Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 1605782..1606341 Replicon chromosome
Accession NZ_CP046828
Organism Vibrio parahaemolyticus strain 2010V-1106

Toxin (Protein)


Gene name relE Uniprot ID A0A249W573
Locus tag GPY32_RS16975 Protein ID WP_005500338.1
Coordinates 1605782..1606060 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A347UR21
Locus tag GPY32_RS16980 Protein ID WP_005398409.1
Coordinates 1606057..1606341 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPY32_RS16915 1600852..1600944 + 93 WP_005500330.1 DUF3265 domain-containing protein -
GPY32_RS16920 1600970..1601407 + 438 WP_005500331.1 GIY-YIG nuclease family protein -
GPY32_RS16925 1602114..1602311 + 198 WP_005500332.1 hypothetical protein -
GPY32_RS16935 1602919..1602987 + 69 WP_079748735.1 DUF3265 domain-containing protein -
GPY32_RS16940 1603069..1603326 + 258 WP_005448240.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
GPY32_RS16945 1603314..1603616 + 303 WP_005500333.1 type II toxin-antitoxin system RelE/ParE family toxin -
GPY32_RS16950 1603655..1603744 + 90 WP_072828861.1 DUF3265 domain-containing protein -
GPY32_RS16955 1603792..1604160 + 369 WP_005500334.1 VOC family protein -
GPY32_RS16960 1604317..1605156 + 840 WP_005500335.1 hypothetical protein -
GPY32_RS16965 1605305..1605658 + 354 WP_005500336.1 glyoxalase/bleomycin resistance/dioxygenase family protein -
GPY32_RS25295 1605619..1605753 + 135 WP_161612893.1 DUF3265 domain-containing protein -
GPY32_RS16975 1605782..1606060 - 279 WP_005500338.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
GPY32_RS16980 1606057..1606341 - 285 WP_005398409.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
GPY32_RS16985 1606608..1606898 + 291 WP_005500341.1 YkgJ family cysteine cluster protein -
GPY32_RS16990 1607566..1608716 + 1151 WP_088337786.1 IS3 family transposase -
GPY32_RS16995 1608748..1609119 + 372 Protein_1467 pyridoxamine 5'-phosphate oxidase family protein -
GPY32_RS17000 1609487..1609933 - 447 WP_005500348.1 DUF3291 domain-containing protein -
GPY32_RS17005 1610275..1610736 + 462 WP_005500350.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1520228..1609933 89705
- inside Integron - - 1520752..1609252 88500


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10878.53 Da        Isoelectric Point: 4.2597

>T145024 WP_005500338.1 NZ_CP046828:c1606060-1605782 [Vibrio parahaemolyticus]
MILWEEESLDDREKIFEFLYDFNPDAAEKTDNLIEAKVENLLEQPLMGVQRDGIRGRLLIIPDISMIVSYWVEGDIIRVM
RVLHQKQKFPTD

Download         Length: 279 bp

>T145024 NZ_CP062250:c475764-475546 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 11069.40 Da        Isoelectric Point: 9.2167

>AT145024 WP_005398409.1 NZ_CP046828:c1606341-1606057 [Vibrio parahaemolyticus]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFVEHQTAKSR
MEERKARIRNRGKQ

Download         Length: 285 bp

>AT145024 NZ_CP062250:c476164-475790 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A249W573

Antitoxin

Source ID Structure
AlphaFold DB A0A347UR21

References