Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1030490..1032318 Replicon chromosome
Accession NZ_CP046822
Organism Vibrio metschnikovii strain 07-2421

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag GPX85_RS08450 Protein ID WP_158138014.1
Coordinates 1030957..1032318 (-) Length 454 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag GPX85_RS08445 Protein ID WP_158138012.1
Coordinates 1030490..1030972 (-) Length 161 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPX85_RS08420 1026646..1027635 + 990 WP_158138006.1 sulfate ABC transporter substrate-binding protein -
GPX85_RS08425 1027740..1028087 - 348 WP_154168894.1 carboxymuconolactone decarboxylase family protein -
GPX85_RS08430 1028237..1029031 + 795 WP_158138008.1 MetQ/NlpA family ABC transporter substrate-binding protein -
GPX85_RS08435 1029196..1029642 - 447 WP_158138010.1 redox-sensitive transcriptional activator SoxR -
GPX85_RS08440 1029758..1030168 + 411 WP_004395791.1 VOC family protein -
GPX85_RS08445 1030490..1030972 - 483 WP_158138012.1 helix-turn-helix domain-containing protein Antitoxin
GPX85_RS08450 1030957..1032318 - 1362 WP_158138014.1 type II toxin-antitoxin system HipA family toxin Toxin
GPX85_RS08455 1032554..1033002 - 449 Protein_838 integrase arm-type DNA-binding domain-containing protein -
GPX85_RS08465 1033604..1034089 - 486 WP_004395790.1 SsrA-binding protein SmpB -
GPX85_RS08470 1034370..1034804 + 435 WP_004395789.1 ubiquinone-binding protein -
GPX85_RS08475 1034801..1035124 + 324 WP_040904612.1 RnfH family protein -
GPX85_RS08480 1035264..1035623 - 360 WP_040904610.1 outer membrane protein assembly factor BamE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(166-385)

Antitoxin

Cro/C1-type helix-turn-helix domain

(88-139)


Sequences

Toxin        


Download         Length: 454 a.a.        Molecular weight: 51476.38 Da        Isoelectric Point: 5.0619

>T145014 WP_158138014.1 NZ_CP046822:c1032318-1030957 [Vibrio metschnikovii]
MEEITVQAFIKDEWIDIGIISFPKSSQHNFRVTELNYLSDYALEHHDKDDFHAVSLNHPVSFFFDDMSKPGWLKFLDDIM
PSGASRRYWVKHLDIEDLSSDEQDYVLLKFGTMSPIGNLRIKDSLPERYEVADNLYFSVDDVKNRAGDFLDYAQQRGAAA
GGATGAGGEAPKLILRCGFDHGSGSEKIWIDPYQDDNSNHDLHYLVKYPRGSRSTIDCNILRAEFYFYHELTEMGVETIA
TEGMRLEEGLNYPSLWLPRFDVQIINQQIKRFGMESVYSILKKGAGVTLDHETTIRTLIEKITESHMVKHQGYRFDTQAF
VIEWVKRDLLNILFGNSDNHGRNTSFLKGDGVIKLAPVYDFAPMKADPEGIPRTTKWKAPLEVGGTYDFVGIADTLSDLV
PKEVLLQELEVTASKCIDLKQRLALRGVPEQILEMPAVGLNHISEKLTKWGLL

Download         Length: 1362 bp

>T145014 NZ_CP062249:c3229013-3228699 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin


Download         Length: 161 a.a.        Molecular weight: 17520.00 Da        Isoelectric Point: 10.8975

>AT145014 WP_158138012.1 NZ_CP046822:c1030972-1030490 [Vibrio metschnikovii]
MGATMNKPSNKESVQDTVARLRANRNQHQPNTGTNATHSTKERSQLNTPTRSKTSKNAKAVSAAERKTEANKIIKHLLLG
ELTQGQALKSLRINILGLKQDVFARLVDVSRKTLSDIENDRGSYNTEILNKVFKPFGLKVGMLPSSPDVLKSLLIDGEAG

Download         Length: 483 bp

>AT145014 NZ_CP062249:c3228702-3228286 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References