Detailed information of TA system TA145034

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 663320..663879
• Replicon: chromosome
• Accession: NZ_CP046834
• Organism: Vibrio vulnificus strain 07-2444

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: GPY41_RS02815
• Protein ID: WP_158122276.1
• Coordinates: 663601..663879 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A3Q0L0M2
• Locus tag: GPY41_RS02810
• Protein ID: WP_011082348.1
• Coordinates: 663320..663604 (+)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GPY41_RS02780	658776..659801	+	1026	WP_197672410.1	L-threonine 3-dehydrogenase	-
GPY41_RS02785	659873..660289	-	417	WP_158122976.1	hypothetical protein	-
GPY41_RS02790	660384..660914	-	531	WP_158122274.1	hypothetical protein	-
GPY41_RS02795	661195..661695	-	501	WP_158122275.1	hypothetical protein	-
GPY41_RS02800	661773..662036	-	264	WP_011082346.1	hypothetical protein	-
GPY41_RS02805	662277..663086	-	810	WP_039452822.1	SUMF1/EgtB/PvdO family nonheme iron enzyme	-
GPY41_RS02810	663320..663604	+	285	WP_011082348.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
GPY41_RS02815	663601..663879	+	279	WP_158122276.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GPY41_RS02820	663908..664000	-	93	WP_080933905.1	DUF3265 domain-containing protein	-
GPY41_RS02825	664320..664574	-	255	Protein_553	hypothetical protein	-
GPY41_RS02830	664584..664955	-	372	WP_130200969.1	hypothetical protein	-
GPY41_RS02835	665213..665365	-	153	WP_158122977.1	DUF3265 domain-containing protein	-
GPY41_RS02840	665362..665787	-	426	WP_158122278.1	hypothetical protein	-
GPY41_RS02845	666409..666909	-	501	WP_015727541.1	hypothetical protein	-
GPY41_RS02850	667184..667699	-	516	WP_038939963.1	lipocalin family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-89)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-45)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10969.71 Da
• Isoelectric Point: 4.3430

>T145034 WP_158122276.1 NZ_CP046834:663601-663879 [Vibrio vulnificus]
MILWEEESLNDREKIFEFLYDFNPDAAEKTDNLIEAKVENLLEQPLMGVQRDGIRGRLLMIPEISMVIFYWVEGDIIRVM
RVLHQKQKFPTD

Nucleotide

• Length: 279 bp

>T145034 NZ_CP062250:c2082946-2082692 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 11083.43 Da
• Isoelectric Point: 9.2167

>AT145034 WP_011082348.1 NZ_CP046834:663320-663604 [Vibrio vulnificus]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFIEHQTAKSR
MEERKARIRNRGKQ

Nucleotide

• Length: 285 bp

>AT145034 NZ_CP062250:c2083194-2082943 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Structures

Antitoxin

• AlphaFold DB: A0A3Q0L0M2