Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 1537870..1538408 Replicon chromosome
Accession NZ_CP046832
Organism Vibrio vulnificus strain 06-2410

Toxin (Protein)


Gene name parE Uniprot ID A0A3Q0L5T8
Locus tag GPY16_RS07330 Protein ID WP_001247271.1
Coordinates 1537870..1538169 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A0F2HR74
Locus tag GPY16_RS07335 Protein ID WP_011080384.1
Coordinates 1538166..1538408 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPY16_RS22420 1533441..1533530 + 90 WP_080256077.1 DUF3265 domain-containing protein -
GPY16_RS07280 1533558..1534073 + 516 WP_061778615.1 GNAT family N-acetyltransferase -
GPY16_RS07285 1534098..1534190 + 93 WP_193783841.1 DUF3265 domain-containing protein -
GPY16_RS07290 1534274..1534933 + 660 WP_158105192.1 hypothetical protein -
GPY16_RS07295 1535135..1535854 + 720 WP_103154437.1 hypothetical protein -
GPY16_RS07300 1535869..1535961 + 93 WP_193783763.1 DUF3265 domain-containing protein -
GPY16_RS07305 1536010..1536318 + 309 WP_017420768.1 hypothetical protein -
GPY16_RS07310 1536336..1536443 + 108 WP_158105575.1 DUF3265 domain-containing protein -
GPY16_RS07315 1536775..1536909 + 135 WP_103196065.1 DUF3265 domain-containing protein -
GPY16_RS07320 1537042..1537245 + 204 WP_158105193.1 hypothetical protein -
GPY16_RS07325 1537715..1537909 + 195 WP_199245007.1 DUF3265 domain-containing protein -
GPY16_RS07330 1537870..1538169 - 300 WP_001247271.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GPY16_RS07335 1538166..1538408 - 243 WP_011080384.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
GPY16_RS07340 1538951..1539097 + 147 WP_158105577.1 DUF3265 domain-containing protein -
GPY16_RS07345 1539154..1539501 + 348 WP_017036770.1 DUF3024 domain-containing protein -
GPY16_RS07350 1539516..1539626 + 111 WP_193784268.1 DUF3265 domain-containing protein -
GPY16_RS07355 1539664..1540722 + 1059 WP_158105194.1 hypothetical protein -
GPY16_RS07360 1540857..1541555 + 699 WP_158105195.1 hypothetical protein -
GPY16_RS07365 1541567..1541848 + 282 WP_158105578.1 DUF3265 domain-containing protein -
GPY16_RS07370 1542483..1542800 - 318 WP_017420671.1 CcdB family protein -
GPY16_RS07375 1542800..1543045 - 246 WP_024703869.1 type II toxin-antitoxin system CcdA family antitoxin -
GPY16_RS07380 1543102..1543347 + 246 WP_158105579.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1486330..1553242 66912
- flank IS/Tn - - 1532355..1532990 635
- inside Integron - - 1485122..1548348 63226


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-78)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11703.39 Da        Isoelectric Point: 9.9572

>T145031 WP_001247271.1 NZ_CP046832:c1538169-1537870 [Vibrio vulnificus]
MRPFQLTNKAKSDLRDIALFTSRRWGREQRNIYLKQFDDSFWLLAENPDIGKACDEIRDGYRKFPQGSHVIFYRQIGSQN
IEIIRILHKSMDVNPIFGA

Download         Length: 300 bp

>T145031 NZ_CP062250:c1639890-1639603 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8953.88 Da        Isoelectric Point: 4.2213

>AT145031 WP_011080384.1 NZ_CP046832:c1538408-1538166 [Vibrio vulnificus]
MAKNTSITLGDHFDGFIANQIQSGRYGSASEVIRSALRLLETQETKMNTLRQLLVEGEESGVADYDLDSFINELDSEERK

Download         Length: 243 bp

>AT145031 NZ_CP062250:c1640129-1639890 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Q0L5T8

Antitoxin

Source ID Structure
AlphaFold DB A0A0F2HR74

References