145088

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /BrnT(toxin)
Location 99509..100007 Replicon chromosome
Accession NZ_CP046845
Organism Vibrio cholerae C6706

Toxin (Protein)


Gene name - Uniprot ID Q9KMK7
Locus tag GPY04_RS14905 Protein ID WP_000589156.1
Coordinates 99741..100007 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9KMK6
Locus tag GPY04_RS14900 Protein ID WP_000643598.1
Coordinates 99509..99754 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPY04_RS14865 94590..94976 - 387 WP_000703163.1 VOC family protein -
GPY04_RS14870 95133..95639 - 507 WP_000393074.1 hypothetical protein -
GPY04_RS14875 95907..96140 - 234 WP_001890112.1 DUF3709 domain-containing protein -
GPY04_RS14880 96413..96772 - 360 WP_001071541.1 VOC family protein -
GPY04_RS14885 96925..97929 - 1005 WP_000964920.1 LD-carboxypeptidase -
GPY04_RS14890 98145..98327 - 183 WP_000923182.1 DUF645 family protein -
GPY04_RS19390 98388..98516 - 129 WP_071908338.1 general secretion pathway protein GspI -
GPY04_RS14895 98619..99413 - 795 WP_001911581.1 hypothetical protein -
GPY04_RS14900 99509..99754 - 246 WP_000643598.1 hypothetical protein Antitoxin
GPY04_RS14905 99741..100007 - 267 WP_000589156.1 BrnT family toxin Toxin
GPY04_RS14910 100192..100855 - 664 Protein_175 hypothetical protein -
GPY04_RS14915 100983..101450 - 468 WP_001289288.1 OsmC family protein -
GPY04_RS19395 101662..101700 - 39 WP_082798268.1 hypothetical protein -
GPY04_RS19400 101754..101897 - 144 Protein_178 DUF645 family protein -
GPY04_RS14925 102272..102550 - 279 WP_000280324.1 DUF3709 domain-containing protein -
GPY04_RS14930 102802..103044 - 243 WP_000107461.1 hypothetical protein -
GPY04_RS14935 103136..103285 - 150 WP_071908333.1 DUF3265 domain-containing protein -
GPY04_RS14940 103258..103509 - 252 WP_001890111.1 TIGR03643 family protein -
GPY04_RS14945 103704..104090 - 387 WP_000703163.1 VOC family protein -
GPY04_RS14950 104080..104181 - 102 WP_001921603.1 hypothetical protein -
GPY04_RS14955 104381..104587 - 207 Protein_185 DUF3709 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron catB9 hlyA / vgrG-3 / vasL / icmF/vasK / vasJ / vasI / vasH / clpB/vasG / vasF / vasE / vasD / vasC / vasB / vasA / VCA0109 / vipB/mglB / vipA/mglA / vgrG-2 / hcp-2 / hlyA / htpB / ugd / cqsA 113..1070288 1070175


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(6-81)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10092.34 Da        Isoelectric Point: 7.3171

>T145088 WP_000589156.1 NZ_CP046845:c100007-99741 [Vibrio cholerae C6706]
MIKFEFDENKSRSNLEKHGIDFHTAQGLWNDSDLIEIPANTSDEPRYLVVGLLNGKHWSGVITYRGTNIRIISVRRSRKA
EVSLYESA

Download         Length: 267 bp

>T145088 NZ_CP062255:c2573655-2573242 [Xanthomonas sp. WG16]
ATGGCCGCGGGTAAGGGCAAAGTGTTTCTCGACAGCAACGTGGTGCTCTACCTGCTGTCGGAGGATGCGGTGAAGGCGGA
CGGCGCGGAGGCATTGCTGCAGCGCAGGCCCGTCATCAGTGTGCAGGTGCTCAATGAAGTGACCCACGTCTGCGTTCGCA
AGCTCAAGATGGGCTGGGACGAAGTCGGGCAGTTCCTTGCGTTGGTGCGATCGTTCTGCAAGATAGTGCCTCTGACGGTC
GATGTTCACGACCGTGCGCGCCAGCTGGCGGAGCGGCACCAATTGTCGTTCTACGACGCGTGCATCGTGGCGGCGGCCGC
CATCGAAGGGTGCCAGACCCTCTACTCCGAAGACATGCACCACGGCCTCATCATCGAAGAGAGCCTGTCGATTCGGAACC
CGTTCAACGTCTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9478.77 Da        Isoelectric Point: 6.4832

>AT145088 WP_000643598.1 NZ_CP046845:c99754-99509 [Vibrio cholerae C6706]
MKAHEFDAKFESDDDDIVMDLDLSQAKRPMHKQKRVNVDFPAWMLESLDREASRIGVTRQSIIKIWLAERLESVSHHSSV
R

Download         Length: 246 bp

>AT145088 NZ_CP062255:c2573875-2573642 [Xanthomonas sp. WG16]
ATGCAAGTCGCGAAGTGGGGTAACAGCCTGGCGGTGCGCCTGCCGTCCAGTCTGGTGGAAGCGCTGGAACTGCGCGAGGG
CGACGACATCGAGATCGTCGTCGATGATCCGCGATTGTTCGCGGTGCGCAAGAAGCCGGGTCCGGAGGCCATGTTGGAGC
GGCTGCGTGCCTTCCGGGGCAAGTTGCCCGCAGATTTCAAGTTCAACCGGGACGAGGCCAATGGCCGCGGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A271VMP7

Antitoxin

Source ID Structure
AlphaFold DB A0A271VME2

References