Detailed information of TA system TA145009

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-YefM
• Location: 780522..781072
• Replicon: chromosome
• Accession: NZ_CP046821
• Organism: Vibrio metschnikovii strain 07-2421

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: GPX85_RS03545
• Protein ID: WP_158137380.1
• Coordinates: 780773..781072 (+)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: GPX85_RS03540
• Protein ID: WP_158137379.1
• Coordinates: 780522..780764 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GPX85_RS03505	776930..777217	-	288	WP_154171014.1	hypothetical protein	-
GPX85_RS03510	777445..777918	-	474	WP_158137378.1	GNAT family N-acetyltransferase	-
GPX85_RS03515	778068..778457	-	390	WP_158137450.1	DUF1090 domain-containing protein	-
GPX85_RS03520	778802..779032	+	231	WP_004397275.1	PAS factor family protein	-
GPX85_RS03525	779213..779584	-	372	Protein_698	MmcQ/YjbR family DNA-binding protein	-
GPX85_RS03530	779626..779736	-	111	WP_081480741.1	DUF3265 domain-containing protein	-
GPX85_RS03540	780522..780764	+	243	WP_158137379.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
GPX85_RS03545	780773..781072	+	300	WP_158137380.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GPX85_RS03550	781226..781660	-	435	WP_158137381.1	hypothetical protein	-
GPX85_RS03555	781712..781822	-	111	WP_094165685.1	DUF3265 domain-containing protein	-
GPX85_RS03560	781870..782565	-	696	WP_158137382.1	serine protease	-
GPX85_RS03565	782690..783358	-	669	WP_158137383.1	HAD family hydrolase	-
GPX85_RS03570	783948..784058	-	111	WP_158137451.1	DUF3265 domain-containing protein	-
GPX85_RS03575	784132..784329	-	198	WP_154171045.1	DUF1289 domain-containing protein	-
GPX85_RS03580	784530..785459	-	930	WP_158137384.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	725772..821261	95489
	-	inside	Integron	-	katB / cqsA	3..822451	822448

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-93)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-67)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11650.28 Da
• Isoelectric Point: 9.6595

>T145009 WP_158137380.1 NZ_CP046821:780773-781072 [Vibrio metschnikovii]
MHNKQYRLSSLAQTHLRKVKNYTINNFSELQWQRYKETLLSGFQMLADNPDLGRSCHEIYSNGFYFPIGKHTAYFTKEEN
FILIVAVLGQSQLPQNHLK

Nucleotide

• Length: 300 bp

>T145009 NZ_CP062249:2760476-2761549 [Escherichia coli]
ATGACAATCAGGAGTTACAAAAACTTAAATCTGGTCAGGGCAAATATCGAGACTGAATCCAGACAATTCATTGAAAATAA
AAACTATTCAATCCAATCAATTGGTCCTATGCCAGGGTCAAGGGCTGGGCTTCGGGTCGTATTTACCAGACCAGGGGTTA
ACTTGGCAACTGTGGACATTTTTTATAACGGGGACGGTTCGACTACAATTCAATATCTCACTGGAGCCAATCGTTCTCTG
GGCCAAGAGTTAGCGGATCATCTTTTTGAAACCATCAATCCTGCTGAATTTGAGCAGGTAAATATGGTACTGCAAGGATT
TGTAGAGACAAGCGTTCTACCTGTACTTGAGCTATCAGCAGATGAATCGCATATAGAGTTCAGAGAACACTCTCGTAACG
CTCATACCGTAGTGTGGAAAATTATTTCCACCAGCTATCAGGACGAATTGACTGTGAGCCTGCATATCACAACAGGTAAG
CTCCAGATTCAGGGCCGACCGCTGTCATGTTACAGAGTTTTCACGTTTAACTTGGCAGCCCTGCTTGATTTACAGGGTTT
GGAGAAAGTGCTAATCCGCCAGGAGGATGGTAAAGCTAATATTGTTCAACAGGAGGTTGCCCGCACTTACTTGCAGACTG
TAATGGCCGATGCTTACCCGCATCTCCACGTGACTGCCGAAAAATTGCTCGTTTCAGGGCTATGTGTTAAACTCGCCGCC
CCTGATTTGCCTGACTACTGTATGTTACTTTATCCTGAACTACGCACCATTGAAGGTGTCTTAAAAAGTAAGATGAGTGG
GTTAGGCATGCCAGTACAGCAGCCGGCAGGTTTTGGAACTTACTTTGATAAACCTGCTGCTCATTACATTCTGAAACCGC
AATTTGCAGCTACTCTTAGACCGGAACAGATTAACATCATCAGCACAGCCTATACTTTTTTTAATGTGGAACGTCATTCT
CTGTTCCACATGGAAACTGTGGTCGATGCCAGCCGTATGATTTCTGATATGGCCCGGTTGATGGGTAAAGCCACTAGAGC
GTGGGGAATAATCAAGGACTTATATATTGTTTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9124.45 Da
• Isoelectric Point: 6.2161

>AT145009 WP_158137379.1 NZ_CP046821:780522-780764 [Vibrio metschnikovii]
MHTLTANDAKRNFGELLLNAQRQPIKISKNSKDAVVVMSIHDYEELEMMKTEYLKHCFNAAKDDLAKGNVIDGKDFLNEL

Nucleotide

• Length: 243 bp

>AT145009 NZ_CP062249:2761542-2761913 [Escherichia coli]
TTGTTTGAAATCACCGGAATTAACGTCTCAGGGGCTCTAAAAGCTGTCGTTATGGCGACCGGCTTCGAGAACCCTTTGTC
CTCAGTTAATGAAATTGAGACGAAACTTTCTGCCCTACTGGGTAGTGAGACCACTGGTGAAATCCTTTTTGACCTCTTGT
GCGCTAACGGTCCAGAGTGGAACCGCTTCGTTACGCTGGAAATGAAATATGGCCGGATCATGCTGGATACGGCCAAAATT
ATTGATGAGCAGGACGTTCCGACACATATCCTGAGCAAACTGACTTTTACTTTACGTAATCATCCTGAGTACCTAGAAGC
CTCTGTTTTGTCTCCCGATGATGTACGCCAAGTCCTGTCAATGGATTTTTGA