Detailed information of TA system TA145029

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PanAT/DUF4065(antitoxin)
• Location: 3431488..3433142
• Replicon: chromosome
• Accession: NZ_CP046831
• Organism: Vibrio parahaemolyticus strain 2012AW-0224

Toxin (Protein)

• Gene name: panT
• Uniprot ID: -
• Locus tag: GPY55_RS26560
• Protein ID: WP_158163617.1
• Coordinates: 3431952..3433142 (+)
• Length: 397 a.a.

Antitoxin (Protein)

• Gene name: panA
• Uniprot ID: -
• Locus tag: GPY55_RS26555
• Protein ID: WP_005378671.1
• Coordinates: 3431488..3431955 (+)
• Length: 156 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GPY55_RS26525	3426616..3426837	-	222	WP_031847865.1	AlpA family transcriptional regulator	-
GPY55_RS26530	3426915..3427904	+	990	WP_031847866.1	50S ribosome-binding GTPase	-
GPY55_RS26535	3428014..3428460	+	447	WP_031847867.1	hypothetical protein	-
GPY55_RS26540	3428501..3429145	-	645	WP_031847868.1	inovirus Gp2 family protein	-
GPY55_RS26545	3429312..3430433	-	1122	WP_031847869.1	hypothetical protein	-
GPY55_RS26550	3430488..3431159	+	672	WP_083135736.1	hypothetical protein	-
GPY55_RS26555	3431488..3431955	+	468	WP_005378671.1	DUF4065 domain-containing protein	Antitoxin
GPY55_RS26560	3431952..3433142	+	1191	WP_158163617.1	RelA/SpoT domain-containing protein	Toxin
GPY55_RS26565	3433335..3434444	-	1110	WP_031847871.1	tRNA (uridine(54)-C5)-methyltransferase TrmA	-
GPY55_RS26570	3434888..3436762	+	1875	WP_024703592.1	TonB-dependent receptor	-
GPY55_RS26575	3436841..3437524	+	684	WP_031847872.1	ATPase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3418151..3433142	14991

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RelA/SpoT (111-217)

Antitoxin

• Antitoxin SocA-like, Panacea domain (32-123)

Sequences

Toxin

Protein

• Length: 397 a.a.
• Molecular weight: 44625.14 Da
• Isoelectric Point: 5.2387

>T145029 WP_158163617.1 NZ_CP046831:3431952-3433142 [Vibrio parahaemolyticus]
VSNKENSVVSFYIDDTPTAEQASKTFQDDYELDFQDFIERTVNESAAEDFSYSNNGVKKAGRRLRKREGDLKSATATIQQ
FRAAHEKPLNTIAYLVGRCCRELGIDVKPVTRLKRLETIVDKLQRKSLDGETANATCVTNMNDIGGCRAIFPDLISLEKV
GRVRIKDIDDYITSPKPNDCGYRSLHVIYRYDHASGKSFNIEAQLRTRLQHLWATTVEIVDILEGTKIKTHSHSSNEGKS
SLQVQWEELLSIMSQYIADAEGAIELSDIDKADFSKRLVVLDREINALNRLSSFKILSEKVNSYCDSSIEHVLLVINETS
RELIFSEEFENYSQAISVYNAAEKVTRSYSRATSRLNTLLISTKNMGQLSEAYPNYLGDCASFITLLEDAMLSGES

Nucleotide

• Length: 1191 bp

>T145029 NZ_CP062250:1503543-1503719 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin

Protein

• Length: 156 a.a.
• Molecular weight: 17516.97 Da
• Isoelectric Point: 7.9061

>AT145029 WP_005378671.1 NZ_CP046831:3431488-3431955 [Vibrio parahaemolyticus]
MKAYHTYSAVDVAWSLLKHAKEQGKCFSNLQLQKLTYVCHGLSLAHFQRPLVVDDVFAWKFGPVVPSVYFRFKSYGSSVI
TEQCDVALDQESESIVKDVVSKLGHLTGPQLVDLTHREGSPWHQVWDGTHQKVIPDHLIQAHYTQIKQSGRTASL

Nucleotide

• Length: 468 bp

>AT145029 NZ_CP062250:1503765-1504181 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA