Detailed information of TA system TA145043

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 796392..796957
• Replicon: chromosome
• Accession: NZ_CP046838
• Organism: Vibrio cholerae strain 2011EL-1271

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: GPY01_RS03505
• Protein ID: WP_000869988.1
• Coordinates: 796392..796679 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: GPY01_RS03510
• Protein ID: WP_032471913.1
• Coordinates: 796676..796957 (-)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GPY01_RS03470	791444..791941	-	498	WP_000259916.1	GNAT family N-acetyltransferase	-
GPY01_RS03475	792097..792432	-	336	WP_032471914.1	hypothetical protein	-
GPY01_RS03480	792584..792778	-	195	Protein_675	hypothetical protein	-
GPY01_RS03485	792801..793928	-	1128	WP_032470627.1	ISAs1 family transposase	-
GPY01_RS03495	794857..795984	-	1128	WP_032470627.1	ISAs1 family transposase	-
GPY01_RS03500	796152..796235	-	84	Protein_678	GNAT family N-acetyltransferase	-
GPY01_RS03505	796392..796679	-	288	WP_000869988.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GPY01_RS03510	796676..796957	-	282	WP_032471913.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
GPY01_RS03515	797290..797523	-	234	WP_080033909.1	DUF3709 domain-containing protein	-
GPY01_RS03520	797544..797714	-	171	Protein_682	hypothetical protein	-
GPY01_RS03525	797720..797995	-	276	Protein_683	ISAs1 family transposase	-
GPY01_RS03530	798018..799144	-	1127	Protein_684	ISAs1 family transposase	-
GPY01_RS03535	799355..799477	-	123	Protein_685	DUF645 family protein	-
GPY01_RS03540	799833..800014	-	182	Protein_686	DUF645 family protein	-
GPY01_RS03545	800200..800322	-	123	Protein_687	DUF3265 domain-containing protein	-
GPY01_RS03550	800793..801038	+	246	WP_001260801.1	type II toxin-antitoxin system CcdA family antitoxin	-
GPY01_RS03555	801038..801355	+	318	WP_032471951.1	CcdB family protein	-
GPY01_RS03565	801603..801863	-	261	WP_161403747.1	DUF3709 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	781659..859428	77769
	-	inside	IScluster/Tn	-	-	792801..799144	6343
	-	inside	Integron	-	-	781069..851868	70799

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-74)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11059.77 Da
• Isoelectric Point: 6.0710

>T145043 WP_000869988.1 NZ_CP046838:c796679-796392 [Vibrio cholerae]
MKVVWSPLALQKLGDAAEFIAFDNPSAAERWVNEVFDKTELLGSMPEMGRMVPEMPHTNYREIIFGHYRIIYSLSHEIRV
LTVRNCRQLLTEHDV

Nucleotide

• Length: 288 bp

>T145043 NZ_CP062250:c3693447-3693340 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10375.96 Da
• Isoelectric Point: 5.1548

>AT145043 WP_032471913.1 NZ_CP046838:c796957-796676 [Vibrio cholerae]
MSRIHLDQDIQPLSEFRAGVASFIKQINETRRPLVITQRGKGVAVVLDVAEYEVMQEKIELLEEMRTAEAQLAAGLGVSN
EDARSQVLGRIIK

Nucleotide

• Length: 282 bp

>AT145043 NZ_CP062250:3693496-3693562 [Escherichia coli]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC