Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-Phd |
| Location | 68489..69067 | Replicon | chromosome |
| Accession | NZ_CP046845 | ||
| Organism | Vibrio cholerae C6706 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | O68848 |
| Locus tag | GPY04_RS14620 | Protein ID | WP_001180243.1 |
| Coordinates | 68750..69067 (+) | Length | 106 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | Q7DCR7 |
| Locus tag | GPY04_RS14615 | Protein ID | WP_000557292.1 |
| Coordinates | 68489..68731 (+) | Length | 81 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GPY04_RS14565 | 63914..63952 | - | 39 | WP_106019119.1 | hypothetical protein | - |
| GPY04_RS14570 | 63968..64093 | - | 126 | WP_001944767.1 | DUF645 family protein | - |
| GPY04_RS19380 | 64270..64380 | - | 111 | WP_134814058.1 | DUF3265 domain-containing protein | - |
| GPY04_RS14580 | 64377..64694 | - | 318 | WP_001232701.1 | HigA family addiction module antidote protein | - |
| GPY04_RS14585 | 64705..64992 | - | 288 | WP_001162670.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| GPY04_RS14590 | 65259..65439 | - | 181 | Protein_115 | DUF645 family protein | - |
| GPY04_RS14595 | 65864..66097 | - | 234 | WP_032482776.1 | DUF3709 domain-containing protein | - |
| GPY04_RS14600 | 66500..66718 | - | 219 | WP_001917086.1 | DUF3709 domain-containing protein | - |
| GPY04_RS14605 | 67028..67681 | - | 654 | WP_000226874.1 | hypothetical protein | - |
| GPY04_RS14610 | 67738..68247 | - | 510 | WP_000405987.1 | GNAT family N-acetyltransferase | - |
| GPY04_RS14615 | 68489..68731 | + | 243 | WP_000557292.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| GPY04_RS14620 | 68750..69067 | + | 318 | WP_001180243.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| GPY04_RS19385 | 69261..69356 | - | 96 | WP_001907607.1 | DUF645 family protein | - |
| GPY04_RS14630 | 69712..70005 | - | 294 | WP_125460920.1 | hypothetical protein | - |
| GPY04_RS14640 | 70152..70499 | - | 348 | WP_000933409.1 | hypothetical protein | - |
| GPY04_RS14645 | 70648..71073 | - | 426 | WP_000403014.1 | GNAT family N-acetyltransferase | - |
| GPY04_RS14650 | 71269..71448 | - | 180 | WP_001883039.1 | DUF645 family protein | - |
| GPY04_RS14655 | 71745..72281 | - | 537 | WP_000644491.1 | nucleotidyltransferase family protein | - |
| GPY04_RS14660 | 72425..72820 | - | 396 | WP_000046953.1 | hypothetical protein | - |
| GPY04_RS14665 | 72997..73178 | - | 182 | Protein_129 | DUF645 family protein | - |
| GPY04_RS14670 | 73481..73876 | - | 396 | WP_000046952.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integron | catB9 | hlyA / vgrG-3 / vasL / icmF/vasK / vasJ / vasI / vasH / clpB/vasG / vasF / vasE / vasD / vasC / vasB / vasA / VCA0109 / vipB/mglB / vipA/mglA / vgrG-2 / hcp-2 / hlyA / htpB / ugd / cqsA | 113..1070288 | 1070175 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 106 a.a. Molecular weight: 12158.97 Da Isoelectric Point: 9.7495
>T145085 WP_001180243.1 NZ_CP046845:68750-69067 [Vibrio cholerae C6706]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS
Download Length: 318 bp
>T145085 NZ_CP062254:3699683-3699988 [Pectobacterium parmentieri]
ATGCAATTCATTGTTTATGAATACAAACGAGCCAGCCACTACAAAATTTTTGTCGATGTGCAGAGTGATATTGTCGAGAC
ACCCAAGCGACGCATGGTCATCCCGCTTATCGAAGCACATCATCTGTCTGAGAAAGTGAATAAAACATTGTTCCCGCTGC
TCCGCATCGACGGCGAAGATTATCGGCTGATGACCACTGAGCTATCGAGCGTTCCCGTTGAGGTCATTGGTGAAGTGATT
GTGGATCTCAGCGACTACGCGGATGAGATCAAGGATGCTATCAATCTTATGTTTTGGGGGATTTGA
ATGCAATTCATTGTTTATGAATACAAACGAGCCAGCCACTACAAAATTTTTGTCGATGTGCAGAGTGATATTGTCGAGAC
ACCCAAGCGACGCATGGTCATCCCGCTTATCGAAGCACATCATCTGTCTGAGAAAGTGAATAAAACATTGTTCCCGCTGC
TCCGCATCGACGGCGAAGATTATCGGCTGATGACCACTGAGCTATCGAGCGTTCCCGTTGAGGTCATTGGTGAAGTGATT
GTGGATCTCAGCGACTACGCGGATGAGATCAAGGATGCTATCAATCTTATGTTTTGGGGGATTTGA
Antitoxin
Download Length: 81 a.a. Molecular weight: 8961.25 Da Isoelectric Point: 5.6630
>AT145085 WP_000557292.1 NZ_CP046845:68489-68731 [Vibrio cholerae C6706]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL
Download Length: 243 bp
>AT145085 NZ_CP062254:3699462-3699680 [Pectobacterium parmentieri]
ATGAAACACCGCGTCAGCGTTACCGTAGACAAAGACAATTATCAGGTTCTGAGTGCTGCCGGAGTCAATATTTCCGGGCT
GGTGAATGACGCCATTGGCAAAGAAGCCCGTCGCATCAAGGCTGAGGAGTGGAAGAAGGAAAACCGCGAAGGGATGGAAG
AAGTCGCCCGATTTATCGCGCAGCATGGCTCCTTTGCAGATGAAAACAGGAACTGGTGA
ATGAAACACCGCGTCAGCGTTACCGTAGACAAAGACAATTATCAGGTTCTGAGTGCTGCCGGAGTCAATATTTCCGGGCT
GGTGAATGACGCCATTGGCAAAGAAGCCCGTCGCATCAAGGCTGAGGAGTGGAAGAAGGAAAACCGCGAAGGGATGGAAG
AAGTCGCCCGATTTATCGCGCAGCATGGCTCCTTTGCAGATGAAAACAGGAACTGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0K9UJR8 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | Q7DCR7 |