Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 56544..57103 Replicon chromosome
Accession NZ_CP046819
Organism Vibrio metoecus strain 2011V-1015

Toxin (Protein)


Gene name relE Uniprot ID D7HHK2
Locus tag GPY06_RS00260 Protein ID WP_000578471.1
Coordinates 56825..57103 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag GPY06_RS00255 Protein ID WP_019829633.1
Coordinates 56544..56828 (+) Length 95 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPY06_RS00225 51894..53071 + 1178 WP_165481032.1 IS3 family transposase -
GPY06_RS00230 53082..53540 - 459 Protein_45 hypothetical protein -
GPY06_RS00235 53691..53936 + 246 WP_001260801.1 type II toxin-antitoxin system CcdA family antitoxin -
GPY06_RS00240 53936..54253 + 318 WP_095474062.1 CcdB family protein -
GPY06_RS00245 54469..55428 + 960 WP_158118895.1 IS30 family transposase -
GPY06_RS00250 55755..56336 - 582 WP_158118896.1 hypothetical protein -
GPY06_RS00255 56544..56828 + 285 WP_019829633.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
GPY06_RS00260 56825..57103 + 279 WP_000578471.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
GPY06_RS00265 57302..57484 - 183 WP_158118897.1 DUF645 family protein -
GPY06_RS00270 57793..58080 - 288 WP_000869999.1 type II toxin-antitoxin system RelE/ParE family toxin -
GPY06_RS00275 58077..58358 - 282 WP_000086649.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
GPY06_RS00280 58573..58962 - 390 WP_000491261.1 VOC family protein -
GPY06_RS00285 59177..59554 - 378 WP_158118899.1 hypothetical protein -
GPY06_RS00290 59718..60314 - 597 WP_158118900.1 hypothetical protein -
GPY06_RS00295 60567..60704 - 138 WP_158118901.1 DUF645 family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - - 51554..166505 114951


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 93 a.a.        Molecular weight: 10838.56 Da        Isoelectric Point: 4.6794

>T144997 WP_000578471.1 NZ_CP046819:56825-57103 [Vibrio metoecus]
MIFWEEASLNDREKIFEFLYDFNPAAAEKTDELIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T144997 NZ_CP062249:c475764-475546 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10929.30 Da        Isoelectric Point: 8.0775

>AT144997 WP_019829633.1 NZ_CP046819:56544-56828 [Vibrio metoecus]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIVKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT144997 NZ_CP062249:c476164-475790 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A271VKS2


Antitoxin

Source ID Structure

References