Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 807975..808515 Replicon chromosome
Accession NZ_CP046821
Organism Vibrio metschnikovii strain 07-2421

Toxin (Protein)


Gene name relE Uniprot ID A0A7Y3QIZ2
Locus tag GPX85_RS03760 Protein ID WP_039428600.1
Coordinates 808246..808515 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A1T4SKS5
Locus tag GPX85_RS03755 Protein ID WP_032480862.1
Coordinates 807975..808253 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPX85_RS03725 803867..804358 - 492 WP_158137394.1 HAD-IA family hydrolase -
GPX85_RS03730 804476..804931 - 456 WP_158137395.1 hypothetical protein -
GPX85_RS03735 804961..805071 - 111 WP_129533207.1 DUF3265 domain-containing protein -
GPX85_RS03740 805758..806384 - 627 WP_158137396.1 class I SAM-dependent methyltransferase -
GPX85_RS03745 807118..807228 - 111 WP_081480741.1 DUF3265 domain-containing protein -
GPX85_RS03750 807808..807918 - 111 WP_154171236.1 DUF3265 domain-containing protein -
GPX85_RS03755 807975..808253 + 279 WP_032480862.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
GPX85_RS03760 808246..808515 + 270 WP_039428600.1 type II toxin-antitoxin system YafQ family toxin Toxin
GPX85_RS03765 808543..808674 - 132 WP_158137455.1 DUF3265 domain-containing protein -
GPX85_RS03770 808707..808988 - 282 WP_199249686.1 hypothetical protein -
GPX85_RS03775 809154..809771 - 618 WP_158137398.1 outer membrane beta-barrel protein -
GPX85_RS03780 809834..809944 - 111 WP_158137453.1 DUF3265 domain-containing protein -
GPX85_RS03785 810524..810634 - 111 WP_129533207.1 DUF3265 domain-containing protein -
GPX85_RS03790 811213..811338 - 126 WP_158137399.1 DUF3265 domain-containing protein -
GPX85_RS03795 811320..811805 - 486 WP_199249648.1 GNAT family N-acetyltransferase -
GPX85_RS03800 811944..812489 - 546 WP_158137401.1 GNAT family N-acetyltransferase -
GPX85_RS03805 812518..812628 - 111 WP_081480741.1 DUF3265 domain-containing protein -
GPX85_RS03810 813207..813320 - 114 WP_158137402.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 725772..821261 95489
- inside Integron - katB / cqsA 3..822451 822448


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10250.91 Da        Isoelectric Point: 8.9357

>T145012 WP_039428600.1 NZ_CP046821:808246-808515 [Vibrio metschnikovii]
MYSLEYSTQFKKDFKKITKMPISDIIEVGNIISKLQRGEKLDPKNVDHPLTGGWVGFRDCHVKPDLVLIYRIFDGQLQLA
RIGSHSDLF

Download         Length: 270 bp

>T145012 NZ_CP062249:c3035381-3034974 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10053.51 Da        Isoelectric Point: 6.0643

>AT145012 WP_032480862.1 NZ_CP046821:807975-808253 [Vibrio metschnikovii]
MRTEMLSTRIDHDTKVAFTSICDEMGLSTSQAIKIFAKAVINHGGIPFDLRVPQPNETTISAMNELVQGHGHKAESVDAM
LTELTEGKVKNV

Download         Length: 279 bp

>AT145012 NZ_CP062249:c3035628-3035362 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7Y3QIZ2

Antitoxin

Source ID Structure
AlphaFold DB A0A1T4SKS5

References