Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 788560..789326 Replicon chromosome
Accession NZ_CP046821
Organism Vibrio metschnikovii strain 07-2421

Toxin (Protein)


Gene name - Uniprot ID A0A6G3L8F0
Locus tag GPX85_RS03625 Protein ID WP_010319335.1
Coordinates 788829..789326 (+) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID C9P137
Locus tag GPX85_RS03620 Protein ID WP_004394087.1
Coordinates 788560..788832 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPX85_RS03570 783948..784058 - 111 WP_158137451.1 DUF3265 domain-containing protein -
GPX85_RS03575 784132..784329 - 198 WP_154171045.1 DUF1289 domain-containing protein -
GPX85_RS03580 784530..785459 - 930 WP_158137384.1 hypothetical protein -
GPX85_RS03585 786131..786220 - 90 WP_154170981.1 hypothetical protein -
GPX85_RS03590 786257..786595 - 339 WP_158137385.1 hypothetical protein -
GPX85_RS03595 786640..786750 - 111 WP_094165685.1 DUF3265 domain-containing protein -
GPX85_RS03600 787265..787561 - 297 WP_099610012.1 antibiotic biosynthesis monooxygenase -
GPX85_RS03605 787739..788026 - 288 WP_010320326.1 type II toxin-antitoxin system RelE/ParE family toxin -
GPX85_RS03610 788016..788267 - 252 WP_001250181.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
GPX85_RS03615 788327..788437 - 111 WP_158137386.1 hypothetical protein -
GPX85_RS03620 788560..788832 + 273 WP_004394087.1 DUF1778 domain-containing protein Antitoxin
GPX85_RS03625 788829..789326 + 498 WP_010319335.1 GNAT family N-acetyltransferase Toxin
GPX85_RS03630 789358..789468 - 111 WP_158137446.1 DUF3265 domain-containing protein -
GPX85_RS03635 790501..791847 + 1347 WP_058799734.1 group II intron reverse transcriptase/maturase -
GPX85_RS03640 792032..792273 + 242 Protein_720 type II toxin-antitoxin system Phd/YefM family antitoxin -
GPX85_RS03645 792282..792581 + 300 WP_158137387.1 type II toxin-antitoxin system RelE/ParE family toxin -
GPX85_RS03650 792627..792737 - 111 WP_081480741.1 DUF3265 domain-containing protein -
GPX85_RS03655 793317..793427 - 111 WP_158137443.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 725772..821261 95489
- flank IS/Tn - - 794319..795281 962
- inside Integron - katB / cqsA 3..822451 822448


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18577.41 Da        Isoelectric Point: 9.5688

>T145011 WP_010319335.1 NZ_CP046821:788829-789326 [Vibrio metschnikovii]
MMKTVLLDKDKHDRNRFNCGIDALNNYLKVMASQQAKKDNTRTFVLEDENNTSLIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAIDERYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFKAFQDAENKLFITISDI
RASLG

Download         Length: 498 bp

>T145011 NZ_CP062249:c2905649-2905314 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9872.43 Da        Isoelectric Point: 9.7681

>AT145011 WP_004394087.1 NZ_CP046821:788560-788832 [Vibrio metschnikovii]
MATTLPRITARVDVDTQNLLTKAAALAGMSSINSFVLNAAIEKAKQVIEREQTLKLSQADAILLMEALDKPTTLNQKLKT
AAERYETKNQ

Download         Length: 273 bp

>AT145011 NZ_CP062249:c2905897-2905649 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6G3L8F0

Antitoxin

Source ID Structure
AlphaFold DB A0A1T4SI33

References