Detailed information of TA system TA145046

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-Phd
• Location: 811681..812259
• Replicon: chromosome
• Accession: NZ_CP046838
• Organism: Vibrio cholerae strain 2011EL-1271

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: GPY01_RS03670
• Protein ID: WP_001180238.1
• Coordinates: 811942..812259 (+)
• Length: 106 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A366AI09
• Locus tag: GPY01_RS03665
• Protein ID: WP_000557291.1
• Coordinates: 811681..811923 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GPY01_RS03605	806821..807138	+	318	WP_032471951.1	CcdB family protein	-
GPY01_RS03610	807255..807680	-	426	WP_119567070.1	GNAT family N-acetyltransferase	-
GPY01_RS03615	807824..808180	-	357	WP_001094969.1	hypothetical protein	-
GPY01_RS03620	808343..808783	-	441	WP_001966102.1	DUF1311 domain-containing protein	-
GPY01_RS18750	808827..808937	-	111	WP_080308943.1	DUF3265 domain-containing protein	-
GPY01_RS03630	808934..809251	-	318	WP_001232701.1	HigA family addiction module antidote protein	-
GPY01_RS03635	809262..809549	-	288	WP_001162670.1	type II toxin-antitoxin system RelE/ParE family toxin	-
GPY01_RS03640	809843..810085	+	243	WP_001107720.1	type II toxin-antitoxin system ParD family antitoxin	-
GPY01_RS03645	810082..810381	+	300	WP_000802136.1	type II toxin-antitoxin system RelE/ParE family toxin	-
GPY01_RS03655	810498..810980	-	483	WP_032471903.1	GNAT family N-acetyltransferase	-
GPY01_RS03660	811007..811132	-	126	WP_001973975.1	DUF3265 domain-containing protein	-
GPY01_RS03665	811681..811923	+	243	WP_000557291.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
GPY01_RS03670	811942..812259	+	318	WP_001180238.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GPY01_RS03675	812395..812709	-	315	WP_000071011.1	DNA-binding transcriptional regulator	-
GPY01_RS03680	812696..813028	-	333	WP_000843587.1	type II toxin-antitoxin system RelE/ParE family toxin	-
GPY01_RS03685	813219..813515	-	297	WP_001069046.1	hypothetical protein	-
GPY01_RS03690	813653..814078	-	426	WP_119567070.1	GNAT family N-acetyltransferase	-
GPY01_RS03695	814213..814638	-	426	WP_119567070.1	GNAT family N-acetyltransferase	-
GPY01_RS03700	814774..815514	-	741	WP_032471918.1	PhzF family phenazine biosynthesis protein	-
GPY01_RS03705	815570..815680	-	111	Protein_718	DUF3265 domain-containing protein	-
GPY01_RS03710	815677..816036	-	360	WP_001071517.1	VOC family protein	-
GPY01_RS03715	816277..816426	-	150	WP_050498152.1	DUF645 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	781659..859428	77769
	-	inside	Integron	-	-	781069..851868	70799

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-93)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-71)

Sequences

Toxin

Protein

• Length: 106 a.a.
• Molecular weight: 12169.01 Da
• Isoelectric Point: 9.7495

>T145046 WP_001180238.1 NZ_CP046838:811942-812259 [Vibrio cholerae]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKPTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Nucleotide

• Length: 318 bp

>T145046 NZ_CP062250:c4523870-4523613 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8931.22 Da
• Isoelectric Point: 5.6630

>AT145046 WP_000557291.1 NZ_CP046838:811681-811923 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGAAFLNTL

Nucleotide

• Length: 243 bp

>AT145046 NZ_CP062250:c4523601-4523056 [Escherichia coli]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA

Structures

Antitoxin

• AlphaFold DB: A0A366AI09