Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/YafN(antitoxin) |
| Location | 1071194..1071759 | Replicon | chromosome |
| Accession | NZ_CP046818 | ||
| Organism | Vibrio metoecus strain 06-2478 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | A0A0H2MSY5 |
| Locus tag | GPX95_RS18055 | Protein ID | WP_015296903.1 |
| Coordinates | 1071472..1071759 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | U3BLE1 |
| Locus tag | GPX95_RS18050 | Protein ID | WP_000086647.1 |
| Coordinates | 1071194..1071475 (+) | Length | 94 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GPX95_RS18005 | 1066336..1066518 | + | 183 | WP_055032196.1 | DUF645 family protein | - |
| GPX95_RS18010 | 1066698..1067339 | + | 642 | WP_055032190.1 | hypothetical protein | - |
| GPX95_RS18015 | 1067526..1067822 | - | 297 | WP_055032189.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| GPX95_RS18020 | 1067829..1068071 | - | 243 | WP_000557295.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| GPX95_RS18025 | 1068373..1068762 | + | 390 | WP_199250741.1 | VOC family protein | - |
| GPX95_RS18725 | 1068833..1068952 | + | 120 | WP_198926210.1 | acetyltransferase | - |
| GPX95_RS18030 | 1068929..1069438 | - | 510 | WP_055032250.1 | hypothetical protein | - |
| GPX95_RS18040 | 1069716..1069952 | - | 237 | WP_000772130.1 | RNA-binding protein | - |
| GPX95_RS18045 | 1070204..1070995 | + | 792 | WP_158160346.1 | hypothetical protein | - |
| GPX95_RS18050 | 1071194..1071475 | + | 282 | WP_000086647.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| GPX95_RS18055 | 1071472..1071759 | + | 288 | WP_015296903.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| GPX95_RS18730 | 1071787..1071879 | + | 93 | WP_079767280.1 | DUF3265 domain-containing protein | - |
| GPX95_RS18060 | 1071906..1072823 | + | 918 | WP_055032217.1 | hypothetical protein | - |
| GPX95_RS18065 | 1072817..1072930 | + | 114 | Protein_942 | DUF3265 domain-containing protein | - |
| GPX95_RS18070 | 1073005..1073418 | + | 414 | WP_055032216.1 | VOC family protein | - |
| GPX95_RS18080 | 1073728..1073907 | + | 180 | WP_081018751.1 | DUF645 family protein | - |
| GPX95_RS18085 | 1074102..1074830 | + | 729 | WP_148552986.1 | hypothetical protein | - |
| GPX95_RS18095 | 1075006..1075338 | - | 333 | WP_055032213.1 | SEC-C domain-containing protein | - |
| GPX95_RS18100 | 1075643..1076557 | + | 915 | WP_055032212.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 1024742..1129239 | 104497 | |
| - | inside | Integron | - | - | 1025906..1128911 | 103005 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11003.69 Da Isoelectric Point: 5.1098
>T144994 WP_015296903.1 NZ_CP046818:1071472-1071759 [Vibrio metoecus]
MKVVWSPLALQKLGDAAEFISLDNPPAAEKWVNEVFDKTELLGSMPEMGRFVPEMPHTNYREIIFGHYRIIYSLSHEIRV
LTVRNCRQILSEDDV
MKVVWSPLALQKLGDAAEFISLDNPPAAEKWVNEVFDKTELLGSMPEMGRFVPEMPHTNYREIIFGHYRIIYSLSHEIRV
LTVRNCRQILSEDDV
Download Length: 288 bp
>T144994 NZ_CP062249:c242726-242448 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA
Antitoxin
Download Length: 94 a.a. Molecular weight: 10398.91 Da Isoelectric Point: 5.8650
>AT144994 WP_000086647.1 NZ_CP046818:1071194-1071475 [Vibrio metoecus]
MSRIHFDQDIQPLSEFRAGVASYIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLASGLGVSN
DDARAQVLGRIKK
MSRIHFDQDIQPLSEFRAGVASYIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLASGLGVSN
DDARAQVLGRIKK
Download Length: 282 bp
>AT144994 NZ_CP062249:c242989-242729 [Escherichia coli]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCAGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCATTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCAGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCATTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0H2MSY5 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A4P8G0X0 |