Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 1127633..1128161 Replicon chromosome
Accession NZ_CP046818
Organism Vibrio metoecus strain 06-2478

Toxin (Protein)


Gene name relE Uniprot ID H9L4R3
Locus tag GPX95_RS18545 Protein ID WP_000221352.1
Coordinates 1127633..1127923 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID H9L4T4
Locus tag GPX95_RS18550 Protein ID WP_000213183.1
Coordinates 1127913..1128161 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPX95_RS18520 1122961..1123386 + 426 WP_032473260.1 hypothetical protein -
GPX95_RS18525 1123423..1124382 - 960 WP_000221450.1 IS30 family transposase -
GPX95_RS18530 1125047..1126261 + 1215 WP_055065356.1 hypothetical protein -
GPX95_RS18535 1126577..1126813 - 237 WP_055030896.1 RNA-binding protein -
GPX95_RS18540 1127051..1127506 + 456 WP_055030895.1 GNAT family N-acetyltransferase -
GPX95_RS18545 1127633..1127923 - 291 WP_000221352.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GPX95_RS18550 1127913..1128161 - 249 WP_000213183.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GPX95_RS18560 1128360..1128911 + 552 WP_055030894.1 VRR-NUC domain-containing protein -
GPX95_RS18565 1128934..1129248 - 315 Protein_1028 IS30 family transposase -
GPX95_RS18570 1129392..1130396 + 1005 WP_055030893.1 LD-carboxypeptidase -
GPX95_RS18575 1130485..1131024 + 540 WP_055030892.1 isochorismatase family protein -
GPX95_RS18580 1131083..1131262 - 180 WP_055030486.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1024742..1129239 104497
- inside Integron - - 1025906..1128911 103005


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11247.23 Da        Isoelectric Point: 10.4678

>T144996 WP_000221352.1 NZ_CP046818:c1127923-1127633 [Vibrio metoecus]
MTYKLEFKKSALKEWKKLAVPLQQQFKKKLIERLENPHVPSAKLSGAENIYKIKLRQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD

Download         Length: 291 bp

>T144996 NZ_CP062249:c259380-259039 [Escherichia coli]
ATGAAAACTTTACCTGCAATAACTCAGCGGGCGGTGAAGCCCTGCCTGTCACCCGTGGCTGTCTGGCAAATGTTACTGAC
ACGTCTGCTGGAACAGCACTATGGTCTGACAATAAACGACACGCCATTCTGCAATGAGGCTGTGATTAAGGAACACATCG
ATGCCGGTATCACCCTAGCCGATGCCGTGAATTTTCTGGTAGAAAAATACGAGCTGGTTCGTATCGACAGGAAGGGATTT
AGCTGGCAGGAACAATCTCCTTATCTCCGGGCTGCAGACATTCTGCGAGCGCGGCAGGCAACTGGCTTGTTGCGGCAAAG
CCGTAACAACGTAGTACGATGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8937.28 Da        Isoelectric Point: 4.1079

>AT144996 WP_000213183.1 NZ_CP046818:c1128161-1127913 [Vibrio metoecus]
MTTRILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPASTYEIMMDKLEDLELLAIAKERLSEDSVSVNID
DL

Download         Length: 249 bp

>AT144996 NZ_CP062249:c259718-259401 [Escherichia coli]
ATGAGCAACCCTACCAGGGGCCTGCAGCGGGAGATTACACTGCGCCTGGGAGCCCGTCTGGTGCAGGAAGGCAACCGACT
GCATTATCTGGCTGACCGGGCCAGCATCACCGGCAAGTTCAGTGACATCGAATGCCGGAAGCTGGATGAAACATTCCCGC
ACTTTATCCTCCAGATGGAATCGATGCTGACCACCGGTGAACTCAGCCCCCACCATGCCCACTGCGTTACCCTGTACCAC
AACGATTTAACCTGCGAAGCCGACACCCTTGGCAGTTGCGGCTACGTATACATCGCCATTTACCCCACTCAGCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB H9L4R3

Antitoxin

Source ID Structure
AlphaFold DB A0A366A3W8

References