Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 65713..66291 Replicon chromosome
Accession NZ_CP046819
Organism Vibrio metoecus strain 2011V-1015

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag GPY06_RS00340 Protein ID WP_167517731.1
Coordinates 65974..66291 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A366AI09
Locus tag GPY06_RS00335 Protein ID WP_000557291.1
Coordinates 65713..65955 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPY06_RS00305 61935..62237 - 303 WP_158118902.1 hypothetical protein -
GPY06_RS00310 62433..62549 - 117 WP_001985501.1 hypothetical protein -
GPY06_RS00315 62512..62639 - 128 Protein_62 DUF645 family protein -
GPY06_RS00320 62942..63502 - 561 WP_055034282.1 hypothetical protein -
GPY06_RS00325 63682..64905 - 1224 WP_158118903.1 DUF3883 domain-containing protein -
GPY06_RS00330 65144..65314 - 171 WP_158118904.1 DUF645 family protein -
GPY06_RS00335 65713..65955 + 243 WP_000557291.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GPY06_RS00340 65974..66291 + 318 WP_167517731.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GPY06_RS00345 66427..66894 - 468 WP_158118906.1 GNAT family N-acetyltransferase -
GPY06_RS00350 67048..67554 - 507 Protein_69 GNAT family N-acetyltransferase -
GPY06_RS00355 67691..68038 - 348 WP_158118907.1 hypothetical protein -
GPY06_RS00360 68194..68793 - 600 WP_158118908.1 pentapeptide repeat-containing protein -
GPY06_RS00365 68989..69155 - 167 Protein_72 DUF645 family protein -
GPY06_RS19395 69230..69391 - 162 Protein_73 acetyltransferase -
GPY06_RS00370 69447..69986 - 540 WP_142570755.1 hypothetical protein -
GPY06_RS00375 70124..70621 - 498 WP_055030562.1 DUF2867 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - - 51554..166505 114951


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12193.98 Da        Isoelectric Point: 9.5425

>T144999 WP_167517731.1 NZ_CP046819:65974-66291 [Vibrio metoecus]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAD
FILIVAVLGQSQLPQKHFKQSRFVS

Download         Length: 318 bp

>T144999 NZ_CP062249:c1266465-1266358 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8931.22 Da        Isoelectric Point: 5.6630

>AT144999 WP_000557291.1 NZ_CP046819:65713-65955 [Vibrio metoecus]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGAAFLNTL

Download         Length: 243 bp

>AT144999 NZ_CP062249:1266512-1266578 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A366AI09

References