Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 1795133..1795661 Replicon chromosome
Accession NZ_CP046831
Organism Vibrio parahaemolyticus strain 2012AW-0224

Toxin (Protein)


Gene name relE Uniprot ID K5TRR0
Locus tag GPY55_RS18525 Protein ID WP_005377002.1
Coordinates 1795371..1795661 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A347UR02
Locus tag GPY55_RS18520 Protein ID WP_005377003.1
Coordinates 1795133..1795381 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPY55_RS18470 1790252..1790344 - 93 WP_010448843.1 DUF3265 domain-containing protein -
GPY55_RS18475 1790375..1791736 - 1362 WP_083135194.1 multidrug transporter -
GPY55_RS18480 1791746..1791835 - 90 WP_079740859.1 DUF3265 domain-containing protein -
GPY55_RS18485 1792463..1792999 - 537 WP_025558159.1 hypothetical protein -
GPY55_RS18490 1793066..1793128 - 63 WP_193235574.1 DUF3265 domain-containing protein -
GPY55_RS18495 1793143..1793562 - 420 WP_083135204.1 GNAT family N-acetyltransferase -
GPY55_RS18500 1793794..1794288 - 495 WP_031848041.1 GNAT family N-acetyltransferase -
GPY55_RS18505 1794321..1794413 - 93 WP_071936844.1 DUF3265 domain-containing protein -
GPY55_RS18510 1794439..1794918 - 480 WP_139794910.1 hypothetical protein -
GPY55_RS18515 1794990..1795058 - 69 WP_083135206.1 DUF3265 domain-containing protein -
GPY55_RS18520 1795133..1795381 + 249 WP_005377003.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GPY55_RS18525 1795371..1795661 + 291 WP_005377002.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GPY55_RS18530 1795680..1795772 - 93 WP_005534950.1 DUF3265 domain-containing protein -
GPY55_RS18535 1795787..1796281 - 495 WP_025630543.1 hypothetical protein -
GPY55_RS18540 1796317..1796409 - 93 WP_079879064.1 DUF3265 domain-containing protein -
GPY55_RS18545 1796424..1797224 - 801 WP_031848071.1 HNH endonuclease -
GPY55_RS18550 1797253..1797345 - 93 WP_074534468.1 DUF3265 domain-containing protein -
GPY55_RS18555 1797360..1797893 - 534 WP_031847662.1 hypothetical protein -
GPY55_RS18560 1798107..1798463 - 357 WP_031847663.1 hypothetical protein -
GPY55_RS18565 1799033..1799188 - 156 WP_083135207.1 DUF3265 domain-containing protein -
GPY55_RS18575 1799580..1799672 - 93 WP_080101997.1 DUF3265 domain-containing protein -
GPY55_RS18580 1799701..1800075 - 375 WP_031848047.1 hypothetical protein -
GPY55_RS18585 1800113..1800205 - 93 WP_080936824.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - - 1671550..1825309 153759


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(12-75)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11261.25 Da        Isoelectric Point: 10.5932

>T145028 WP_005377002.1 NZ_CP046831:1795371-1795661 [Vibrio parahaemolyticus]
MTYKLDFKKSALKEWKKLGSTLQQQFKKKLIERLDNPHVPASKLSGADNMYKIKLRQSGYRLVYKVEDDVIIVTVLAVGK
RERSDVYRKAMKRLDD

Download         Length: 291 bp

>T145028 NZ_CP062250:c1408184-1407990 [Escherichia coli]
ATGAGATATGACAATGTTAAACCATGTCCATTTTGTGGTTGTCCATCAGTAACGGTGAAAGCCATTTCAGGATATTACCG
AGCGAAGTGTAACGGATGCGAATCCCGAACCGGTTATGGTGGAAGTGAAAAAGAAGCACTCGAAAGATGGAATAAACGAA
CCACTGGAAATAATAATGGAGGTGTTCATGTATAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9079.37 Da        Isoelectric Point: 3.9610

>AT145028 WP_005377003.1 NZ_CP046831:1795133-1795381 [Vibrio parahaemolyticus]
MTTRILADVAASITELKANPMKVATSAYGEPVAVLNRNEPAFYCVPAEAYEMMMDRLEDLELLAIAKERESEESISVNID
DL

Download         Length: 249 bp

>AT145028 NZ_CP062250:1407813-1407991 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A347UR03

Antitoxin

Source ID Structure
AlphaFold DB A0A347UR02

References