Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc(toxin)
Location 737495..738066 Replicon chromosome
Accession NZ_CP046821
Organism Vibrio metschnikovii strain 07-2421

Toxin (Protein)


Gene name doc Uniprot ID A0A1T4SJW3
Locus tag GPX85_RS03240 Protein ID WP_000351249.1
Coordinates 737495..737896 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID Q8GNG3
Locus tag GPX85_RS17310 Protein ID WP_001080654.1
Coordinates 737896..738066 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPX85_RS03220 733239..733430 - 192 WP_158137353.1 DUF3265 domain-containing protein -
GPX85_RS03225 733877..735223 + 1347 WP_158137016.1 group II intron reverse transcriptase/maturase -
GPX85_RS03230 736000..736701 - 702 WP_158137354.1 hypothetical protein -
GPX85_RS03235 736836..737300 - 465 WP_158137355.1 hypothetical protein -
GPX85_RS03240 737495..737896 - 402 WP_000351249.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
GPX85_RS17310 737896..738066 - 171 WP_001080654.1 hypothetical protein Antitoxin
GPX85_RS17315 738137..738250 - 114 WP_154171240.1 DUF3265 domain-containing protein -
GPX85_RS03250 738450..739412 + 963 WP_158137349.1 IS110 family transposase -
GPX85_RS03255 739428..740012 - 585 WP_199249640.1 hypothetical protein -
GPX85_RS03260 740822..741286 - 465 WP_032480879.1 hypothetical protein -
GPX85_RS03265 741315..741425 - 111 WP_154171242.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 725772..821261 95489
- inside Integron - katB / cqsA 3..822451 822448
- inside Integron - - 735880..767489 31609


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(1-131)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14636.77 Da        Isoelectric Point: 4.0128

>T145006 WP_000351249.1 NZ_CP046821:c737896-737495 [Vibrio metschnikovii]
MDIICFPFERVIEINAFILKTEPGMKGAVDIPKLQGALGRIDNAIVYEGLDDVFEIAAKYTACIAVSHALPDANKRTGLA
VALEYLSLNDFELTQENDLLADAVRDLVIGIINETDFADILYAQYAKEQNSVL

Download         Length: 402 bp

>T145006 NZ_CP062249:2072249-2072623 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6287.35 Da        Isoelectric Point: 10.7274

>AT145006 WP_001080654.1 NZ_CP046821:c738066-737896 [Vibrio metschnikovii]
MNRKVEAYGVDAVERPKIKASKKLDLTGDAGRQIVKSETKLALRTHQKTFTKLADM

Download         Length: 171 bp

>AT145006 NZ_CP062249:2071792-2072160 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGATTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1T4SJW3

Antitoxin

Source ID Structure
AlphaFold DB A0A1T4SJJ1

References