Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 1088135..1088694 Replicon chromosome
Accession NZ_CP046818
Organism Vibrio metoecus strain 06-2478

Toxin (Protein)


Gene name relE Uniprot ID D7HHK2
Locus tag GPX95_RS18210 Protein ID WP_000578471.1
Coordinates 1088135..1088413 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag GPX95_RS18215 Protein ID WP_000381183.1
Coordinates 1088410..1088694 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPX95_RS18175 1083870..1085516 + 1647 WP_055032245.1 hypothetical protein -
GPX95_RS18180 1085488..1085628 + 141 WP_095457904.1 DUF3265 domain-containing protein -
GPX95_RS18185 1085703..1086116 + 414 WP_000049417.1 VOC family protein -
GPX95_RS18190 1086421..1086561 + 141 WP_187120777.1 DUF645 family protein -
GPX95_RS18195 1086808..1087272 + 465 WP_055032235.1 ASCH domain-containing protein -
GPX95_RS18200 1087429..1087998 + 570 WP_053034771.1 flavodoxin family protein -
GPX95_RS18210 1088135..1088413 - 279 WP_000578471.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
GPX95_RS18215 1088410..1088694 - 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
GPX95_RS18220 1088890..1089339 + 450 WP_001026802.1 GyrI-like domain-containing protein -
GPX95_RS18225 1089489..1089875 + 387 WP_055032234.1 hypothetical protein -
GPX95_RS18235 1090070..1090729 + 660 WP_158160348.1 SLATT domain-containing protein -
GPX95_RS18240 1090720..1091679 - 960 WP_000221450.1 IS30 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1024742..1129239 104497
- inside Integron - - 1025906..1128911 103005


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10838.56 Da        Isoelectric Point: 4.6794

>T144995 WP_000578471.1 NZ_CP046818:c1088413-1088135 [Vibrio metoecus]
MIFWEEASLNDREKIFEFLYDFNPAAAEKTDELIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T144995 NZ_CP062249:248788-249186 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCCTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGAGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGGGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT144995 WP_000381183.1 NZ_CP046818:c1088694-1088410 [Vibrio metoecus]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT144995 NZ_CP062249:248492-248785 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A271VKS2

Antitoxin

Source ID Structure
AlphaFold DB A0A067BL33

References