Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafN(antitoxin)
Location 1518868..1519433 Replicon chromosome
Accession NZ_CP046832
Organism Vibrio vulnificus strain 06-2410

Toxin (Protein)


Gene name relE Uniprot ID A0A7X8U0A9
Locus tag GPY16_RS07135 Protein ID WP_029865673.1
Coordinates 1519146..1519433 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID U3BLE1
Locus tag GPY16_RS07130 Protein ID WP_000086647.1
Coordinates 1518868..1519149 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPY16_RS07070 1513925..1514146 + 222 WP_017420735.1 VF530 family protein -
GPY16_RS07075 1514150..1514293 + 144 Protein_1332 DUF3265 domain-containing protein -
GPY16_RS07080 1514303..1514992 + 690 WP_158105178.1 DUF4145 domain-containing protein -
GPY16_RS07090 1516268..1516360 + 93 WP_080252015.1 DUF3265 domain-containing protein -
GPY16_RS07095 1516393..1516836 + 444 WP_140166732.1 hypothetical protein -
GPY16_RS07100 1516805..1517035 + 231 WP_158105180.1 DUF3265 domain-containing protein -
GPY16_RS07105 1517016..1517333 - 318 WP_158105181.1 YceK/YidQ family lipoprotein -
GPY16_RS07110 1517660..1517890 - 231 WP_011150352.1 PAS factor family protein -
GPY16_RS07115 1517971..1518093 + 123 WP_078535084.1 DUF3265 domain-containing protein -
GPY16_RS07120 1518105..1518659 + 555 WP_158105182.1 hypothetical protein -
GPY16_RS22410 1518699..1518788 + 90 Protein_1342 DUF3265 domain-containing protein -
GPY16_RS07130 1518868..1519149 + 282 WP_000086647.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GPY16_RS07135 1519146..1519433 + 288 WP_029865673.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GPY16_RS07140 1520410..1520532 + 123 WP_139127769.1 DUF3265 domain-containing protein -
GPY16_RS07145 1520572..1520991 + 420 WP_038938879.1 RDD family protein -
GPY16_RS07150 1521009..1521110 + 102 WP_080581988.1 DUF3265 domain-containing protein -
GPY16_RS07155 1521136..1521477 + 342 WP_158105184.1 hypothetical protein -
GPY16_RS07160 1521511..1521588 + 78 WP_085050488.1 DUF3265 domain-containing protein -
GPY16_RS07165 1521632..1522048 + 417 WP_025510445.1 VOC family protein -
GPY16_RS07170 1522082..1522159 + 78 WP_074534512.1 DUF3265 domain-containing protein -
GPY16_RS07175 1522204..1523208 + 1005 WP_158105185.1 LD-carboxypeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1486330..1553242 66912
- inside Integron - - 1485122..1548348 63226


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(9-74)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10993.65 Da        Isoelectric Point: 5.1098

>T145030 WP_029865673.1 NZ_CP046832:1519146-1519433 [Vibrio vulnificus]
MKVVWSPLALQKLGDAAEFISLDNPSAAEKWVNEVFDKTELLGSMPEMGRFVPEMPHTNYREIIFGHYRIIYSLSHEIRV
LTVRNCRQILSEDDV

Download         Length: 288 bp

>T145030 NZ_CP062250:c1586433-1585111 [Escherichia coli]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCAAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CTGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCCAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTGACGTTAATACCCGAAGA
CGAAACCGTAACGCATCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGACTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCGCTAGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCACAGGAGAAGACAGCACTG
CTCAGAATAGGCAATGACTGGTGCATTCCGAAAGGAATAACGCCGACGACGCACATCATTAAATTACCGATTGGCGAAAT
CAGGCAGCCCAATGCGACGCTCGATCTCAGCCAAAGCGTTGATAATGAGTATTACTGTCTGCTGCTGGCGAAAGAACTTG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAATGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATGCTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGTCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCAGGCATCGCGCGGATCATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAATTCCAGGTCTTCCAGTGGTTGATTGGCGCAACGGACGGTCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTTTGGCGACAGCAAAGGTGCTGAGATTCCCGGAAGTGCAGATGCATGAAATCCTGAGTGACTTTGCCAGAATGATTCCA
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAAGCAATGTGTT
GAGGTTGCATGGACGGTTAAGCCGAGAATACGGTAGTAAGTGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10398.91 Da        Isoelectric Point: 5.8650

>AT145030 WP_000086647.1 NZ_CP046832:1518868-1519149 [Vibrio vulnificus]
MSRIHFDQDIQPLSEFRAGVASYIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLASGLGVSN
DDARAQVLGRIKK

Download         Length: 282 bp

>AT145030 NZ_CP062250:c1586699-1586433 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTGGCGAATGCAATGAAACTGGTTCGCCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATTGGTATTAAGCAGGCGACGATTTCCAATTTCGAAAACAACCCTGACAATACCACGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACGCTATGCGACGCGAAAAATGCCTCGCCAGAATCA
ACAGAACAGCAAAATCTGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7X8U0A9

Antitoxin

Source ID Structure
AlphaFold DB A0A4P8G0X0

References