Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 1336506..1337034 Replicon chromosome
Accession NZ_CP046835
Organism Vibrio vulnificus strain 07-2444

Toxin (Protein)


Gene name relE Uniprot ID K5TRR0
Locus tag GPY41_RS14430 Protein ID WP_005377002.1
Coordinates 1336744..1337034 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A193KIL6
Locus tag GPY41_RS14425 Protein ID WP_017028225.1
Coordinates 1336506..1336754 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPY41_RS14375 1332126..1332244 - 119 Protein_1350 DUF3265 domain-containing protein -
GPY41_RS14385 1332587..1332715 - 129 WP_154186728.1 DUF3265 domain-containing protein -
GPY41_RS14390 1333191..1333538 - 348 WP_043886964.1 hypothetical protein -
GPY41_RS14395 1333697..1334032 - 336 WP_039445746.1 hypothetical protein -
GPY41_RS14405 1334601..1334723 - 123 WP_080721564.1 DUF3265 domain-containing protein -
GPY41_RS14410 1334733..1335113 - 381 WP_158123510.1 GFA family protein -
GPY41_RS14420 1335787..1336308 - 522 WP_158123511.1 GNAT family N-acetyltransferase -
GPY41_RS24440 1336363..1336431 - 69 WP_074531725.1 DUF3265 domain-containing protein -
GPY41_RS14425 1336506..1336754 + 249 WP_017028225.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GPY41_RS14430 1336744..1337034 + 291 WP_005377002.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GPY41_RS14435 1337703..1337870 - 168 WP_199252259.1 DUF3265 domain-containing protein -
GPY41_RS14440 1338213..1338309 - 97 Protein_1361 DUF3265 domain-containing protein -
GPY41_RS14445 1338338..1338775 - 438 WP_158123512.1 hypothetical protein -
GPY41_RS14450 1338795..1338887 - 93 WP_193283032.1 DUF3265 domain-containing protein -
GPY41_RS14455 1338913..1339695 - 783 WP_119464782.1 hypothetical protein -
GPY41_RS14460 1339688..1339834 - 147 WP_158124244.1 DUF3265 domain-containing protein -
GPY41_RS14465 1340301..1340933 - 633 WP_158123513.1 hypothetical protein -
GPY41_RS14470 1340949..1341071 - 123 WP_158124245.1 DUF3265 domain-containing protein -
GPY41_RS14475 1341421..1341561 - 141 WP_158123514.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - - 1150341..1350499 200158


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(12-75)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11261.25 Da        Isoelectric Point: 10.5932

>T145040 WP_005377002.1 NZ_CP046835:1336744-1337034 [Vibrio vulnificus]
MTYKLDFKKSALKEWKKLGSTLQQQFKKKLIERLDNPHVPASKLSGADNMYKIKLRQSGYRLVYKVEDDVIIVTVLAVGK
RERSDVYRKAMKRLDD

Download         Length: 291 bp

>T145040 NZ_CP062250:c3161903-3161607 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9061.33 Da        Isoelectric Point: 3.9610

>AT145040 WP_017028225.1 NZ_CP046835:1336506-1336754 [Vibrio vulnificus]
MTTRILADVAASITELKANPMKVATSAYGEPVAVLNRNEPAFYCVPAEAYEMMIDRLEDLELLAIAKERESEESISVNID
DL

Download         Length: 249 bp

>AT145040 NZ_CP062250:c3161605-3161210 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A347UR03

Antitoxin

Source ID Structure
AlphaFold DB A0A193KIL6

References