Detailed information of TA system TA145027

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 1777918..1778446
• Replicon: chromosome
• Accession: NZ_CP046831
• Organism: Vibrio parahaemolyticus strain 2012AW-0224

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: GPY55_RS18360
• Protein ID: WP_029853447.1
• Coordinates: 1778156..1778446 (+)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A347UR02
• Locus tag: GPY55_RS18355
• Protein ID: WP_005377003.1
• Coordinates: 1777918..1778166 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GPY55_RS18290	1773390..1773506	-	117	WP_083135707.1	DUF3265 domain-containing protein	-
GPY55_RS18295	1773497..1773961	-	465	WP_031848022.1	GNAT family N-acetyltransferase	-
GPY55_RS18300	1773994..1774131	-	138	WP_083135705.1	DUF3265 domain-containing protein	-
GPY55_RS18310	1774541..1774633	-	93	WP_005500330.1	DUF3265 domain-containing protein	-
GPY55_RS18315	1774654..1775322	-	669	WP_021704944.1	hypothetical protein	-
GPY55_RS18320	1775342..1775434	-	93	WP_180709821.1	DUF3265 domain-containing protein	-
GPY55_RS18325	1775449..1775931	-	483	WP_031847709.1	hypothetical protein	-
GPY55_RS18335	1776644..1777141	+	498	WP_083135878.1	hypothetical protein	-
GPY55_RS18340	1777157..1777249	-	93	WP_080254871.1	DUF3265 domain-containing protein	-
GPY55_RS18345	1777522..1777725	-	204	Protein_1699	hypothetical protein	-
GPY55_RS18350	1777775..1777843	-	69	WP_074531725.1	DUF3265 domain-containing protein	-
GPY55_RS18355	1777918..1778166	+	249	WP_005377003.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
GPY55_RS18360	1778156..1778446	+	291	WP_029853447.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GPY55_RS18365	1778465..1778605	-	141	WP_180776696.1	DUF3265 domain-containing protein	-
GPY55_RS18370	1778968..1779462	-	495	WP_031847825.1	GNAT family N-acetyltransferase	-
GPY55_RS18375	1779607..1780116	-	510	WP_005483274.1	ClbS/DfsB family four-helix bundle protein	-
GPY55_RS18380	1780261..1780605	-	345	WP_017449602.1	hypothetical protein	-
GPY55_RS18385	1780740..1781582	-	843	WP_180776697.1	fructose 1,6-bisphosphatase	-
GPY55_RS18390	1781707..1781831	-	125	Protein_1708	DUF3265 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integron	-	-	1671550..1825309	153759

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-83)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (12-75)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11242.20 Da
• Isoelectric Point: 10.5021

>T145027 WP_029853447.1 NZ_CP046831:1778156-1778446 [Vibrio parahaemolyticus]
MTYKLDFKKSALKEWKKLGSTLQQQFKKKLIERLDNPHVPASKLSGADNMYKIKLHQSGYRLVYKVEDDVIIVTVLAVGK
RERSDVYRKAMKRLDD

Nucleotide

• Length: 291 bp

>T145027 NZ_CP062250:c1265801-1265694 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9079.37 Da
• Isoelectric Point: 3.9610

>AT145027 WP_005377003.1 NZ_CP046831:1777918-1778166 [Vibrio parahaemolyticus]
MTTRILADVAASITELKANPMKVATSAYGEPVAVLNRNEPAFYCVPAEAYEMMMDRLEDLELLAIAKERESEESISVNID
DL

Nucleotide

• Length: 249 bp

>AT145027 NZ_CP062250:1265848-1265914 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Structures

Antitoxin

• AlphaFold DB: A0A347UR02