Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 790678..791243 Replicon chromosome
Accession NZ_CP046838
Organism Vibrio cholerae strain 2011EL-1271

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag GPY01_RS03460 Protein ID WP_000869988.1
Coordinates 790678..790965 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag GPY01_RS03465 Protein ID WP_032471913.1
Coordinates 790962..791243 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPY01_RS03405 785845..786423 - 579 WP_000461673.1 DUF2726 domain-containing protein -
GPY01_RS03410 786699..786977 - 279 WP_032471925.1 DUF3709 domain-containing protein -
GPY01_RS03415 786962..787147 - 186 Protein_664 hypothetical protein -
GPY01_RS03420 787204..787407 - 204 WP_001933740.1 hypothetical protein -
GPY01_RS03430 787745..787975 + 231 WP_000838533.1 PAS factor family protein -
GPY01_RS03435 788171..788671 - 501 WP_032471962.1 hypothetical protein -
GPY01_RS18740 788869..788907 - 39 WP_139151257.1 hypothetical protein -
GPY01_RS03440 788914..789051 - 138 WP_002022145.1 DUF645 family protein -
GPY01_RS03445 789346..789735 - 390 WP_001081302.1 hypothetical protein -
GPY01_RS03460 790678..790965 - 288 WP_000869988.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GPY01_RS03465 790962..791243 - 282 WP_032471913.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GPY01_RS03470 791444..791941 - 498 WP_000259916.1 GNAT family N-acetyltransferase -
GPY01_RS03475 792097..792432 - 336 WP_032471914.1 hypothetical protein -
GPY01_RS03480 792584..792778 - 195 Protein_675 hypothetical protein -
GPY01_RS03485 792801..793928 - 1128 WP_032470627.1 ISAs1 family transposase -
GPY01_RS03495 794857..795984 - 1128 WP_032470627.1 ISAs1 family transposase -
GPY01_RS03500 796152..796235 - 84 Protein_678 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 781659..859428 77769
- inside IScluster/Tn - - 792801..799144 6343
- inside Integron - - 781069..851868 70799


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(9-74)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11059.77 Da        Isoelectric Point: 6.0710

>T145042 WP_000869988.1 NZ_CP046838:c790965-790678 [Vibrio cholerae]
MKVVWSPLALQKLGDAAEFIAFDNPSAAERWVNEVFDKTELLGSMPEMGRMVPEMPHTNYREIIFGHYRIIYSLSHEIRV
LTVRNCRQLLTEHDV

Download         Length: 288 bp

>T145042 NZ_CP062250:3270696-3271160 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAAACAGAAGAAACCCATTGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10375.96 Da        Isoelectric Point: 5.1548

>AT145042 WP_032471913.1 NZ_CP046838:c791243-790962 [Vibrio cholerae]
MSRIHLDQDIQPLSEFRAGVASFIKQINETRRPLVITQRGKGVAVVLDVAEYEVMQEKIELLEEMRTAEAQLAAGLGVSN
EDARSQVLGRIIK

Download         Length: 282 bp

>AT145042 NZ_CP062250:3270361-3270696 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References