Detailed information of TA system TA145091

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-Phd
• Location: 110697..111275
• Replicon: chromosome
• Accession: NZ_CP046845
• Organism: Vibrio cholerae C6706

Toxin (Protein)

• Gene name: parE
• Uniprot ID: O68848
• Locus tag: GPY04_RS15040
• Protein ID: WP_001180243.1
• Coordinates: 110958..111275 (+)
• Length: 106 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q7DCR7
• Locus tag: GPY04_RS15035
• Protein ID: WP_000557292.1
• Coordinates: 110697..110939 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GPY04_RS14975	106091..106537	-	447	WP_000006157.1	hypothetical protein	-
GPY04_RS14985	106733..106771	-	39	WP_106019118.1	hypothetical protein	-
GPY04_RS14990	106787..106912	-	126	WP_001900195.1	DUF645 family protein	-
GPY04_RS14995	107305..107577	+	273	WP_000246253.1	DUF1778 domain-containing protein	-
GPY04_RS15000	107574..108071	+	498	WP_000982260.1	GNAT family N-acetyltransferase	-
GPY04_RS15005	108221..108736	-	516	WP_001201509.1	lipocalin family protein	-
GPY04_RS15010	108873..109409	-	537	WP_000469482.1	GNAT family N-acetyltransferase	-
GPY04_RS15020	109667..109948	-	282	WP_001894429.1	DUF1289 domain-containing protein	-
GPY04_RS15025	109897..110010	-	114	WP_001900214.1	hypothetical protein	-
GPY04_RS15030	110067..110453	-	387	WP_001015867.1	NUDIX hydrolase	-
GPY04_RS15035	110697..110939	+	243	WP_000557292.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
GPY04_RS15040	110958..111275	+	318	WP_001180243.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GPY04_RS15050	111429..111767	-	339	WP_000713853.1	hypothetical protein	-
GPY04_RS15055	111925..112629	-	705	WP_000087610.1	HNH endonuclease	-
GPY04_RS15060	112791..113999	-	1209	WP_000272282.1	deoxyguanosinetriphosphate triphosphohydrolase family protein	-
GPY04_RS15065	114161..114838	-	678	WP_000254617.1	HNH endonuclease	-
GPY04_RS15070	115033..115215	-	183	WP_000923153.1	DUF645 family protein	-
GPY04_RS15075	115569..115751	-	183	WP_000923340.1	DUF645 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integron	catB9	hlyA / vgrG-3 / vasL / icmF/vasK / vasJ / vasI / vasH / clpB/vasG / vasF / vasE / vasD / vasC / vasB / vasA / VCA0109 / vipB/mglB / vipA/mglA / vgrG-2 / hcp-2 / hlyA / htpB / ugd / cqsA	113..1070288	1070175

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-93)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-71)

Sequences

Toxin

Protein

• Length: 106 a.a.
• Molecular weight: 12158.97 Da
• Isoelectric Point: 9.7495

>T145091 WP_001180243.1 NZ_CP046845:110958-111275 [Vibrio cholerae C6706]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Nucleotide

• Length: 318 bp

>T145091 NZ_CP062255:c4673345-4673193 [Xanthomonas sp. WG16]
ATGAAGCGACTGCTGACACTGATGGTGCTGGGCCTGTTTTCGGCCGGCGTGATGACGGGCTGCAACACCGTGGCCGGCGC
CGGCAAGGACATGCAGGGTGCGGGCAACAAGGTCGAGAAAACGGCCGAAAAATGCAGCGACGGTAAGTGCTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8961.25 Da
• Isoelectric Point: 5.6630

>AT145091 WP_000557292.1 NZ_CP046845:110697-110939 [Vibrio cholerae C6706]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Nucleotide

• Length: 243 bp

>AT145091 NZ_CP062255:c4673118-4672984 [Xanthomonas sp. WG16]
ATGAAGCGTGCAATTGTGCTGCTGGTGCTGTCGATGTTGTCGGTGGGAATGCTGGCGGGTTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGCAGGGCGCTGGCGAGAAGGTGGAAGACGCAGCGCGTAAGTAA

Structures

Toxin

• AlphaFold DB: A0A0K9UJR8

Antitoxin

• AlphaFold DB: Q7DCR7