Detailed information of TA system TA145093

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-phd/ParE(toxin)
• Location: 434851..435321
• Replicon: chromosome
• Accession: NZ_CP046847
• Organism: Vibrio mimicus strain F9458

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: GPY12_RS16440
• Protein ID: WP_000229321.1
• Coordinates: 434851..435153 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: -
• Locus tag: GPY12_RS16445
• Protein ID: WP_158139756.1
• Coordinates: 435229..435321 (+)
• Length: 31 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GPY12_RS16410	430448..431656	+	1209	WP_158139391.1	IS256 family transposase	-
GPY12_RS16415	431720..432175	+	456	WP_158139753.1	hypothetical protein	-
GPY12_RS16420	432316..433092	+	777	WP_158139754.1	choline kinase	-
GPY12_RS16425	433231..433842	+	612	WP_070382666.1	pyridoxamine 5'-phosphate oxidase family protein	-
GPY12_RS16430	433990..434415	+	426	WP_158139755.1	GNAT family N-acetyltransferase	-
GPY12_RS16435	434606..434863	+	258	WP_000861987.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
GPY12_RS16440	434851..435153	+	303	WP_000229321.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GPY12_RS16445	435229..435321	+	93	WP_158139756.1	acetyltransferase	Antitoxin
GPY12_RS16450	435323..435781	+	459	WP_158139757.1	GNAT family N-acetyltransferase	-
GPY12_RS16455	435939..436466	+	528	WP_158139758.1	hypothetical protein	-
GPY12_RS16460	436456..436549	+	94	Protein_371	DUF3265 domain-containing protein	-
GPY12_RS16465	436592..437284	+	693	WP_158139759.1	hypothetical protein	-
GPY12_RS16470	437425..437559	+	135	WP_199250819.1	DUF3709 domain-containing protein	-
GPY12_RS16480	437869..438186	-	318	WP_000077453.1	CcdB family protein	-
GPY12_RS16485	438186..438431	-	246	WP_158139761.1	type II toxin-antitoxin system CcdA family antitoxin	-
GPY12_RS16490	438959..439081	+	123	WP_079858292.1	DUF3265 domain-containing protein	-
GPY12_RS16495	439116..439511	+	396	WP_199250820.1	DUF3465 domain-containing protein	-
GPY12_RS16500	439735..440205	+	471	WP_158139763.1	hypothetical protein	-
GPY12_RS16505	440228..440320	+	93	WP_199250821.1	DUF3265 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	430448..431656	1208
	-	inside	Integron	-	-	414046..552251	138205

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-87)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11771.68 Da
• Isoelectric Point: 5.1972

>T145093 WP_000229321.1 NZ_CP046847:434851-435153 [Vibrio mimicus]
MVEIIWTEPALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVNPCRVFYKYDDAKV
RILFVMRAERDLRRFMLTKQ

Nucleotide

• Length: 303 bp

>T145093 NZ_CP062256:c31719-31393 [Xanthomonas sp. WG16]
ATGATGCGGGGTGACTTTGTGACCATCGCCATGCAAGGCGACTTCGGAAAACCAAGGCCCGCTCTGGTGATCCAGGCCGA
CCAGTTTGACGCACACACCACCGTGACGGTGCTGCCGGTGACAAGCACGCTCGTTGCTGCGCCGCTGCTGCGTATTACCG
TTCATCCAAGTACCGACAATGGTTTGCAGAAGCCGTCTCAGGTGATGGTGGACAAGGCCATGACCGTGAAGCGTGACAAG
GTAGGTCGAGCCTTTGGGCGCGTAGACGCTGATGCGTTGGTGGAAATTGAGCGCTGCCTGGCCGTGTTCTTGGGCATCGC
TAAGTGA

Antitoxin

Protein

• Length: 31 a.a.
• Molecular weight: 3555.30 Da
• Isoelectric Point: 9.7750

>AT145093 WP_158139756.1 NZ_CP046847:435229-435321 [Vibrio mimicus]
VVTVVVFEFSVMRCQPLRRALYAYIKFGVY

Nucleotide

• Length: 93 bp

>AT145093 NZ_CP062256:c31934-31716 [Xanthomonas sp. WG16]
ATGGCACACGTCAATTCACGAGTTCAAAAGCACCGCGACGCCCTGCGCATGGCAGGGCTGCGTCCGGTGCAAATTTGGGT
GCCGGACACACGGCGGCCTGACTTCGCCGAGGAATGCCGCCGTCAGTGTCGTCTTGCTGCACAAGCGGACATGGCGGATA
CCGACATGCAGCGCTTCATGGATGAGGCGCTAGCAGACATGGATGGCTGGACGGAATGA