Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/YafQ-RelB |
| Location | 105403..105943 | Replicon | chromosome |
| Accession | NZ_CP046845 | ||
| Organism | Vibrio cholerae C6706 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | A0A151JGK8 |
| Locus tag | GPY04_RS14970 | Protein ID | WP_000277238.1 |
| Coordinates | 105674..105943 (+) | Length | 90 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | Q9KML3 |
| Locus tag | GPY04_RS14965 | Protein ID | WP_001258569.1 |
| Coordinates | 105403..105681 (+) | Length | 93 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GPY04_RS14915 | 100983..101450 | - | 468 | WP_001289288.1 | OsmC family protein | - |
| GPY04_RS19395 | 101662..101700 | - | 39 | WP_082798268.1 | hypothetical protein | - |
| GPY04_RS19400 | 101754..101897 | - | 144 | Protein_178 | DUF645 family protein | - |
| GPY04_RS14925 | 102272..102550 | - | 279 | WP_000280324.1 | DUF3709 domain-containing protein | - |
| GPY04_RS14930 | 102802..103044 | - | 243 | WP_000107461.1 | hypothetical protein | - |
| GPY04_RS14935 | 103136..103285 | - | 150 | WP_071908333.1 | DUF3265 domain-containing protein | - |
| GPY04_RS14940 | 103258..103509 | - | 252 | WP_001890111.1 | TIGR03643 family protein | - |
| GPY04_RS14945 | 103704..104090 | - | 387 | WP_000703163.1 | VOC family protein | - |
| GPY04_RS14950 | 104080..104181 | - | 102 | WP_001921603.1 | hypothetical protein | - |
| GPY04_RS14955 | 104381..104587 | - | 207 | Protein_185 | DUF3709 domain-containing protein | - |
| GPY04_RS14960 | 104839..105117 | - | 279 | WP_001921601.1 | DUF3709 domain-containing protein | - |
| GPY04_RS14965 | 105403..105681 | + | 279 | WP_001258569.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| GPY04_RS14970 | 105674..105943 | + | 270 | WP_000277238.1 | type II toxin-antitoxin system YafQ family toxin | Toxin |
| GPY04_RS14975 | 106091..106537 | - | 447 | WP_000006157.1 | hypothetical protein | - |
| GPY04_RS14985 | 106733..106771 | - | 39 | WP_106019118.1 | hypothetical protein | - |
| GPY04_RS14990 | 106787..106912 | - | 126 | WP_001900195.1 | DUF645 family protein | - |
| GPY04_RS14995 | 107305..107577 | + | 273 | WP_000246253.1 | DUF1778 domain-containing protein | - |
| GPY04_RS15000 | 107574..108071 | + | 498 | WP_000982260.1 | GNAT family N-acetyltransferase | - |
| GPY04_RS15005 | 108221..108736 | - | 516 | WP_001201509.1 | lipocalin family protein | - |
| GPY04_RS15010 | 108873..109409 | - | 537 | WP_000469482.1 | GNAT family N-acetyltransferase | - |
| GPY04_RS15020 | 109667..109948 | - | 282 | WP_001894429.1 | DUF1289 domain-containing protein | - |
| GPY04_RS15025 | 109897..110010 | - | 114 | WP_001900214.1 | hypothetical protein | - |
| GPY04_RS15030 | 110067..110453 | - | 387 | WP_001015867.1 | NUDIX hydrolase | - |
| GPY04_RS15035 | 110697..110939 | + | 243 | WP_000557292.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integron | catB9 | hlyA / vgrG-3 / vasL / icmF/vasK / vasJ / vasI / vasH / clpB/vasG / vasF / vasE / vasD / vasC / vasB / vasA / VCA0109 / vipB/mglB / vipA/mglA / vgrG-2 / hcp-2 / hlyA / htpB / ugd / cqsA | 113..1070288 | 1070175 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 90 a.a. Molecular weight: 10406.11 Da Isoelectric Point: 9.5084
>T145089 WP_000277238.1 NZ_CP046845:105674-105943 [Vibrio cholerae C6706]
MYKLEYSTQFKKDFKKITKMPISDIIEVGNVISKLQRGEKLEPKNVDHPLTGNWVGFRDCHIKPDLVLIYRVFNDQLQLA
RIGSHSDLF
MYKLEYSTQFKKDFKKITKMPISDIIEVGNVISKLQRGEKLEPKNVDHPLTGNWVGFRDCHIKPDLVLIYRVFNDQLQLA
RIGSHSDLF
Download Length: 270 bp
>T145089 NZ_CP062255:c2840700-2840410 [Xanthomonas sp. WG16]
ATGCCACAAGTAATCTTTGCGCCGGCGGCGATCGGGGACATGCAACGGCTGCGCGAATTCCTGAAGCCGAAGAGTCCCGA
TGCCGCGAGGCGGGCCGGTGAAGCGATTAGGCGCGGCGTCCAGGCTCTCGGTGCCCACCCTCGAATGGGGCGGCTCATAG
AAGATCTGCCTGAACAGTATCGGGAGTGGCTTATCGATTTTGGGGATAGTGGCTATGTGGCTCGGTACCGCCACGCTGGC
GATACCGTCACGATTTTGGCCGTGCGACACCAGAAGGAAGCGGGGTACTGA
ATGCCACAAGTAATCTTTGCGCCGGCGGCGATCGGGGACATGCAACGGCTGCGCGAATTCCTGAAGCCGAAGAGTCCCGA
TGCCGCGAGGCGGGCCGGTGAAGCGATTAGGCGCGGCGTCCAGGCTCTCGGTGCCCACCCTCGAATGGGGCGGCTCATAG
AAGATCTGCCTGAACAGTATCGGGAGTGGCTTATCGATTTTGGGGATAGTGGCTATGTGGCTCGGTACCGCCACGCTGGC
GATACCGTCACGATTTTGGCCGTGCGACACCAGAAGGAAGCGGGGTACTGA
Antitoxin
Download Length: 93 a.a. Molecular weight: 10088.58 Da Isoelectric Point: 6.0728
>AT145089 WP_001258569.1 NZ_CP046845:105403-105681 [Vibrio cholerae C6706]
MRTEMLSTRIDHDTKIAFTNVCDEMGLSTSQAIKLFAKAVINHGGIPFELRVPQPNEVTASAIQELVEGKGHKAESVEAM
LNELTEGKVKHV
MRTEMLSTRIDHDTKIAFTNVCDEMGLSTSQAIKLFAKAVINHGGIPFELRVPQPNEVTASAIQELVEGKGHKAESVEAM
LNELTEGKVKHV
Download Length: 279 bp
>AT145089 NZ_CP062255:c2840966-2840688 [Xanthomonas sp. WG16]
ATGGTTACGGCAACTTCCATCAAGCTTGATGATGAATTGAAAGGGCGGGTTCAGCACTTGGCCGAGGCGCGCCGGCGTAC
CCCGCATTGGATCATGCGCGAAGCCATTGAGCAGTACGTCGAGCGCGAGGAAAAGCGTGAGGCGTTGAACCGGGACACGC
TCAAGGCATGGGATGAATTTCAGGCGACGGGCCTGCACGTGACCGCTGAGGAAGTGGACAAGTGGCTCGCGAGCTGGGGA
ACAGACGACGAACTGCCTCCGCCAGAATGCCACAAGTAA
ATGGTTACGGCAACTTCCATCAAGCTTGATGATGAATTGAAAGGGCGGGTTCAGCACTTGGCCGAGGCGCGCCGGCGTAC
CCCGCATTGGATCATGCGCGAAGCCATTGAGCAGTACGTCGAGCGCGAGGAAAAGCGTGAGGCGTTGAACCGGGACACGC
TCAAGGCATGGGATGAATTTCAGGCGACGGGCCTGCACGTGACCGCTGAGGAAGTGGACAAGTGGCTCGCGAGCTGGGGA
ACAGACGACGAACTGCCTCCGCCAGAATGCCACAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A151JGK8 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A151KTP9 |