Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 91638..92176 Replicon chromosome
Accession NZ_CP046819
Organism Vibrio metoecus strain 2011V-1015

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag GPY06_RS00575 Protein ID WP_158118927.1
Coordinates 91877..92176 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A271VK51
Locus tag GPY06_RS00570 Protein ID WP_001107720.1
Coordinates 91638..91880 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPY06_RS00525 87299..87661 - 363 WP_046122431.1 DUF4144 domain-containing protein -
GPY06_RS00530 87761..88030 - 270 WP_158118922.1 hypothetical protein -
GPY06_RS00535 88095..88526 - 432 WP_158118923.1 hypothetical protein -
GPY06_RS00545 88724..88906 - 183 WP_158118925.1 DUF645 family protein -
GPY06_RS00550 89695..90057 - 363 WP_167517735.1 DUF4144 domain-containing protein -
GPY06_RS00555 90156..90551 - 396 WP_081020549.1 hypothetical protein -
GPY06_RS00570 91638..91880 + 243 WP_001107720.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
GPY06_RS00575 91877..92176 + 300 WP_158118927.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GPY06_RS00580 92314..92503 - 190 Protein_111 DUF645 family protein -
GPY06_RS00585 92787..93173 - 387 WP_000703159.1 VOC family protein -
GPY06_RS00590 93438..93674 + 237 WP_000772130.1 RNA-binding protein -
GPY06_RS00595 93850..94236 - 387 WP_001015088.1 MmcQ/YjbR family DNA-binding protein -
GPY06_RS00600 94494..94730 + 237 WP_000772130.1 RNA-binding protein -
GPY06_RS00605 94776..94847 - 72 Protein_116 acetyltransferase -
GPY06_RS00610 94963..95142 - 180 WP_158119393.1 DUF645 family protein -
GPY06_RS00620 95499..95670 - 172 Protein_118 DUF645 family protein -
GPY06_RS00635 96539..96898 - 360 WP_000609947.1 HNH endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - - 51554..166505 114951


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-79)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11531.25 Da        Isoelectric Point: 10.1783

>T145000 WP_158118927.1 NZ_CP046819:91877-92176 [Vibrio metoecus]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPGIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA

Download         Length: 300 bp

>T145000 NZ_CP062249:c1267000-1266893 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8950.82 Da        Isoelectric Point: 4.1677

>AT145000 WP_001107720.1 NZ_CP046819:91638-91880 [Vibrio metoecus]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLVEGEQSGDADYDLDSFINELDSENIR

Download         Length: 243 bp

>AT145000 NZ_CP062249:1267047-1267113 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A271VK51

References