Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-RHH |
| Location | 84252..84790 | Replicon | chromosome |
| Accession | NZ_CP046845 | ||
| Organism | Vibrio cholerae C6706 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | Q9KMJ0 |
| Locus tag | GPY04_RS14760 | Protein ID | WP_000802136.1 |
| Coordinates | 84491..84790 (+) | Length | 100 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | P58093 |
| Locus tag | GPY04_RS14755 | Protein ID | WP_001107719.1 |
| Coordinates | 84252..84494 (+) | Length | 81 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GPY04_RS14710 | 79668..79808 | - | 141 | WP_001883049.1 | DUF3265 domain-containing protein | - |
| GPY04_RS14715 | 79774..80709 | - | 936 | WP_000051985.1 | restriction endonuclease | - |
| GPY04_RS14720 | 80990..81589 | - | 600 | WP_000429495.1 | hypothetical protein | - |
| GPY04_RS14725 | 81744..82010 | - | 267 | WP_000937852.1 | hypothetical protein | - |
| GPY04_RS14730 | 82224..82907 | - | 684 | WP_000877436.1 | hypothetical protein | - |
| GPY04_RS14740 | 83331..83423 | - | 93 | WP_014164112.1 | DUF3265 domain-containing protein | - |
| GPY04_RS14745 | 83445..84023 | - | 579 | WP_000110120.1 | hypothetical protein | - |
| GPY04_RS14755 | 84252..84494 | + | 243 | WP_001107719.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
| GPY04_RS14760 | 84491..84790 | + | 300 | WP_000802136.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| GPY04_RS14765 | 84918..85313 | - | 396 | WP_000870857.1 | DUF3465 domain-containing protein | - |
| GPY04_RS14770 | 85527..85706 | - | 180 | WP_001883058.1 | DUF645 family protein | - |
| GPY04_RS14780 | 86284..86394 | - | 111 | WP_079857360.1 | DUF3265 domain-containing protein | - |
| GPY04_RS14785 | 86404..87102 | - | 699 | WP_001890502.1 | hypothetical protein | - |
| GPY04_RS14790 | 87225..87851 | - | 627 | WP_000365424.1 | LysE family translocator | - |
| GPY04_RS14795 | 87893..87985 | - | 93 | WP_014378730.1 | DUF3265 domain-containing protein | - |
| GPY04_RS14800 | 88000..88473 | - | 474 | WP_001161076.1 | GrpB family protein | - |
| GPY04_RS14805 | 88673..88855 | - | 183 | WP_000923182.1 | DUF645 family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integron | catB9 | hlyA / vgrG-3 / vasL / icmF/vasK / vasJ / vasI / vasH / clpB/vasG / vasF / vasE / vasD / vasC / vasB / vasA / VCA0109 / vipB/mglB / vipA/mglA / vgrG-2 / hcp-2 / hlyA / htpB / ugd / cqsA | 113..1070288 | 1070175 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 100 a.a. Molecular weight: 11589.29 Da Isoelectric Point: 9.9232
>T145086 WP_000802136.1 NZ_CP046845:84491-84790 [Vibrio cholerae C6706]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA
Download Length: 300 bp
>T145086 NZ_CP062254:c3716615-3716295 [Pectobacterium parmentieri]
ATGCAAACCATACCTGCAATCCCGTCACGGGAGGATAACCCCTGTCCGTCACCCATAGCCGCCTGGCAGCAACTGCTGAC
CTACCTGCTGGAAAAGCACTACGGCCTGACGCTGAACGACACGCCGTTCTGTGAGGAAAACGTGATTCAGGAACATATCG
ATGCTGGCATCACGTTGGTCAATGCCGTGAATTTTCTGGTGGAAAAATACGAACTGGTGCGTATCGACCGCGACGGTTTT
AACTGGCAGGAGCAATCACCGTTTCTTACCGCTGTTGATATTCTCCGTGCCAGACGTGCTACCGGCTTGCTCAAAGCATA
A
ATGCAAACCATACCTGCAATCCCGTCACGGGAGGATAACCCCTGTCCGTCACCCATAGCCGCCTGGCAGCAACTGCTGAC
CTACCTGCTGGAAAAGCACTACGGCCTGACGCTGAACGACACGCCGTTCTGTGAGGAAAACGTGATTCAGGAACATATCG
ATGCTGGCATCACGTTGGTCAATGCCGTGAATTTTCTGGTGGAAAAATACGAACTGGTGCGTATCGACCGCGACGGTTTT
AACTGGCAGGAGCAATCACCGTTTCTTACCGCTGTTGATATTCTCCGTGCCAGACGTGCTACCGGCTTGCTCAAAGCATA
A
Antitoxin
Download Length: 81 a.a. Molecular weight: 8964.84 Da Isoelectric Point: 4.1677
>AT145086 WP_001107719.1 NZ_CP046845:84252-84494 [Vibrio cholerae C6706]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR
Download Length: 243 bp
>AT145086 NZ_CP062254:c3717020-3716685 [Pectobacterium parmentieri]
ATGCCATCGTCTGATACCCCTGAATGGGGACTAAAATGTGCCGTCACTCCGCGATTCGGAGCCAGATTGGTGCAGGAAGG
TCACCGTCTGCACTATCTGGCAGACCGTGCCAGCATTGTCGGTACGTTTAGCAAAACAGAAGCCCAAAGTCTGGAACGTT
GCTTCCCTGAGCTAATTAAGCTGTTGGAACAGAAGCTACGCATGGGGGAACTGAATCCCCGTCAGCAGAACTGCGTCACG
CTGCATTGCAACGAATGGATCTGTGAAGCCGATACGCTGGGCAGTGTTGGCTACGTGTATATTGTTATCTATCCCTCTTC
TGCGGCAACACAATAA
ATGCCATCGTCTGATACCCCTGAATGGGGACTAAAATGTGCCGTCACTCCGCGATTCGGAGCCAGATTGGTGCAGGAAGG
TCACCGTCTGCACTATCTGGCAGACCGTGCCAGCATTGTCGGTACGTTTAGCAAAACAGAAGCCCAAAGTCTGGAACGTT
GCTTCCCTGAGCTAATTAAGCTGTTGGAACAGAAGCTACGCATGGGGGAACTGAATCCCCGTCAGCAGAACTGCGTCACG
CTGCATTGCAACGAATGGATCTGTGAAGCCGATACGCTGGGCAGTGTTGGCTACGTGTATATTGTTATCTATCCCTCTTC
TGCGGCAACACAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| PDB | 7R5A |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| PDB | 7R5A | |
| PDB | 7B22 | |
| AlphaFold DB | A0A151JFU4 |