Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 1180982..1181748 Replicon chromosome
Accession NZ_CP046835
Organism Vibrio vulnificus strain 07-2444

Toxin (Protein)


Gene name - Uniprot ID A0A432DAA5
Locus tag GPY41_RS12805 Protein ID WP_017053840.1
Coordinates 1181251..1181748 (+) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A347UQX1
Locus tag GPY41_RS12800 Protein ID WP_017420534.1
Coordinates 1180982..1181254 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPY41_RS12745 1176082..1176315 - 234 WP_158123396.1 hypothetical protein -
GPY41_RS12750 1176473..1176820 - 348 WP_043886964.1 hypothetical protein -
GPY41_RS12755 1176836..1176970 - 135 WP_158124166.1 DUF3265 domain-containing protein -
GPY41_RS12760 1176973..1177410 - 438 WP_039470159.1 hypothetical protein -
GPY41_RS12765 1177429..1177818 - 390 WP_158123397.1 hypothetical protein -
GPY41_RS12770 1177851..1177997 - 147 WP_158124167.1 DUF3265 domain-containing protein -
GPY41_RS24395 1178358..1178450 - 93 WP_079748754.1 DUF3265 domain-containing protein -
GPY41_RS12780 1178476..1178925 - 450 WP_140136491.1 hypothetical protein -
GPY41_RS12785 1179555..1180280 - 726 WP_053543510.1 DUF4241 domain-containing protein -
GPY41_RS12790 1180298..1180420 - 123 WP_086467490.1 DUF3265 domain-containing protein -
GPY41_RS24400 1180780..1180941 - 162 WP_199252247.1 DUF3265 domain-containing protein -
GPY41_RS12800 1180982..1181254 + 273 WP_017420534.1 DUF1778 domain-containing protein Antitoxin
GPY41_RS12805 1181251..1181748 + 498 WP_017053840.1 GNAT family N-acetyltransferase Toxin
GPY41_RS12810 1181905..1182222 - 318 WP_158124169.1 phosphotyrosine protein phosphatase -
GPY41_RS12815 1182241..1182396 - 156 Protein_1056 DUF3265 domain-containing protein -
GPY41_RS12820 1182463..1183434 + 972 WP_026138241.1 IS30 family transposase -
GPY41_RS12825 1183457..1184062 - 606 WP_158123399.1 hypothetical protein -
GPY41_RS12830 1184213..1184881 - 669 WP_158123400.1 hypothetical protein -
GPY41_RS12835 1185031..1185408 - 378 WP_017052519.1 hypothetical protein -
GPY41_RS12840 1185617..1185967 - 351 WP_199252222.1 GFA family protein -
GPY41_RS24405 1185992..1186114 - 123 Protein_1062 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1182502..1183434 932
- inside Integron - - 1150341..1350499 200158


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18458.12 Da        Isoelectric Point: 8.8085

>T145036 WP_017053840.1 NZ_CP046835:1181251-1181748 [Vibrio vulnificus]
MMNTVLLDKAKHDRNRFNCGIEALNNYLKVMASQQAKKDNTRTFVLEDDSDNSHVIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADV
RASLG

Download         Length: 498 bp

>T145036 NZ_CP062250:2759277-2760350 [Escherichia coli]
ATGACAATCAGGAGTTACAAAAACTTAAATCTGGTCAGGGCAAATATCGAGACTGAATCCAGACAATTCATTGAAAATAA
AAACTATTCAATCCAATCAATTGGTCCTATGCCAGGGTCAAGGGCTGGGCTTCGGGTCGTATTTACCAGACCAGGGGTTA
ACTTGGCAACTGTGGACATTTTTTATAACGGGGACGGTTCGACTACAATTCAATATCTCACTGGAGCCAATCGTTCTCTG
GGCCAAGAGTTAGCGGATCATCTTTTTGAAACCATCAATCCTGCTGAATTTGAGCAGGTAAATATGGTACTGCAAGGATT
TGTAGAGACAAGCGTTCTACCTGTACTTGAGCTATCAGCAGATGAATCGCATATAGAGTTCAGAGAACACTCTCGTAACG
CTCATACCGTAGTGTGGAAAATTATTTCCACCAGCTATCAGGACGAATTGACTGTGAGCCTGCATATCACAACAGGTAAG
CTCCAGATTCAGGGCCGACCGCTGTCATGTTACAGAGTTTTCACGTTTAACTTGGCAGCCCTGCTTGATTTACAGGGTTT
GGAGAAAGTGCTAATCCGCCAGGAGGATGGTAAAGCTAATATTGTTCAACAGGAGGTTGCCCGCACTTACTTGCAGACTG
TAATGGCCGATGCTTACCCGCATCTCCACGTGACTGCCGAAAAATTGCTCGTTTCAGGGCTATGTGTTAAACTCGCCGCC
CCTGATTTGCCTGACTACTGTATGTTACTTTATCCTGAACTACGCACCATTGAAGGTGTCTTAAAAAGTAAGATGAGTGG
GTTAGGCATGCCAGTACAGCAGCCGGCAGGTTTTGGAACTTACTTTGATAAACCTGCTGCTCATTACATTCTGAAACCGC
AATTTGCAGCTACTCTTAGACCGGAACAGATTAACATCATCAGCACAGCCTATACTTTTTTTAATGTGGAACGTCATTCT
CTGTTCCACATGGAAACTGTGGTCGATGCCAGCCGTATGATTTCTGATATGGCCCGGTTGATGGGTAAAGCCACTAGAGC
GTGGGGAATAATCAAGGACTTATATATTGTTTGA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9735.22 Da        Isoelectric Point: 8.5960

>AT145036 WP_017420534.1 NZ_CP046835:1180982-1181254 [Vibrio vulnificus]
MATTLPRITARVDVDTQDLLTKAAAIAGMSSINSFVLSAAIEKAKQVIEREQALKLSQADAMLLMEALDRPATQNSKLKA
AADRYESKTQ

Download         Length: 273 bp

>AT145036 NZ_CP062250:2760343-2760714 [Escherichia coli]
TTGTTTGAAATCACCGGAATTAACGTCTCAGGGGCTCTAAAAGCTGTCGTTATGGCGACCGGCTTCGAGAACCCTTTGTC
CTCAGTTAATGAAATTGAGACGAAACTTTCTGCCCTACTGGGTAGTGAGACCACTGGTGAAATCCTTTTTGACCTCTTGT
GCGCTAACGGTCCAGAGTGGAACCGCTTCGTTACGCTGGAAATGAAATATGGCCGGATCATGCTGGATACGGCCAAAATT
ATTGATGAGCAGGACGTTCCGACACATATCCTGAGCAAACTGACTTTTACTTTACGTAATCATCCTGAGTACCTAGAAGC
CTCTGTTTTGTCTCCCGATGATGTACGCCAAGTCCTGTCAATGGATTTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A432DAA5

Antitoxin

Source ID Structure
AlphaFold DB A0A347UQX1

References