Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mosAT/AbiEii-AbiEi |
| Location | 1030225..1031947 | Replicon | chromosome |
| Accession | NZ_CP046840 | ||
| Organism | Vibrio cholerae strain F9993 | ||
Toxin (Protein)
| Gene name | mosT | Uniprot ID | D0FZT9 |
| Locus tag | GPY07_RS04590 | Protein ID | WP_000356587.1 |
| Coordinates | 1030225..1031163 (-) | Length | 313 a.a. |
Antitoxin (Protein)
| Gene name | mosA | Uniprot ID | A0A934MVJ4 |
| Locus tag | GPY07_RS04595 | Protein ID | WP_000095577.1 |
| Coordinates | 1031156..1031947 (-) | Length | 264 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GPY07_RS04570 | 1026166..1026678 | - | 513 | WP_001166556.1 | S26 family signal peptidase | - |
| GPY07_RS04575 | 1026662..1027009 | - | 348 | WP_001044650.1 | hypothetical protein | - |
| GPY07_RS04580 | 1027002..1029401 | - | 2400 | WP_000648041.1 | type IV secretion system protein TraC | - |
| GPY07_RS04585 | 1029401..1030093 | - | 693 | WP_001228924.1 | DsbC family protein | - |
| GPY07_RS04590 | 1030225..1031163 | - | 939 | WP_000356587.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
| GPY07_RS04595 | 1031156..1031947 | - | 792 | WP_000095577.1 | type IV toxin-antitoxin system AbiEi family antitoxin | Antitoxin |
| GPY07_RS04600 | 1032168..1032554 | - | 387 | WP_000180225.1 | hypothetical protein | - |
| GPY07_RS04605 | 1032551..1033123 | - | 573 | WP_139057167.1 | type IV conjugative transfer system lipoprotein TraV | - |
| GPY07_RS04610 | 1033198..1034487 | - | 1290 | WP_001883765.1 | TraB/VirB10 family protein | - |
| GPY07_RS04615 | 1034490..1035386 | - | 897 | WP_032467354.1 | type-F conjugative transfer system secretin TraK | - |
| GPY07_RS04620 | 1035370..1035996 | - | 627 | WP_000667169.1 | hypothetical protein | - |
| GPY07_RS04625 | 1035993..1036274 | - | 282 | WP_000433889.1 | type IV conjugative transfer system protein TraL | - |
| GPY07_RS04630 | 1036455..1036778 | + | 324 | WP_000118545.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | sul2 / aph(3'')-Ib / aph(6)-Id / floR / dfrA18 | - | 944860..1092902 | 148042 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 313 a.a. Molecular weight: 35548.82 Da Isoelectric Point: 4.9081
>T145054 WP_000356587.1 NZ_CP046840:c1031163-1030225 [Vibrio cholerae]
MDKDSPYYKQVSLLIRMLPVVATETVFALKGGTAINLFVRDFPRLSVDIDLAYLPLEPRDEALINVRAALQRITDRINTQ
PDIRAAFQDNKADELRIVVSSPVATIKIEVSPVARGTLHSAEIMPVQESVEDEFGYAEIQVVSLPDLYGGKLCAAMDRQH
PRDLFDVRMLLGSEGISREILVGFLTYTLSHPRPINEVMSPNWQPLNEKFQAEFDGMTFEKVECEDLASVRPMMLIELQK
HFTERDHAFLMSFKRGQPDWALFDYPNAADLPAIRWKLQNINKLAKNQAKHQEQLDKLKQVLDDWLVNANAE
MDKDSPYYKQVSLLIRMLPVVATETVFALKGGTAINLFVRDFPRLSVDIDLAYLPLEPRDEALINVRAALQRITDRINTQ
PDIRAAFQDNKADELRIVVSSPVATIKIEVSPVARGTLHSAEIMPVQESVEDEFGYAEIQVVSLPDLYGGKLCAAMDRQH
PRDLFDVRMLLGSEGISREILVGFLTYTLSHPRPINEVMSPNWQPLNEKFQAEFDGMTFEKVECEDLASVRPMMLIELQK
HFTERDHAFLMSFKRGQPDWALFDYPNAADLPAIRWKLQNINKLAKNQAKHQEQLDKLKQVLDDWLVNANAE
Download Length: 939 bp
>T145054 NZ_CP062251:3543616-3543900 [Pseudomonas sp. IzPS59]
CTGCCGCTTGAATGGAGCGAACAAGCTCTGGACGATCTGGCTGACATTATCGATTACGTTGAACAATACAACTCAAACGC
TTCAACGGCTCTGCAGCACAAGGTTGGTGCAGCAACGCAAAGGCTTTCATCAATTCCTTATGGTTACCGGTCCGGTCGAG
TGCCAGGCACTCGGGAAATGGTGGTCAATCCGAACTATCTGCTGGTCTATCGAGTGAACGGGCGCATCAAAATACTGACG
TTAGTCCACACCCGACGACAATACCCACGAACCTCATCAACCTAA
CTGCCGCTTGAATGGAGCGAACAAGCTCTGGACGATCTGGCTGACATTATCGATTACGTTGAACAATACAACTCAAACGC
TTCAACGGCTCTGCAGCACAAGGTTGGTGCAGCAACGCAAAGGCTTTCATCAATTCCTTATGGTTACCGGTCCGGTCGAG
TGCCAGGCACTCGGGAAATGGTGGTCAATCCGAACTATCTGCTGGTCTATCGAGTGAACGGGCGCATCAAAATACTGACG
TTAGTCCACACCCGACGACAATACCCACGAACCTCATCAACCTAA
Antitoxin
Download Length: 264 a.a. Molecular weight: 30109.49 Da Isoelectric Point: 9.5097
>AT145054 WP_000095577.1 NZ_CP046840:c1031947-1031156 [Vibrio cholerae]
MSSKINWLVAHTSPGALVLQQWLTENGVSYSLAQKYAQNGWLKKLSSGVYYRPNAQGDIKPTWVDAIQALDVQLGVPVHL
AGLSSLTHQGLSHYLQLNKEQVWICVKNKSSLPKWFREFPYQNWFYCGNHKLEVNPEKDLKRITVKEKELTVSCAELAAY
EVVDAIGKLISFEHVAELFQGLVNLSPRKVQDILERSSSVQANRIFLFLGRYYDHQWVNRIDETRIKLGAGKRQVVEKGR
FDERYQITVPEILSVKKGEQHNG
MSSKINWLVAHTSPGALVLQQWLTENGVSYSLAQKYAQNGWLKKLSSGVYYRPNAQGDIKPTWVDAIQALDVQLGVPVHL
AGLSSLTHQGLSHYLQLNKEQVWICVKNKSSLPKWFREFPYQNWFYCGNHKLEVNPEKDLKRITVKEKELTVSCAELAAY
EVVDAIGKLISFEHVAELFQGLVNLSPRKVQDILERSSSVQANRIFLFLGRYYDHQWVNRIDETRIKLGAGKRQVVEKGR
FDERYQITVPEILSVKKGEQHNG
Download Length: 792 bp
>AT145054 NZ_CP062251:3543432-3543626 [Pseudomonas sp. IzPS59]
ATGAGCATATTGCATTCCCCGTTTTACTCTGACTTCGACTCCGAAGAAGAGGCAGAGAGCTACGATCGCTGGTTTCGTGC
CAAGGTGCAGGAGGCACTGGATGATCCTAATCCGGGCATTCCCCATGAAGAAGCCATGATGCGGCTCGACCAACTATTAG
AAGAGAGACGCAAGAATCGACGCGCTGCCGCTTGA
ATGAGCATATTGCATTCCCCGTTTTACTCTGACTTCGACTCCGAAGAAGAGGCAGAGAGCTACGATCGCTGGTTTCGTGC
CAAGGTGCAGGAGGCACTGGATGATCCTAATCCGGGCATTCCCCATGAAGAAGCCATGATGCGGCTCGACCAACTATTAG
AAGAGAGACGCAAGAATCGACGCGCTGCCGCTTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|