Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 57793..58358 Replicon chromosome
Accession NZ_CP046819
Organism Vibrio metoecus strain 2011V-1015

Toxin (Protein)


Gene name relE Uniprot ID D7HCW8
Locus tag GPY06_RS00270 Protein ID WP_000869999.1
Coordinates 57793..58080 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D0IIK3
Locus tag GPY06_RS00275 Protein ID WP_000086649.1
Coordinates 58077..58358 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPY06_RS00230 53082..53540 - 459 Protein_45 hypothetical protein -
GPY06_RS00235 53691..53936 + 246 WP_001260801.1 type II toxin-antitoxin system CcdA family antitoxin -
GPY06_RS00240 53936..54253 + 318 WP_095474062.1 CcdB family protein -
GPY06_RS00245 54469..55428 + 960 WP_158118895.1 IS30 family transposase -
GPY06_RS00250 55755..56336 - 582 WP_158118896.1 hypothetical protein -
GPY06_RS00255 56544..56828 + 285 WP_019829633.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
GPY06_RS00260 56825..57103 + 279 WP_000578471.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
GPY06_RS00265 57302..57484 - 183 WP_158118897.1 DUF645 family protein -
GPY06_RS00270 57793..58080 - 288 WP_000869999.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GPY06_RS00275 58077..58358 - 282 WP_000086649.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GPY06_RS00280 58573..58962 - 390 WP_000491261.1 VOC family protein -
GPY06_RS00285 59177..59554 - 378 WP_158118899.1 hypothetical protein -
GPY06_RS00290 59718..60314 - 597 WP_158118900.1 hypothetical protein -
GPY06_RS00295 60567..60704 - 138 WP_158118901.1 DUF645 family protein -
GPY06_RS00305 61935..62237 - 303 WP_158118902.1 hypothetical protein -
GPY06_RS00310 62433..62549 - 117 WP_001985501.1 hypothetical protein -
GPY06_RS00315 62512..62639 - 128 Protein_62 DUF645 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - - 51554..166505 114951


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(9-74)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10997.74 Da        Isoelectric Point: 6.0710

>T144998 WP_000869999.1 NZ_CP046819:c58080-57793 [Vibrio metoecus]
MKVVWSPLALQKLGDAAEFIALDNPSAAEKWVNEVFDKTELLGSMPEMGRMVPEMPHTNYREIIFGHYRIIYSLSHEIRV
LTVRNCRQLLTEHDV

Download         Length: 288 bp

>T144998 NZ_CP062249:c1265930-1265823 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10361.93 Da        Isoelectric Point: 5.1548

>AT144998 WP_000086649.1 NZ_CP046819:c58358-58077 [Vibrio metoecus]
MSRIHLDQDIQPLSEFRAGVASFIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLAAGLGISN
EDARSQVLGRIIK

Download         Length: 282 bp

>AT144998 NZ_CP062249:1265978-1266044 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3AEF1

Antitoxin

Source ID Structure
AlphaFold DB A0A0K9UIW4

References