Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/RelE-RelB |
| Location | 90618..91177 | Replicon | chromosome |
| Accession | NZ_CP046845 | ||
| Organism | Vibrio cholerae C6706 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | Q9K2M8 |
| Locus tag | GPY04_RS14825 | Protein ID | WP_000578476.1 |
| Coordinates | 90899..91177 (+) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | Q9L991 |
| Locus tag | GPY04_RS14820 | Protein ID | WP_000381183.1 |
| Coordinates | 90618..90902 (+) | Length | 95 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GPY04_RS14780 | 86284..86394 | - | 111 | WP_079857360.1 | DUF3265 domain-containing protein | - |
| GPY04_RS14785 | 86404..87102 | - | 699 | WP_001890502.1 | hypothetical protein | - |
| GPY04_RS14790 | 87225..87851 | - | 627 | WP_000365424.1 | LysE family translocator | - |
| GPY04_RS14795 | 87893..87985 | - | 93 | WP_014378730.1 | DUF3265 domain-containing protein | - |
| GPY04_RS14800 | 88000..88473 | - | 474 | WP_001161076.1 | GrpB family protein | - |
| GPY04_RS14805 | 88673..88855 | - | 183 | WP_000923182.1 | DUF645 family protein | - |
| GPY04_RS14810 | 89247..89843 | - | 597 | WP_000255434.1 | hypothetical protein | - |
| GPY04_RS14815 | 89908..90423 | - | 516 | WP_001201520.1 | lipocalin family protein | - |
| GPY04_RS14820 | 90618..90902 | + | 285 | WP_000381183.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| GPY04_RS14825 | 90899..91177 | + | 279 | WP_000578476.1 | type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family | Toxin |
| GPY04_RS14835 | 91328..91741 | - | 414 | WP_000049420.1 | VOC family protein | - |
| GPY04_RS14840 | 91929..92408 | - | 480 | WP_000009888.1 | lecithin retinol acyltransferase family protein | - |
| GPY04_RS14845 | 92621..93244 | - | 624 | WP_000247070.1 | DUF1349 domain-containing protein | - |
| GPY04_RS14850 | 93450..93875 | - | 426 | WP_000415750.1 | hypothetical protein | - |
| GPY04_RS14855 | 94022..94171 | - | 150 | WP_071908333.1 | DUF3265 domain-containing protein | - |
| GPY04_RS14860 | 94144..94395 | - | 252 | WP_001890111.1 | TIGR03643 family protein | - |
| GPY04_RS14865 | 94590..94976 | - | 387 | WP_000703163.1 | VOC family protein | - |
| GPY04_RS14870 | 95133..95639 | - | 507 | WP_000393074.1 | hypothetical protein | - |
| GPY04_RS14875 | 95907..96140 | - | 234 | WP_001890112.1 | DUF3709 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integron | catB9 | hlyA / vgrG-3 / vasL / icmF/vasK / vasJ / vasI / vasH / clpB/vasG / vasF / vasE / vasD / vasC / vasB / vasA / VCA0109 / vipB/mglB / vipA/mglA / vgrG-2 / hcp-2 / hlyA / htpB / ugd / cqsA | 113..1070288 | 1070175 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10819.59 Da Isoelectric Point: 5.1651
>T145087 WP_000578476.1 NZ_CP046845:90899-91177 [Vibrio cholerae C6706]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND
Download Length: 279 bp
>T145087 NZ_CP062255:99706-100005 [Xanthomonas sp. WG16]
ATGGCTGAAATAATCTGGTCGGTGCCGGCATTGGCTGATCTGGACGCAATTGCCGACTACATCGCAATCGATAACGCACC
CGCTGCAGCGGCGCTGGTGAAACGGGTGTTCGGGCACGTTGAGCAATTGATCGAACACCCGGACAGCGGAAGCCGACCAC
AGGAACTCAAGCGCTCGCGCTATCGCCAGATTGTCGAACCACCTTGCCGCGTGTTCTACCGCGTGGATGGGCAGCGCATC
GTGGTGGTGCACGTCATGCGGTCGGAGCGCGCGCTTCGCGGGAACCGTCTTTCACGCTAA
ATGGCTGAAATAATCTGGTCGGTGCCGGCATTGGCTGATCTGGACGCAATTGCCGACTACATCGCAATCGATAACGCACC
CGCTGCAGCGGCGCTGGTGAAACGGGTGTTCGGGCACGTTGAGCAATTGATCGAACACCCGGACAGCGGAAGCCGACCAC
AGGAACTCAAGCGCTCGCGCTATCGCCAGATTGTCGAACCACCTTGCCGCGTGTTCTACCGCGTGGATGGGCAGCGCATC
GTGGTGGTGCACGTCATGCGGTCGGAGCGCGCGCTTCGCGGGAACCGTCTTTCACGCTAA
Antitoxin
Download Length: 95 a.a. Molecular weight: 10901.25 Da Isoelectric Point: 8.0775
>AT145087 WP_000381183.1 NZ_CP046845:90618-90902 [Vibrio cholerae C6706]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA
Download Length: 285 bp
>AT145087 NZ_CP062255:99461-99718 [Xanthomonas sp. WG16]
ATGCGCACCGAACTTGTCACCACGCTCAAGCGTCAGGCGACCGAACTCCTTGCAGCTGCAGAGCGCGACAAGGAGCCAAT
CCTGATCACACAGCACGGTTTACCCAGTGCCTATCTGGTGGATGTTGCCAGCTATGAGCGCATGCAGCAGCGCATTGCGC
TCCTCGAAGGAATCGCCCGTGGAGAAATGGCAGTCGCGGAAGGCCGTACGCTGAGCCATGAACAGGCACGGCACCGCATG
GCGCGATGGCTGAAATAA
ATGCGCACCGAACTTGTCACCACGCTCAAGCGTCAGGCGACCGAACTCCTTGCAGCTGCAGAGCGCGACAAGGAGCCAAT
CCTGATCACACAGCACGGTTTACCCAGTGCCTATCTGGTGGATGTTGCCAGCTATGAGCGCATGCAGCAGCGCATTGCGC
TCCTCGAAGGAATCGCCCGTGGAGAAATGGCAGTCGCGGAAGGCCGTACGCTGAGCCATGAACAGGCACGGCACCGCATG
GCGCGATGGCTGAAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | Q9K2M8 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A067BL33 |