Detailed information of TA system TA145001

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 110099..110627
• Replicon: chromosome
• Accession: NZ_CP046819
• Organism: Vibrio metoecus strain 2011V-1015

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: GPY06_RS00775
• Protein ID: WP_113604414.1
• Coordinates: 110337..110627 (+)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: H9L4T4
• Locus tag: GPY06_RS00770
• Protein ID: WP_000213183.1
• Coordinates: 110099..110347 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GPY06_RS00725	105107..105574	-	468	WP_001289288.1	OsmC family protein	-
GPY06_RS00730	105786..105956	-	171	WP_158119396.1	DUF645 family protein	-
GPY06_RS00740	106268..106708	-	441	WP_158118931.1	hypothetical protein	-
GPY06_RS00745	106876..107403	-	528	WP_158118932.1	phosphoglycerate mutase family protein	-
GPY06_RS19265	107617..107712	-	96	WP_001907607.1	DUF645 family protein	-
GPY06_RS00755	108065..108427	-	363	WP_046028246.1	hypothetical protein	-
GPY06_RS00760	108565..109338	-	774	WP_158118933.1	NERD domain-containing protein	-
GPY06_RS00765	109488..109883	-	396	WP_158118934.1	hypothetical protein	-
GPY06_RS00770	110099..110347	+	249	WP_000213183.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
GPY06_RS00775	110337..110627	+	291	WP_113604414.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GPY06_RS00780	110755..111189	-	435	WP_158118935.1	GNAT family N-acetyltransferase	-
GPY06_RS19410	111221..111313	-	93	WP_202982015.1	DUF3265 domain-containing protein	-
GPY06_RS00790	111389..111619	-	231	WP_158118937.1	hypothetical protein	-
GPY06_RS00795	111621..112856	-	1236	WP_158118938.1	hypothetical protein	-
GPY06_RS00805	113561..113743	-	183	WP_094392974.1	DUF645 family protein	-
GPY06_RS00820	114149..114430	-	282	WP_158118939.1	DUF1289 domain-containing protein	-
GPY06_RS00825	114379..114492	-	114	WP_158118940.1	acetyltransferase	-
GPY06_RS00830	114607..114786	-	180	WP_158118941.1	DUF645 family protein	-
GPY06_RS00840	115059..115241	-	183	Protein_155	DUF645 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integron	-	-	51554..166505	114951

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-86)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11231.23 Da
• Isoelectric Point: 10.4678

>T145001 WP_113604414.1 NZ_CP046819:110337-110627 [Vibrio metoecus]
MTYKLEFKKSALKEWKKLAVPLQQQFKKKLIERLENPHVPAAKLSGAENIYKIKLRQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD

Nucleotide

• Length: 291 bp

>T145001 NZ_CP062249:c1409383-1409189 [Escherichia coli]
ATGAGATATGACAATGTTAAACCATGTCCATTTTGTGGTTGTCCATCAGTAACGGTGAAAGCCATTTCAGGATATTACCG
AGCGAAGTGTAACGGATGCGAATCCCGAACCGGTTATGGTGGAAGTGAAAAAGAAGCACTCGAAAGATGGAATAAACGAA
CCACTGGAAATAATAATGGAGGTGTTCATGTATAA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 8937.28 Da
• Isoelectric Point: 4.1079

>AT145001 WP_000213183.1 NZ_CP046819:110099-110347 [Vibrio metoecus]
MTTRILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPASTYEIMMDKLEDLELLAIAKERLSEDSVSVNID
DL

Nucleotide

• Length: 249 bp

>AT145001 NZ_CP062249:1409012-1409190 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Structures

Antitoxin

• AlphaFold DB: A0A366A3W8