Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-YefM |
| Location | 816856..817406 | Replicon | chromosome |
| Accession | NZ_CP046821 | ||
| Organism | Vibrio metschnikovii strain 07-2421 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | - |
| Locus tag | GPX85_RS03840 | Protein ID | WP_154170982.1 |
| Coordinates | 817107..817406 (+) | Length | 100 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | A0A0F2GMH9 |
| Locus tag | GPX85_RS03835 | Protein ID | WP_045572526.1 |
| Coordinates | 816856..817098 (+) | Length | 81 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GPX85_RS03800 | 811944..812489 | - | 546 | WP_158137401.1 | GNAT family N-acetyltransferase | - |
| GPX85_RS03805 | 812518..812628 | - | 111 | WP_081480741.1 | DUF3265 domain-containing protein | - |
| GPX85_RS03810 | 813207..813320 | - | 114 | WP_158137402.1 | DUF3265 domain-containing protein | - |
| GPX85_RS03815 | 813314..813784 | - | 471 | WP_158137403.1 | GNAT family N-acetyltransferase | - |
| GPX85_RS03820 | 814606..815121 | - | 516 | WP_158137404.1 | peptide deformylase | - |
| GPX85_RS03825 | 815289..815837 | - | 549 | WP_186464060.1 | hypothetical protein | - |
| GPX85_RS03830 | 816009..816605 | - | 597 | WP_154170995.1 | glutathione S-transferase family protein | - |
| GPX85_RS03835 | 816856..817098 | + | 243 | WP_045572526.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| GPX85_RS03840 | 817107..817406 | + | 300 | WP_154170982.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| GPX85_RS03845 | 817441..817584 | - | 144 | WP_199249650.1 | DUF3265 domain-containing protein | - |
| GPX85_RS03850 | 817559..818098 | - | 540 | WP_158137405.1 | hypothetical protein | - |
| GPX85_RS03855 | 818088..818246 | - | 159 | WP_199249689.1 | DUF3265 domain-containing protein | - |
| GPX85_RS03860 | 819322..819435 | - | 114 | WP_158137457.1 | DUF3265 domain-containing protein | - |
| GPX85_RS03865 | 819441..819983 | - | 543 | WP_158137407.1 | yfeABCD locus regulator | - |
| GPX85_RS03870 | 820132..820761 | - | 630 | WP_158137408.1 | FMN-binding negative transcriptional regulator | - |
| GPX85_RS03875 | 820779..820916 | - | 138 | WP_158137458.1 | DUF3265 domain-containing protein | - |
| GPX85_RS03880 | 820920..821261 | - | 342 | WP_158137409.1 | hypothetical protein | - |
| GPX85_RS03885 | 821874..821990 | - | 117 | WP_158137410.1 | DUF3265 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 725772..821261 | 95489 | |
| - | inside | Integron | - | katB / cqsA | 3..822451 | 822448 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 100 a.a. Molecular weight: 11622.31 Da Isoelectric Point: 9.8452
>T145013 WP_154170982.1 NZ_CP046821:817107-817406 [Vibrio metschnikovii]
MHSKQYKLSSLAQTHLRKVKNYTINNFSELQWQRYKETLLSGFQMLADNPDLGRSCHEIYNNGFYFPIGKHTAYFTKEEN
FILIVAVLGQSQLPKNHLK
MHSKQYKLSSLAQTHLRKVKNYTINNFSELQWQRYKETLLSGFQMLADNPDLGRSCHEIYNNGFYFPIGKHTAYFTKEEN
FILIVAVLGQSQLPKNHLK
Download Length: 300 bp
>T145013 NZ_CP062249:c3163102-3162806 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA
Antitoxin
Download Length: 81 a.a. Molecular weight: 9110.42 Da Isoelectric Point: 6.2161
>AT145013 WP_045572526.1 NZ_CP046821:816856-817098 [Vibrio metschnikovii]
MHTLTANDAKRNFGELLLNAQRQPIKISKNSKDAVVVMSIHDYEELEMMKTEYLKHCFNAAKDDLAKGNVVDGKDFLNEL
MHTLTANDAKRNFGELLLNAQRQPIKISKNSKDAVVVMSIHDYEELEMMKTEYLKHCFNAAKDDLAKGNVVDGKDFLNEL
Download Length: 243 bp
>AT145013 NZ_CP062249:c3162804-3162409 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|