Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 1541939..1542467 Replicon chromosome
Accession NZ_CP046828
Organism Vibrio parahaemolyticus strain 2010V-1106

Toxin (Protein)


Gene name relE Uniprot ID K5TRR0
Locus tag GPY32_RS16365 Protein ID WP_005377002.1
Coordinates 1541939..1542229 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A347UR02
Locus tag GPY32_RS16370 Protein ID WP_005377003.1
Coordinates 1542219..1542467 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPY32_RS16310 1537289..1537420 + 132 WP_005494795.1 DUF3265 domain-containing protein -
GPY32_RS16315 1538431..1538553 + 123 WP_079748760.1 DUF3265 domain-containing protein -
GPY32_RS16320 1538572..1539039 + 468 WP_005494803.1 GNAT family N-acetyltransferase -
GPY32_RS16325 1539039..1539167 + 129 WP_161612914.1 DUF3265 domain-containing protein -
GPY32_RS16330 1539530..1539622 + 93 WP_005494807.1 DUF3265 domain-containing protein -
GPY32_RS16335 1539724..1539933 + 210 WP_025506672.1 DUF3955 domain-containing protein -
GPY32_RS16345 1540607..1540696 + 90 WP_078235921.1 DUF3265 domain-containing protein -
GPY32_RS16350 1540730..1541182 + 453 WP_005494814.1 hypothetical protein -
GPY32_RS16355 1541218..1541310 + 93 WP_078535095.1 DUF3265 domain-containing protein -
GPY32_RS16360 1541831..1541920 + 90 WP_077680412.1 DUF3265 domain-containing protein -
GPY32_RS16365 1541939..1542229 - 291 WP_005377002.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GPY32_RS16370 1542219..1542467 - 249 WP_005377003.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GPY32_RS16375 1543215..1543619 + 405 WP_005494818.1 hypothetical protein -
GPY32_RS16380 1543634..1543726 + 93 WP_005494820.1 DUF3265 domain-containing protein -
GPY32_RS16390 1544216..1544347 + 132 WP_005494822.1 DUF3265 domain-containing protein -
GPY32_RS16395 1544391..1545014 + 624 WP_005494825.1 hypothetical protein -
GPY32_RS16400 1545639..1546160 + 522 WP_005494827.1 GNAT family N-acetyltransferase -
GPY32_RS16405 1546767..1547153 + 387 WP_021447429.1 NUDIX hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1520228..1609933 89705
- inside Integron - - 1520752..1609252 88500


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(12-75)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11261.25 Da        Isoelectric Point: 10.5932

>T145022 WP_005377002.1 NZ_CP046828:c1542229-1541939 [Vibrio parahaemolyticus]
MTYKLDFKKSALKEWKKLGSTLQQQFKKKLIERLDNPHVPASKLSGADNMYKIKLRQSGYRLVYKVEDDVIIVTVLAVGK
RERSDVYRKAMKRLDD

Download         Length: 291 bp

>T145022 NZ_CP062250:248788-249186 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCCTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGAGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGGGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9079.37 Da        Isoelectric Point: 3.9610

>AT145022 WP_005377003.1 NZ_CP046828:c1542467-1542219 [Vibrio parahaemolyticus]
MTTRILADVAASITELKANPMKVATSAYGEPVAVLNRNEPAFYCVPAEAYEMMMDRLEDLELLAIAKERESEESISVNID
DL

Download         Length: 249 bp

>AT145022 NZ_CP062250:248492-248785 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A347UR03

Antitoxin

Source ID Structure
AlphaFold DB A0A347UR02

References