Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/RelE-RelB |
| Location | 827363..827922 | Replicon | chromosome |
| Accession | NZ_CP046838 | ||
| Organism | Vibrio cholerae strain 2011EL-1271 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | D2YI11 |
| Locus tag | GPY01_RS03820 | Protein ID | WP_000578473.1 |
| Coordinates | 827644..827922 (+) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | - |
| Locus tag | GPY01_RS03815 | Protein ID | WP_000381186.1 |
| Coordinates | 827363..827647 (+) | Length | 95 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GPY01_RS03770 | 822548..822706 | - | 159 | Protein_730 | VOC family protein | - |
| GPY01_RS03775 | 822733..823860 | - | 1128 | WP_032470627.1 | ISAs1 family transposase | - |
| GPY01_RS03780 | 824028..824111 | - | 84 | Protein_732 | GNAT family N-acetyltransferase | - |
| GPY01_RS03785 | 824268..824555 | - | 288 | WP_000869988.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| GPY01_RS03790 | 824552..824833 | - | 282 | WP_032471913.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| GPY01_RS03795 | 825166..825399 | - | 234 | WP_080033909.1 | DUF3709 domain-containing protein | - |
| GPY01_RS03800 | 825420..825590 | - | 171 | Protein_736 | hypothetical protein | - |
| GPY01_RS03805 | 825596..825871 | - | 276 | Protein_737 | ISAs1 family transposase | - |
| GPY01_RS03810 | 825894..827020 | - | 1127 | Protein_738 | ISAs1 family transposase | - |
| GPY01_RS03815 | 827363..827647 | + | 285 | WP_000381186.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| GPY01_RS03820 | 827644..827922 | + | 279 | WP_000578473.1 | type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family | Toxin |
| GPY01_RS03825 | 828121..828300 | - | 180 | Protein_741 | DUF645 family protein | - |
| GPY01_RS03830 | 828597..829125 | - | 529 | Protein_742 | GNAT family N-acetyltransferase | - |
| GPY01_RS03835 | 829227..829712 | - | 486 | WP_123161806.1 | hypothetical protein | - |
| GPY01_RS03840 | 829857..830234 | - | 378 | WP_123161807.1 | hypothetical protein | - |
| GPY01_RS03845 | 830390..830968 | - | 579 | WP_000461673.1 | DUF2726 domain-containing protein | - |
| GPY01_RS03850 | 831225..832211 | + | 987 | WP_001170900.1 | sulfate ABC transporter substrate-binding protein | - |
| GPY01_RS03855 | 832392..832832 | - | 441 | WP_001966102.1 | DUF1311 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 781659..859428 | 77769 | |
| - | inside | IScluster/Tn | - | - | 822733..827020 | 4287 | |
| - | inside | Integron | - | - | 781069..851868 | 70799 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10868.59 Da Isoelectric Point: 4.6794
>T145049 WP_000578473.1 NZ_CP046838:827644-827922 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAEKTDELIETKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND
MIFWEEASLNDREKIFEFLYDFNPAAAEKTDELIETKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND
Download Length: 279 bp
>T145049 NZ_CP062251:485021-485326 [Pseudomonas sp. IzPS59]
ATGACTGAGATACTTCGAAGCTCCACATTCTCGAGCTGGCTTGTGAAGCTGGCTGATAGTCGCGCCAGGATGCGTATTCA
GGTGCGAATTGATCGCATGGCTGATGGGAATTTCGGTGATGTCAAAGCCATTGGCGAAGGGATCAGCGAAGCCCGAATTG
ACTATGGCCCGGGATATCGGGTCTATTTCATGCAGCAAGGTCGTCAGCTGGTCATCCTCCTTTGCGGTGGAGACAAGAGC
AGTCAATCTCGAGACATCAAGCAAGCCAGGCTCATCGCGGAATCCTGGCAGGAGCAAAACCCATGA
ATGACTGAGATACTTCGAAGCTCCACATTCTCGAGCTGGCTTGTGAAGCTGGCTGATAGTCGCGCCAGGATGCGTATTCA
GGTGCGAATTGATCGCATGGCTGATGGGAATTTCGGTGATGTCAAAGCCATTGGCGAAGGGATCAGCGAAGCCCGAATTG
ACTATGGCCCGGGATATCGGGTCTATTTCATGCAGCAAGGTCGTCAGCTGGTCATCCTCCTTTGCGGTGGAGACAAGAGC
AGTCAATCTCGAGACATCAAGCAAGCCAGGCTCATCGCGGAATCCTGGCAGGAGCAAAACCCATGA
Antitoxin
Download Length: 95 a.a. Molecular weight: 10915.28 Da Isoelectric Point: 8.0775
>AT145049 WP_000381186.1 NZ_CP046838:827363-827647 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFVEHDIAKVR
MAERKAKIRNRGHA
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFVEHDIAKVR
MAERKAKIRNRGHA
Download Length: 285 bp
>AT145049 NZ_CP062251:485323-485610 [Pseudomonas sp. IzPS59]
ATGACCGAACAATTCACTCGTTGGGACTCAGCCGAGTACCTCAAGACAGAAGAGGACATGGCCAACTATCTGGACGCCTG
TATGGAGGAGGCGGGTGACGACCCGGCTTTTATTGCCAAGGCACTTGGCACTATCGCTCGGGCGCGTGGCATGACCCAGG
TCGCGCGCGATGCAGGGCTGTCACGGGAAAGTCTTTATCGCGCACTGTCAGGCGAGGTAAATCCCGAGTTTGGAACGATC
CTCAAAGTCATGAAAGCGCTGGGCCTGAAGTTGCACGCCAGCACATGA
ATGACCGAACAATTCACTCGTTGGGACTCAGCCGAGTACCTCAAGACAGAAGAGGACATGGCCAACTATCTGGACGCCTG
TATGGAGGAGGCGGGTGACGACCCGGCTTTTATTGCCAAGGCACTTGGCACTATCGCTCGGGCGCGTGGCATGACCCAGG
TCGCGCGCGATGCAGGGCTGTCACGGGAAAGTCTTTATCGCGCACTGTCAGGCGAGGTAAATCCCGAGTTTGGAACGATC
CTCAAAGTCATGAAAGCGCTGGGCCTGAAGTTGCACGCCAGCACATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|