Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 824268..824833 Replicon chromosome
Accession NZ_CP046838
Organism Vibrio cholerae strain 2011EL-1271

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag GPY01_RS03785 Protein ID WP_000869988.1
Coordinates 824268..824555 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag GPY01_RS03790 Protein ID WP_032471913.1
Coordinates 824552..824833 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPY01_RS03740 819268..819612 - 345 WP_032471989.1 hypothetical protein -
GPY01_RS03745 819732..820229 - 498 WP_032471926.1 hypothetical protein -
GPY01_RS03750 820391..821086 - 696 WP_032471927.1 hypothetical protein -
GPY01_RS03755 821094..821705 - 612 WP_032471928.1 DUF4433 domain-containing protein -
GPY01_RS03760 821886..822113 - 228 WP_123161804.1 cysteine-rich CWC family protein -
GPY01_RS03770 822548..822706 - 159 Protein_730 VOC family protein -
GPY01_RS03775 822733..823860 - 1128 WP_032470627.1 ISAs1 family transposase -
GPY01_RS03780 824028..824111 - 84 Protein_732 GNAT family N-acetyltransferase -
GPY01_RS03785 824268..824555 - 288 WP_000869988.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GPY01_RS03790 824552..824833 - 282 WP_032471913.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GPY01_RS03795 825166..825399 - 234 WP_080033909.1 DUF3709 domain-containing protein -
GPY01_RS03800 825420..825590 - 171 Protein_736 hypothetical protein -
GPY01_RS03805 825596..825871 - 276 Protein_737 ISAs1 family transposase -
GPY01_RS03810 825894..827020 - 1127 Protein_738 ISAs1 family transposase -
GPY01_RS03815 827363..827647 + 285 WP_000381186.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
GPY01_RS03820 827644..827922 + 279 WP_000578473.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
GPY01_RS03825 828121..828300 - 180 Protein_741 DUF645 family protein -
GPY01_RS03830 828597..829125 - 529 Protein_742 GNAT family N-acetyltransferase -
GPY01_RS03835 829227..829712 - 486 WP_123161806.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 781659..859428 77769
- inside IScluster/Tn - - 822733..827020 4287
- inside Integron - - 781069..851868 70799


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(9-74)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11059.77 Da        Isoelectric Point: 6.0710

>T145048 WP_000869988.1 NZ_CP046838:c824555-824268 [Vibrio cholerae]
MKVVWSPLALQKLGDAAEFIAFDNPSAAERWVNEVFDKTELLGSMPEMGRMVPEMPHTNYREIIFGHYRIIYSLSHEIRV
LTVRNCRQLLTEHDV

Download         Length: 288 bp

>T145048 NZ_CP062251:350779-350961 [Pseudomonas sp. IzPS59]
ATGAAGTACAGCGAGTTTCGGCGATGGTTGAAAGCCCAAGGCGTTGAGTTCCAAACCGGCAAGGGCAGCCATTTCAAGGT
TTCCTTGAATGGCAGATCAACTGTCTTTCCCGACCACGGAGCCAAGGAAATGGGCGAAGGGTTGAGAAAATCGATAATCA
AACAGCTGGGACTCAAGGATTGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10375.96 Da        Isoelectric Point: 5.1548

>AT145048 WP_032471913.1 NZ_CP046838:c824833-824552 [Vibrio cholerae]
MSRIHLDQDIQPLSEFRAGVASFIKQINETRRPLVITQRGKGVAVVLDVAEYEVMQEKIELLEEMRTAEAQLAAGLGVSN
EDARSQVLGRIIK

Download         Length: 282 bp

>AT145048 NZ_CP062251:350993-351418 [Pseudomonas sp. IzPS59]
ATGTTCGAATATGCGTTGGAAGTCCACGAAGAGCCGGGCAGTGTCTGGTTGTCCTGCGCAGAAATTCCAGAGATGCACGC
CGCTGGCGACACTCTTGAGGAAGCACTCGACGGCGCCATTGATGCAATGGAGACGGCTCTGTCGATTTACGTAGATGATC
GCCGGTTGATTCCGACAGGTGATGCGGGAGAGCAGGAAAGTGACGCTGTTTTGCGTCTGCCTGCACTGACTGCGGCAAAG
GTTGGGCTCTGGAATACGCTTCTGGAGTCTGGGGTCAGCAAAGCTGAACTGGCGCGCCGTTTGGGGGTGCAGCGGCCCCA
GGTAGATCGGTTAGTCGATTTCCTTCATCACTCCAAGATCGAGAATGTCGAGCGAGCGTTGCAGCAGCTCGGGCGGCGGA
TTTTGCTTTCGGTTGAGGCTGCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References