEIAAKYTACIAVSHALPDANKRTGLA
VALEYLSLNDFELTQENDLLADAVRDLVIGIINETDFADILYAQYAKEQNSAL
Download Length: 402 bp
>T145094 NZ_CP062256:c52028-51627 [Xanthomonas sp. WG16]
ATGAAGCGGTACATGCTTGATACCAACACCGTGAGCCATCTCGTCAAGAGCCATCCGGCTGTCTCTCGACGGGTCATTGA
AGTGCCTATGACTGCGCTATGTATGTCCGCAATTACCGGTGGGGAGCTGATGTTCGGCTTGGCTAAGGTGCCAGACGCCA
AACGCCTTCAGCAAGCCGTCATGGAACTCCTGCGGCGCGTGGATGTGCTGCCTTGGGATGGCGCGGTAATGGAGCGTTAC
GGAAGCGTAAGAGCGGACCTAGAAAAGCAAGGTAAAGCGCTTGGGTCGCTCGACATGCTTATCGCAGCACATGCACTGGA
AACGGATTCTGTCCTCGTTACCAATGACGCCGCATTTAGTCGTGTTGTTGGTTTGACCGTGGAAGATTGGACACGCAGCT
AA
ATGAAGCGGTACATGCTTGATACCAACACCGTGAGCCATCTCGTCAAGAGCCATCCGGCTGTCTCTCGACGGGTCATTGA
AGTGCCTATGACTGCGCTATGTATGTCCGCAATTACCGGTGGGGAGCTGATGTTCGGCTTGGCTAAGGTGCCAGACGCCA
AACGCCTTCAGCAAGCCGTCATGGAACTCCTGCGGCGCGTGGATGTGCTGCCTTGGGATGGCGCGGTAATGGAGCGTTAC
GGAAGCGTAAGAGCGGACCTAGAAAAGCAAGGTAAAGCGCTTGGGTCGCTCGACATGCTTATCGCAGCACATGCACTGGA
AACGGATTCTGTCCTCGTTACCAATGACGCCGCATTTAGTCGTGTTGTTGGTTTGACCGTGGAAGATTGGACACGCAGCT
AA
Antitoxin
Download Length: 57 a.a. Molecular weight: 6287.35 Da Isoelectric Point: 10.7274
>AT145094 WP_001080654.1 NZ_CP046847:493533-493703 [Vibrio mimicus]
MNRKVEAYGVDAVERPKIKASKKLDLTGDAGRQIVKSETKLALRTHQKTFTKLADM
MNRKVEAYGVDAVERPKIKASKKLDLTGDAGRQIVKSETKLALRTHQKTFTKLADM
Download Length: 171 bp
>AT145094 NZ_CP062256:c52285-52025 [Xanthomonas sp. WG16]
GTGAGCCAAGTTGCCAAGCTGTTCATCAATGGCCGCAGCCAGGCAGTCCGCTTGCCTGCCGCCTATCGCTTTACCGAGAA
AGAGGTTTTCATTCGCCAAGACCCGGAGACCGGTGACGTCATCCTGTCTCGGAAGCCTGCAACGTGGGAGGACTTCTTTA
TCGTACTCAAGAGCGCAGATGTGCCTGCTAATTTTCTAGATGCCGCCGAGCGCAATCAGGGCACGCAGGACCGTGATCCT
TTTGCGGGATGGCGCGAATGA
GTGAGCCAAGTTGCCAAGCTGTTCATCAATGGCCGCAGCCAGGCAGTCCGCTTGCCTGCCGCCTATCGCTTTACCGAGAA
AGAGGTTTTCATTCGCCAAGACCCGGAGACCGGTGACGTCATCCTGTCTCGGAAGCCTGCAACGTGGGAGGACTTCTTTA
TCGTACTCAAGAGCGCAGATGTGCCTGCTAATTTTCTAGATGCCGCCGAGCGCAATCAGGGCACGCAGGACCGTGATCCT
TTTGCGGGATGGCGCGAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0Q0PN34 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1T4SJJ1 |