Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 4828..5594 Replicon chromosome
Accession NZ_CP046821
Organism Vibrio metschnikovii strain 07-2421

Toxin (Protein)


Gene name - Uniprot ID A0A6G3L8F0
Locus tag GPX85_RS00055 Protein ID WP_010319335.1
Coordinates 5097..5594 (+) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID C9P137
Locus tag GPX85_RS00050 Protein ID WP_004394087.1
Coordinates 4828..5100 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPX85_RS00010 369..482 - 114 WP_102787215.1 DUF3265 domain-containing protein -
GPX85_RS00015 486..1688 - 1203 WP_158137012.1 DUF3644 domain-containing protein -
GPX85_RS00020 1724..1846 - 123 WP_158137013.1 DUF3265 domain-containing protein -
GPX85_RS00025 1831..2316 - 486 WP_158137014.1 GNAT family N-acetyltransferase -
GPX85_RS00030 2345..2479 - 135 WP_174223872.1 DUF3265 domain-containing protein -
GPX85_RS00035 2460..3230 - 771 WP_158137015.1 GNAT family N-acetyltransferase -
GPX85_RS00040 3266..3382 - 117 WP_158137410.1 DUF3265 domain-containing protein -
GPX85_RS00045 3951..4619 + 669 WP_154171029.1 methyltransferase domain-containing protein -
GPX85_RS00050 4828..5100 + 273 WP_004394087.1 DUF1778 domain-containing protein Antitoxin
GPX85_RS00055 5097..5594 + 498 WP_010319335.1 GNAT family N-acetyltransferase Toxin
GPX85_RS00060 5818..6048 + 231 WP_154171038.1 PAS factor family protein -
GPX85_RS00065 6760..8106 + 1347 WP_158137016.1 group II intron reverse transcriptase/maturase -
GPX85_RS00070 8192..9124 - 933 WP_158137017.1 DUF2971 domain-containing protein -
GPX85_RS00075 9168..9278 - 111 WP_154171236.1 DUF3265 domain-containing protein -
GPX85_RS00080 9791..10144 - 354 WP_154170958.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - katB / cqsA 3..822451 822448


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18577.41 Da        Isoelectric Point: 9.5688

>T145004 WP_010319335.1 NZ_CP046821:5097-5594 [Vibrio metschnikovii]
MMKTVLLDKDKHDRNRFNCGIDALNNYLKVMASQQAKKDNTRTFVLEDENNTSLIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAIDERYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFKAFQDAENKLFITISDI
RASLG

Download         Length: 498 bp

>T145004 NZ_CP062249:c1641089-1640802 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9872.43 Da        Isoelectric Point: 9.7681

>AT145004 WP_004394087.1 NZ_CP046821:4828-5100 [Vibrio metschnikovii]
MATTLPRITARVDVDTQNLLTKAAALAGMSSINSFVLNAAIEKAKQVIEREQTLKLSQADAILLMEALDKPTTLNQKLKT
AAERYETKNQ

Download         Length: 273 bp

>AT145004 NZ_CP062249:c1641328-1641089 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6G3L8F0

Antitoxin

Source ID Structure
AlphaFold DB A0A1T4SI33

References