Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 34593..35121 Replicon chromosome
Accession NZ_CP046845
Organism Vibrio cholerae C6706

Toxin (Protein)


Gene name relE Uniprot ID H9L4R3
Locus tag GPY04_RS14295 Protein ID WP_000221352.1
Coordinates 34831..35121 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID H9L4T4
Locus tag GPY04_RS14290 Protein ID WP_000213183.1
Coordinates 34593..34841 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPY04_RS14245 29632..30096 + 465 WP_000140244.1 hypothetical protein -
GPY04_RS14250 30196..30594 - 399 WP_001882293.1 hypothetical protein -
GPY04_RS14255 30750..31250 - 501 WP_000789723.1 hypothetical protein -
GPY04_RS14260 31388..31918 - 531 WP_000415563.1 hypothetical protein -
GPY04_RS14265 32069..32464 - 396 WP_000649527.1 DUF3465 domain-containing protein -
GPY04_RS14270 32672..33097 - 426 WP_000415748.1 hypothetical protein -
GPY04_RS14275 33369..34022 - 654 WP_000036957.1 site-specific DNA-methyltransferase -
GPY04_RS14290 34593..34841 + 249 WP_000213183.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GPY04_RS14295 34831..35121 + 291 WP_000221352.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GPY04_RS14300 35257..35772 - 516 WP_001201528.1 lipocalin family protein -
GPY04_RS14305 35909..36385 - 477 WP_001047180.1 GNAT family N-acetyltransferase -
GPY04_RS14310 36413..36523 - 111 WP_071917832.1 DUF3265 domain-containing protein -
GPY04_RS14315 36520..37449 - 930 WP_000335802.1 hypothetical protein -
GPY04_RS14320 37569..38015 - 447 WP_000128977.1 hypothetical protein -
GPY04_RS14325 38168..39172 - 1005 WP_000964925.1 LD-carboxypeptidase -
GPY04_RS19360 39385..39423 - 39 WP_106019119.1 hypothetical protein -
GPY04_RS19365 39439..39564 - 126 WP_001944767.1 DUF645 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron catB9 hlyA / vgrG-3 / vasL / icmF/vasK / vasJ / vasI / vasH / clpB/vasG / vasF / vasE / vasD / vasC / vasB / vasA / VCA0109 / vipB/mglB / vipA/mglA / vgrG-2 / hcp-2 / hlyA / htpB / ugd / cqsA 113..1070288 1070175


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11247.23 Da        Isoelectric Point: 10.4678

>T145083 WP_000221352.1 NZ_CP046845:34831-35121 [Vibrio cholerae C6706]
MTYKLEFKKSALKEWKKLAVPLQQQFKKKLIERLENPHVPSAKLSGAENIYKIKLRQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD

Download         Length: 291 bp

>T145083 NZ_CP062254:c1464627-1464307 [Pectobacterium parmentieri]
ATGCAAACATCACCGGCAATCCCGCCACGGGAGGATAACCCCTGTCCGTCACCTATAGCCGTCTGGCAGCAACTACTGAC
TTACCTGCTGGAAAAGCACTACGGCCTGACGCTGAACGACACACCATTCTGTGAGGAAAACGTGATTCAGGAGCATATCG
ATGCTGGCATCACGCTGGCCAATGCCGTCAATTTTCTGGTGGAGAAATACGAACTGGTGCGTATCGATCGCAACGGCTTT
AACTGGCAGGAGCAATCGCCGTTTCTTACCGCCGTTGATGTTCTCCGTGCTAGACGTGCAACGGGCTTGCTCAAGGCATA
A

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8937.28 Da        Isoelectric Point: 4.1079

>AT145083 WP_000213183.1 NZ_CP046845:34593-34841 [Vibrio cholerae C6706]
MTTRILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPASTYEIMMDKLEDLELLAIAKERLSEDSVSVNID
DL

Download         Length: 249 bp

>AT145083 NZ_CP062254:c1465032-1464697 [Pectobacterium parmentieri]
ATGCCATCATCGGATACCCCGGAGTGGGGATTAAAATGTGCCATCACGCCGCGATTCGGAGCCAGGCTGGTCCAGGAAGG
ACACCGCCTGCATTATCTGGAAGACCGGGCCAGCATTGTCGGTACGTTCAGCGAAATGGAAGCCCACCATCTGGAAGAGA
TCTTTCCTGAGCTGATTAAGCAGTTGGAACAAAAACTGCGCTCGGGTGAGTTGAATCCCCGTCAGCGGGGTTGCGTCACG
CTGTATTGTAACGAATGGACCTGTGAAGCCGATACGCTGGGCAGTTTTGGTTATGTATATATTGTTATTTATCCCACTTC
TGCAGCAACACACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB H9L4R3

Antitoxin

Source ID Structure
AlphaFold DB A0A366A3W8

References