Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc(toxin)
Location 833627..834198 Replicon chromosome
Accession NZ_CP046838
Organism Vibrio cholerae strain 2011EL-1271

Toxin (Protein)


Gene name doc Uniprot ID Q9KMA2
Locus tag GPY01_RS03870 Protein ID WP_000351248.1
Coordinates 833627..834028 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID Q8GNG3
Locus tag GPY01_RS03875 Protein ID WP_001080654.1
Coordinates 834028..834198 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPY01_RS03835 829227..829712 - 486 WP_123161806.1 hypothetical protein -
GPY01_RS03840 829857..830234 - 378 WP_123161807.1 hypothetical protein -
GPY01_RS03845 830390..830968 - 579 WP_000461673.1 DUF2726 domain-containing protein -
GPY01_RS03850 831225..832211 + 987 WP_001170900.1 sulfate ABC transporter substrate-binding protein -
GPY01_RS03855 832392..832832 - 441 WP_001966102.1 DUF1311 domain-containing protein -
GPY01_RS03860 833118..833354 - 237 WP_032481679.1 DUF3709 domain-containing protein -
GPY01_RS03865 833514..833657 - 144 WP_075042602.1 DUF3265 domain-containing protein -
GPY01_RS03870 833627..834028 - 402 WP_000351248.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
GPY01_RS03875 834028..834198 - 171 WP_001080654.1 hypothetical protein Antitoxin
GPY01_RS03880 834386..834730 - 345 WP_032471989.1 hypothetical protein -
GPY01_RS03885 834892..835392 - 501 WP_032471962.1 hypothetical protein -
GPY01_RS03890 835538..836053 - 516 WP_057645600.1 lipocalin family protein -
GPY01_RS03895 836080..836169 - 90 WP_072615218.1 DUF3265 domain-containing protein -
GPY01_RS03900 836187..836798 - 612 WP_054104030.1 hypothetical protein -
GPY01_RS03905 837016..837246 + 231 WP_000838533.1 PAS factor family protein -
GPY01_RS03910 837436..838260 - 825 WP_080281735.1 HNH endonuclease -
GPY01_RS03915 838233..838322 - 90 WP_123161809.1 acetyltransferase -
GPY01_RS03920 838379..838756 - 378 WP_123161810.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 781659..859428 77769
- inside Integron - - 781069..851868 70799


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(1-132)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14608.71 Da        Isoelectric Point: 4.0128

>T145050 WP_000351248.1 NZ_CP046838:c834028-833627 [Vibrio cholerae]
MDIICFPFERVIEINAFILKTEPGMKGAVDIPKLQGALGRIDNAIVYEGLDDVFEIAAKYTACIAVSHALPDANKRTGLA
VALEYLSLNDFELTQENDLLADAVRDLVIGIINETDFADILYAQYAKEQNSAL

Download         Length: 402 bp

>T145050 NZ_CP062251:485323-485610 [Pseudomonas sp. IzPS59]
ATGACCGAACAATTCACTCGTTGGGACTCAGCCGAGTACCTCAAGACAGAAGAGGACATGGCCAACTATCTGGACGCCTG
TATGGAGGAGGCGGGTGACGACCCGGCTTTTATTGCCAAGGCACTTGGCACTATCGCTCGGGCGCGTGGCATGACCCAGG
TCGCGCGCGATGCAGGGCTGTCACGGGAAAGTCTTTATCGCGCACTGTCAGGCGAGGTAAATCCCGAGTTTGGAACGATC
CTCAAAGTCATGAAAGCGCTGGGCCTGAAGTTGCACGCCAGCACATGA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6287.35 Da        Isoelectric Point: 10.7274

>AT145050 WP_001080654.1 NZ_CP046838:c834198-834028 [Vibrio cholerae]
MNRKVEAYGVDAVERPKIKASKKLDLTGDAGRQIVKSETKLALRTHQKTFTKLADM

Download         Length: 171 bp

>AT145050 NZ_CP062251:485021-485326 [Pseudomonas sp. IzPS59]
ATGACTGAGATACTTCGAAGCTCCACATTCTCGAGCTGGCTTGTGAAGCTGGCTGATAGTCGCGCCAGGATGCGTATTCA
GGTGCGAATTGATCGCATGGCTGATGGGAATTTCGGTGATGTCAAAGCCATTGGCGAAGGGATCAGCGAAGCCCGAATTG
ACTATGGCCCGGGATATCGGGTCTATTTCATGCAGCAAGGTCGTCAGCTGGTCATCCTCCTTTGCGGTGGAGACAAGAGC
AGTCAATCTCGAGACATCAAGCAAGCCAGGCTCATCGCGGAATCCTGGCAGGAGCAAAACCCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Q0PN34

Antitoxin

Source ID Structure
AlphaFold DB A0A1T4SJJ1

References