Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 107305..108071 Replicon chromosome
Accession NZ_CP046845
Organism Vibrio cholerae C6706

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag GPY04_RS15000 Protein ID WP_000982260.1
Coordinates 107574..108071 (+) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9K2J6
Locus tag GPY04_RS14995 Protein ID WP_000246253.1
Coordinates 107305..107577 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPY04_RS14930 102802..103044 - 243 WP_000107461.1 hypothetical protein -
GPY04_RS14935 103136..103285 - 150 WP_071908333.1 DUF3265 domain-containing protein -
GPY04_RS14940 103258..103509 - 252 WP_001890111.1 TIGR03643 family protein -
GPY04_RS14945 103704..104090 - 387 WP_000703163.1 VOC family protein -
GPY04_RS14950 104080..104181 - 102 WP_001921603.1 hypothetical protein -
GPY04_RS14955 104381..104587 - 207 Protein_185 DUF3709 domain-containing protein -
GPY04_RS14960 104839..105117 - 279 WP_001921601.1 DUF3709 domain-containing protein -
GPY04_RS14965 105403..105681 + 279 WP_001258569.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
GPY04_RS14970 105674..105943 + 270 WP_000277238.1 type II toxin-antitoxin system YafQ family toxin -
GPY04_RS14975 106091..106537 - 447 WP_000006157.1 hypothetical protein -
GPY04_RS14985 106733..106771 - 39 WP_106019118.1 hypothetical protein -
GPY04_RS14990 106787..106912 - 126 WP_001900195.1 DUF645 family protein -
GPY04_RS14995 107305..107577 + 273 WP_000246253.1 DUF1778 domain-containing protein Antitoxin
GPY04_RS15000 107574..108071 + 498 WP_000982260.1 GNAT family N-acetyltransferase Toxin
GPY04_RS15005 108221..108736 - 516 WP_001201509.1 lipocalin family protein -
GPY04_RS15010 108873..109409 - 537 WP_000469482.1 GNAT family N-acetyltransferase -
GPY04_RS15020 109667..109948 - 282 WP_001894429.1 DUF1289 domain-containing protein -
GPY04_RS15025 109897..110010 - 114 WP_001900214.1 hypothetical protein -
GPY04_RS15030 110067..110453 - 387 WP_001015867.1 NUDIX hydrolase -
GPY04_RS15035 110697..110939 + 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
GPY04_RS15040 110958..111275 + 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin -
GPY04_RS15050 111429..111767 - 339 WP_000713853.1 hypothetical protein -
GPY04_RS15055 111925..112629 - 705 WP_000087610.1 HNH endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron catB9 hlyA / vgrG-3 / vasL / icmF/vasK / vasJ / vasI / vasH / clpB/vasG / vasF / vasE / vasD / vasC / vasB / vasA / VCA0109 / vipB/mglB / vipA/mglA / vgrG-2 / hcp-2 / hlyA / htpB / ugd / cqsA 113..1070288 1070175


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T145090 WP_000982260.1 NZ_CP046845:107574-108071 [Vibrio cholerae C6706]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

>T145090 NZ_CP062255:c4673118-4672984 [Xanthomonas sp. WG16]
ATGAAGCGTGCAATTGTGCTGCTGGTGCTGTCGATGTTGTCGGTGGGAATGCTGGCGGGTTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGCAGGGCGCTGGCGAGAAGGTGGAAGACGCAGCGCGTAAGTAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9683.22 Da        Isoelectric Point: 6.2988

>AT145090 WP_000246253.1 NZ_CP046845:107305-107577 [Vibrio cholerae C6706]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp

>AT145090 NZ_CP062255:c4673345-4673193 [Xanthomonas sp. WG16]
ATGAAGCGACTGCTGACACTGATGGTGCTGGGCCTGTTTTCGGCCGGCGTGATGACGGGCTGCAACACCGTGGCCGGCGC
CGGCAAGGACATGCAGGGTGCGGGCAACAAGGTCGAGAAAACGGCCGAAAAATGCAGCGACGGTAAGTGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Q0KGB1

Antitoxin

Source ID Structure
PDB 1Y9B
AlphaFold DB A0A0F2IC79

References