Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 193655..195377 Replicon chromosome
Accession NZ_CP046823
Organism Vibrio mimicus strain 06-2455

Toxin (Protein)


Gene name mosT Uniprot ID A0A2J9V001
Locus tag GPY13_RS00965 Protein ID WP_000373552.1
Coordinates 194439..195377 (+) Length 313 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID A0A2J9V032
Locus tag GPY13_RS00960 Protein ID WP_005512037.1
Coordinates 193655..194446 (+) Length 264 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPY13_RS00935 188911..190355 + 1445 Protein_158 PTS N-acetylmuramic acid transporter subunit IIBC -
GPY13_RS00940 190497..190985 - 489 WP_000440283.1 TIGR00645 family protein -
GPY13_RS00945 191185..191409 - 225 WP_001147121.1 hypothetical protein -
GPY13_RS00950 191410..191694 - 285 WP_000623305.1 helix-turn-helix domain-containing protein -
GPY13_RS00955 191691..193385 - 1695 WP_001054573.1 DUF927 domain-containing protein -
GPY13_RS00960 193655..194446 + 792 WP_005512037.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
GPY13_RS00965 194439..195377 + 939 WP_000373552.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
GPY13_RS00970 195416..197557 + 2142 WP_000088945.1 site-specific DNA-methyltransferase -
GPY13_RS00975 197560..200160 + 2601 WP_000673263.1 DEAD/DEAH box helicase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 191410..206155 14745


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(13-278)

Antitoxin

Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system

(99-250)


Sequences

Toxin        


Download         Length: 313 a.a.        Molecular weight: 35431.56 Da        Isoelectric Point: 4.7722

>T145015 WP_000373552.1 NZ_CP046823:194439-195377 [Vibrio mimicus]
MDRESPYYKQVSLLIRMLPVVATEPSFALKGGTAINLFVRDFPRLSVDIDLAYLPLEPRNEALANVKAALQRITDLINKE
PENRAVLQDHRLDELRIVVTSPNATIKIEVSPVARGTLHKPDSLAVQESVEEEFGYAEIPVVSLPDLYGGKLCAAMDRQH
PRDLFDVRMLLAEEGISRDIFVGFITYVLSHPRPINEVMAPNWQPLDDKFQAEFDGMTFEPVELNDLISIRPAMVAALQA
HFTEKDRSFLLSFKQGDPDWSLFDYPDAAELPAIRWKLQNIAKLAKNQEKHREQLTKLESVLDDWLKQANSN

Download         Length: 939 bp

>T145015 NZ_CP062249:3271895-3272359 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAAACAGAAGAAACCCATTGA

Antitoxin


Download         Length: 264 a.a.        Molecular weight: 29962.15 Da        Isoelectric Point: 9.7821

>AT145015 WP_005512037.1 NZ_CP046823:193655-194446 [Vibrio mimicus]
MSSKINWLVANAYPGALVLQQWLTENGISYSLAQKYAQSGWLRKLSSGVYYRPSARDDVKPGWVDALQAMDTQLHHRVHL
AGLSSLTHQGLSHYLQLSKEQVWIGVKNKQSLPKWFREFPKQNWFYCGNHKLEAVSEKDLKVITVKGKELKASCPELAAY
EVVDAIGKQISFEHAAELFQGLVNLSPRKVQSLLERSSSVQTNRVFLFLSHYHGHQWTQRIDETKIALGSGKRQVVEQGR
FDERYQITVPEILSVKKEEANNG

Download         Length: 792 bp

>AT145015 NZ_CP062249:3271560-3271895 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J9V001

Antitoxin

Source ID Structure
AlphaFold DB A0A2J9V032

References