Detailed information of TA system TA145032

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafN(antitoxin)
• Location: 1543304..1543869
• Replicon: chromosome
• Accession: NZ_CP046832
• Organism: Vibrio vulnificus strain 06-2410

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: GPY16_RS07390
• Protein ID: WP_199245008.1
• Coordinates: 1543582..1543869 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: U3BLE1
• Locus tag: GPY16_RS07385
• Protein ID: WP_000086647.1
• Coordinates: 1543304..1543585 (+)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GPY16_RS07340	1538951..1539097	+	147	WP_158105577.1	DUF3265 domain-containing protein	-
GPY16_RS07345	1539154..1539501	+	348	WP_017036770.1	DUF3024 domain-containing protein	-
GPY16_RS07350	1539516..1539626	+	111	WP_193784268.1	DUF3265 domain-containing protein	-
GPY16_RS07355	1539664..1540722	+	1059	WP_158105194.1	hypothetical protein	-
GPY16_RS07360	1540857..1541555	+	699	WP_158105195.1	hypothetical protein	-
GPY16_RS07365	1541567..1541848	+	282	WP_158105578.1	DUF3265 domain-containing protein	-
GPY16_RS07370	1542483..1542800	-	318	WP_017420671.1	CcdB family protein	-
GPY16_RS07375	1542800..1543045	-	246	WP_024703869.1	type II toxin-antitoxin system CcdA family antitoxin	-
GPY16_RS07380	1543102..1543347	+	246	WP_158105579.1	DUF3265 domain-containing protein	-
GPY16_RS07385	1543304..1543585	+	282	WP_000086647.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
GPY16_RS07390	1543582..1543869	+	288	WP_199245008.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GPY16_RS22425	1543897..1543989	+	93	WP_196334564.1	DUF3265 domain-containing protein	-
GPY16_RS07400	1544349..1544471	+	123	WP_081372735.1	DUF3265 domain-containing protein	-
GPY16_RS07405	1544493..1545113	+	621	WP_058666957.1	hypothetical protein	-
GPY16_RS07410	1545207..1545644	+	438	WP_158105196.1	GNAT family N-acetyltransferase	-
GPY16_RS07415	1545662..1545823	+	162	WP_158105580.1	DUF3265 domain-containing protein	-
GPY16_RS07420	1545893..1546114	+	222	WP_017420735.1	VF530 family protein	-
GPY16_RS07425	1546124..1546246	+	123	WP_158105581.1	DUF3265 domain-containing protein	-
GPY16_RS07430	1546269..1546745	+	477	WP_053339495.1	GNAT family N-acetyltransferase	-
GPY16_RS07435	1546730..1546852	+	123	WP_079853917.1	DUF3265 domain-containing protein	-
GPY16_RS07440	1546879..1547178	+	300	WP_005526314.1	hypothetical protein	-
GPY16_RS07445	1547914..1548348	+	435	WP_023623449.1	hypothetical protein	-
GPY16_RS07450	1548327..1548761	+	435	WP_080540688.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1486330..1553242	66912
	-	inside	Integron	-	-	1485122..1548348	63226

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-74)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11057.73 Da
• Isoelectric Point: 4.8177

>T145032 WP_199245008.1 NZ_CP046832:1543582-1543869 [Vibrio vulnificus]
MKVVWSPLALQKLGDAAEFISLDNPPAAERWVNEVFDKTELLGSMPEMGRFVPEMPHTNYREIIFGYYRIIYSLSHEIRV
LTVRNCRQILSEDDV

Nucleotide

• Length: 288 bp

>T145032 NZ_CP062250:c1917464-1917361 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10398.91 Da
• Isoelectric Point: 5.8650

>AT145032 WP_000086647.1 NZ_CP046832:1543304-1543585 [Vibrio vulnificus]
MSRIHFDQDIQPLSEFRAGVASYIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLASGLGVSN
DDARAQVLGRIKK

Nucleotide

• Length: 282 bp

>AT145032 NZ_CP062250:1917323-1917594 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Structures

Antitoxin

• AlphaFold DB: A0A4P8G0X0