Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Phd(antitoxin)
Location 1603069..1603616 Replicon chromosome
Accession NZ_CP046828
Organism Vibrio parahaemolyticus strain 2010V-1106

Toxin (Protein)


Gene name relE Uniprot ID A0A249W5B6
Locus tag GPY32_RS16945 Protein ID WP_005500333.1
Coordinates 1603314..1603616 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID U3A269
Locus tag GPY32_RS16940 Protein ID WP_005448240.1
Coordinates 1603069..1603326 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPY32_RS16865 1598398..1598490 + 93 WP_193268598.1 DUF3265 domain-containing protein -
GPY32_RS16870 1598535..1598819 + 285 WP_005500325.1 nucleotide pyrophosphohydrolase -
GPY32_RS16875 1598827..1598937 + 111 WP_082798391.1 DUF3265 domain-containing protein -
GPY32_RS16880 1598964..1599236 + 273 WP_005462157.1 nicotinamide mononucleotide transporter -
GPY32_RS16885 1599268..1599357 + 90 WP_079748734.1 DUF3265 domain-containing protein -
GPY32_RS16890 1599388..1599684 + 297 WP_005500327.1 hypothetical protein -
GPY32_RS16895 1599624..1599791 + 168 WP_086027883.1 DUF3265 domain-containing protein -
GPY32_RS16900 1599821..1600201 + 381 WP_005487927.1 TonB family protein -
GPY32_RS16905 1600208..1600318 + 111 WP_079861117.1 DUF3265 domain-containing protein -
GPY32_RS16910 1600328..1600837 + 510 WP_005500328.1 hypothetical protein -
GPY32_RS16915 1600852..1600944 + 93 WP_005500330.1 DUF3265 domain-containing protein -
GPY32_RS16920 1600970..1601407 + 438 WP_005500331.1 GIY-YIG nuclease family protein -
GPY32_RS16925 1602114..1602311 + 198 WP_005500332.1 hypothetical protein -
GPY32_RS16935 1602919..1602987 + 69 WP_079748735.1 DUF3265 domain-containing protein -
GPY32_RS16940 1603069..1603326 + 258 WP_005448240.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GPY32_RS16945 1603314..1603616 + 303 WP_005500333.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GPY32_RS16950 1603655..1603744 + 90 WP_072828861.1 DUF3265 domain-containing protein -
GPY32_RS16955 1603792..1604160 + 369 WP_005500334.1 VOC family protein -
GPY32_RS16960 1604317..1605156 + 840 WP_005500335.1 hypothetical protein -
GPY32_RS16965 1605305..1605658 + 354 WP_005500336.1 glyoxalase/bleomycin resistance/dioxygenase family protein -
GPY32_RS25295 1605619..1605753 + 135 WP_161612893.1 DUF3265 domain-containing protein -
GPY32_RS16975 1605782..1606060 - 279 WP_005500338.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
GPY32_RS16980 1606057..1606341 - 285 WP_005398409.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
GPY32_RS16985 1606608..1606898 + 291 WP_005500341.1 YkgJ family cysteine cluster protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1520228..1609933 89705
- inside Integron - - 1520752..1609252 88500


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11682.65 Da        Isoelectric Point: 6.9806

>T145023 WP_005500333.1 NZ_CP046828:1603314-1603616 [Vibrio parahaemolyticus]
MAEIIWTEPALSDLNDIAEYIALENIVAAKQLVQTIFSKVERLQTFPKSGRIPPELEHLSYREVVVNPCRIFYKQDGDKV
FILFVMRAERDLRKFLLSKQ

Download         Length: 303 bp

>T145023 NZ_CP062250:c259380-259039 [Escherichia coli]
ATGAAAACTTTACCTGCAATAACTCAGCGGGCGGTGAAGCCCTGCCTGTCACCCGTGGCTGTCTGGCAAATGTTACTGAC
ACGTCTGCTGGAACAGCACTATGGTCTGACAATAAACGACACGCCATTCTGCAATGAGGCTGTGATTAAGGAACACATCG
ATGCCGGTATCACCCTAGCCGATGCCGTGAATTTTCTGGTAGAAAAATACGAGCTGGTTCGTATCGACAGGAAGGGATTT
AGCTGGCAGGAACAATCTCCTTATCTCCGGGCTGCAGACATTCTGCGAGCGCGGCAGGCAACTGGCTTGTTGCGGCAAAG
CCGTAACAACGTAGTACGATGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9606.10 Da        Isoelectric Point: 6.7269

>AT145023 WP_005448240.1 NZ_CP046828:1603069-1603326 [Vibrio parahaemolyticus]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLVDVDDYEFMQNRLAILEGIARGERALADGKVVSHDEAKDKM
SKWLK

Download         Length: 258 bp

>AT145023 NZ_CP062250:c259718-259401 [Escherichia coli]
ATGAGCAACCCTACCAGGGGCCTGCAGCGGGAGATTACACTGCGCCTGGGAGCCCGTCTGGTGCAGGAAGGCAACCGACT
GCATTATCTGGCTGACCGGGCCAGCATCACCGGCAAGTTCAGTGACATCGAATGCCGGAAGCTGGATGAAACATTCCCGC
ACTTTATCCTCCAGATGGAATCGATGCTGACCACCGGTGAACTCAGCCCCCACCATGCCCACTGCGTTACCCTGTACCAC
AACGATTTAACCTGCGAAGCCGACACCCTTGGCAGTTGCGGCTACGTATACATCGCCATTTACCCCACTCAGCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A249W5B6

Antitoxin

Source ID Structure
AlphaFold DB A0A432DGX8

References