Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 1755138..1755676 Replicon chromosome
Accession NZ_CP046831
Organism Vibrio parahaemolyticus strain 2012AW-0224

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag GPY55_RS18110 Protein ID WP_031846693.1
Coordinates 1755377..1755676 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A0F2HR74
Locus tag GPY55_RS18105 Protein ID WP_011080384.1
Coordinates 1755138..1755380 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPY55_RS18055 1750304..1750960 - 657 WP_083135942.1 HAD-IA family hydrolase -
GPY55_RS18060 1750957..1751130 - 174 WP_140063127.1 DUF3265 domain-containing protein -
GPY55_RS18065 1751102..1751413 - 312 WP_031850888.1 antibiotic biosynthesis monooxygenase -
GPY55_RS18070 1751450..1751602 - 153 WP_078236020.1 DUF3265 domain-containing protein -
GPY55_RS18075 1751556..1752065 - 510 WP_025572811.1 hypothetical protein -
GPY55_RS18080 1752075..1752164 - 90 WP_080257806.1 DUF3265 domain-containing protein -
GPY55_RS18085 1752206..1752448 - 243 WP_031847232.1 hypothetical protein -
GPY55_RS18090 1752654..1753013 - 360 WP_139794907.1 hypothetical protein -
GPY55_RS18095 1753126..1754094 - 969 WP_083135183.1 hypothetical protein -
GPY55_RS18100 1754129..1754872 + 744 WP_158083975.1 hypothetical protein -
GPY55_RS18105 1755138..1755380 + 243 WP_011080384.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
GPY55_RS18110 1755377..1755676 + 300 WP_031846693.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GPY55_RS18115 1755815..1756453 - 639 WP_031846694.1 class I SAM-dependent methyltransferase -
GPY55_RS18120 1756582..1757268 - 687 WP_050548916.1 HAD family hydrolase -
GPY55_RS18125 1757387..1757863 - 477 WP_083135185.1 GNAT family N-acetyltransferase -
GPY55_RS18130 1757891..1757980 - 90 WP_072829136.1 DUF3265 domain-containing protein -
GPY55_RS18135 1757998..1758372 - 375 WP_047734438.1 nuclear transport factor 2 family protein -
GPY55_RS18150 1759607..1760110 - 504 WP_050549021.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - - 1671550..1825309 153759


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-78)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11689.36 Da        Isoelectric Point: 9.9572

>T145026 WP_031846693.1 NZ_CP046831:1755377-1755676 [Vibrio parahaemolyticus]
MRPFQLTNKAKSDLRDIALFTSRRWGREQRNIYLKQFDDSFWLLAENPDIGKACDEIRDGYRKFPQGSHVIFYRQIGSQN
IDIIRILHKSMDVNPIFGA

Download         Length: 300 bp

>T145026 NZ_CP062250:c1265266-1265159 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8953.88 Da        Isoelectric Point: 4.2213

>AT145026 WP_011080384.1 NZ_CP046831:1755138-1755380 [Vibrio parahaemolyticus]
MAKNTSITLGDHFDGFIANQIQSGRYGSASEVIRSALRLLETQETKMNTLRQLLVEGEESGVADYDLDSFINELDSEERK

Download         Length: 243 bp

>AT145026 NZ_CP062250:1265313-1265379 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0F2HR74

References