Detailed information of TA system TA144993

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-YefM
• Location: 1067526..1068071
• Replicon: chromosome
• Accession: NZ_CP046818
• Organism: Vibrio metoecus strain 06-2478

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: GPX95_RS18015
• Protein ID: WP_055032189.1
• Coordinates: 1067526..1067822 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: D0III5
• Locus tag: GPX95_RS18020
• Protein ID: WP_000557295.1
• Coordinates: 1067829..1068071 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GPX95_RS17980	1063714..1064379	+	666	WP_158160343.1	hypothetical protein	-
GPX95_RS17990	1064674..1064853	+	180	WP_158160344.1	DUF645 family protein	-
GPX95_RS17995	1065051..1066034	+	984	WP_055032191.1	hypothetical protein	-
GPX95_RS18000	1066031..1066150	+	120	Protein_928	DUF3265 domain-containing protein	-
GPX95_RS18005	1066336..1066518	+	183	WP_055032196.1	DUF645 family protein	-
GPX95_RS18010	1066698..1067339	+	642	WP_055032190.1	hypothetical protein	-
GPX95_RS18015	1067526..1067822	-	297	WP_055032189.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GPX95_RS18020	1067829..1068071	-	243	WP_000557295.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
GPX95_RS18025	1068373..1068762	+	390	WP_199250741.1	VOC family protein	-
GPX95_RS18725	1068833..1068952	+	120	WP_198926210.1	acetyltransferase	-
GPX95_RS18030	1068929..1069438	-	510	WP_055032250.1	hypothetical protein	-
GPX95_RS18040	1069716..1069952	-	237	WP_000772130.1	RNA-binding protein	-
GPX95_RS18045	1070204..1070995	+	792	WP_158160346.1	hypothetical protein	-
GPX95_RS18050	1071194..1071475	+	282	WP_000086647.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
GPX95_RS18055	1071472..1071759	+	288	WP_015296903.1	type II toxin-antitoxin system RelE/ParE family toxin	-
GPX95_RS18730	1071787..1071879	+	93	WP_079767280.1	DUF3265 domain-containing protein	-
GPX95_RS18060	1071906..1072823	+	918	WP_055032217.1	hypothetical protein	-
GPX95_RS18065	1072817..1072930	+	114	Protein_942	DUF3265 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1024742..1129239	104497
	-	inside	Integron	-	-	1025906..1128911	103005

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-93)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-61)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11292.96 Da
• Isoelectric Point: 9.6269

>T144993 WP_055032189.1 NZ_CP046818:c1067822-1067526 [Vibrio metoecus]
MQKNKYKLSKLAQTHLQKIKNYTVNNFSEMQWRSYKDTLLTGFQMLAENPAVGRSCDEIYPSGFYFPVGKHTAYFTKEDG
FILVVAVLGQSQLPQNHL

Nucleotide

• Length: 297 bp

>T144993 NZ_CP062248:c4569658-4569317 [Escherichia coli]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCATGTCACCGTCGGTTA
TGCGAGTCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CTGGCACGGCGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGAGGAGAGCGAA
CTGATGCAGTCGCTACGCCAGGTGTGCAAACTGTCGGCGCGTAAACAAAAGCAGGTGCAGGCGTTTATTGGAGTGATTGC
CGGTAAACAGAAAGTCGCGTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9002.17 Da
• Isoelectric Point: 4.7914

>AT144993 WP_000557295.1 NZ_CP046818:c1068071-1067829 [Vibrio metoecus]
MHTLTANDAKRNFGELLLSAQREPVKISKNSKDAVVVMSIKDYEELEAMKTDYLRHCFESAKQDLAQGNVVDGEDFLNAL

Nucleotide

• Length: 243 bp

>AT144993 NZ_CP062248:4569653-4569729 [Escherichia coli]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Antitoxin

• AlphaFold DB: A0A151KU25