Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/PRK09812-MazE
Location 993135..993729 Replicon chromosome
Accession NZ_CP046819
Organism Vibrio metoecus strain 2011V-1015

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag GPY06_RS04955 Protein ID WP_032479234.1
Coordinates 993135..993476 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag GPY06_RS04960 Protein ID WP_032479235.1
Coordinates 993469..993729 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPY06_RS04925 989590..989952 + 363 WP_032479229.1 hypothetical protein -
GPY06_RS04930 989993..990334 + 342 WP_158119436.1 hypothetical protein -
GPY06_RS04935 990334..990984 + 651 WP_158119307.1 hypothetical protein -
GPY06_RS04940 990988..991365 + 378 WP_148527921.1 hypothetical protein -
GPY06_RS04945 991368..991628 + 261 WP_032479232.1 hypothetical protein -
GPY06_RS04950 991628..993106 + 1479 WP_158119308.1 ATPase -
GPY06_RS04955 993135..993476 - 342 WP_032479234.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
GPY06_RS04960 993469..993729 - 261 WP_032479235.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 952267..1021366 69099


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-111)

Antitoxin

SpoVT-AbrB domain

(8-50)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12339.97 Da        Isoelectric Point: 4.5928

>T145003 WP_032479234.1 NZ_CP046819:c993476-993135 [Vibrio metoecus]
MGKYAFHQASIVHLDFDPQAGREMSGPHFALVISNDEFNESEMAMVCPITQGTYHREGGFTTSLMGTGTTTQGVVVANAA
QILDMKARNARFVEYVDSDTLEIVIAKVQAIIE

Download         Length: 342 bp

>T145003 NZ_CP062249:c1587632-1586310 [Escherichia coli]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCAAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CTGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCCAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTGACGTTAATACCCGAAGA
CGAAACCGTAACGCATCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGACTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCGCTAGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCACAGGAGAAGACAGCACTG
CTCAGAATAGGCAATGACTGGTGCATTCCGAAAGGAATAACGCCGACGACGCACATCATTAAATTACCGATTGGCGAAAT
CAGGCAGCCCAATGCGACGCTCGATCTCAGCCAAAGCGTTGATAATGAGTATTACTGTCTGCTGCTGGCGAAAGAACTTG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAATGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATGCTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGTCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCAGGCATCGCGCGGATCATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAATTCCAGGTCTTCCAGTGGTTGATTGGCGCAACGGACGGTCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTTTGGCGACAGCAAAGGTGCTGAGATTCCCGGAAGTGCAGATGCATGAAATCCTGAGTGACTTTGCCAGAATGATTCCA
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAAGCAATGTGTT
GAGGTTGCATGGACGGTTAAGCCGAGAATACGGTAGTAAGTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9562.05 Da        Isoelectric Point: 10.0983

>AT145003 WP_032479235.1 NZ_CP046819:c993729-993469 [Vibrio metoecus]
MQKTLTSVGNSTALTLPQAYLQQLGLHKGSKVNIALIEGKITIEPVKAKPRFTIKELMANTDFDAMREDKELQAWQNKPS
VGREHG

Download         Length: 261 bp

>AT145003 NZ_CP062249:c1587898-1587632 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTGGCGAATGCAATGAAACTGGTTCGCCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATTGGTATTAAGCAGGCGACGATTTCCAATTTCGAAAACAACCCTGACAATACCACGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACGCTATGCGACGCGAAAAATGCCTCGCCAGAATCA
ACAGAACAGCAAAATCTGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References